A pH-driven ring translocation switch against cancer cells

2018 ◽  
Vol 54 (98) ◽  
pp. 13825-13828 ◽  
Author(s):  
Qian Cheng ◽  
Hang Yin ◽  
Roselyne Rosas ◽  
Didier Gigmes ◽  
Olivier Ouari ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Fatigue Resistance ◽  
Molecular Switch ◽  
High Fatigue ◽  
Imidazole Compound

A molecular switch built with cucurbit[7]uril and a 3-station viologen-phenylene-imidazole compound has showed pH actuated ring translocation with high fatigue resistance and promising features against cancer cells.

scholarly journals Effect of mesoscale phase contrast on fatigue-delaying behavior of self-healing hydrogels

2021 ◽  
Vol 7 (16) ◽  
pp. eabe8210
Author(s):  
Xueyu Li ◽  
Kunpeng Cui ◽  
Takayuki Kurokawa ◽  
Ya Nan Ye ◽  
Tao Lin Sun ◽  
...  
Keyword(s):  
Crack Growth ◽  
Fatigue Resistance ◽  
Phase Contrast ◽  
Stress Singularity ◽  
Soft Materials ◽  
Self Healing ◽  
Strong Phase ◽  
Mesoscale Structure ◽  
High Fatigue ◽  
Affine Deformation

We investigate the fatigue resistance of chemically cross-linked polyampholyte hydrogels with a hierarchical structure due to phase separation and find that the details of the structure, as characterized by SAXS, control the mechanisms of crack propagation. When gels exhibit a strong phase contrast and a low cross-linking level, the stress singularity around the crack tip is gradually eliminated with increasing fatigue cycles and this suppresses crack growth, beneficial for high fatigue resistance. On the contrary, the stress concentration persists in weakly phase-separated gels, resulting in low fatigue resistance. A material parameter, λtran, is identified, correlated to the onset of non-affine deformation of the mesophase structure in a hydrogel without crack, which governs the slow-to-fast transition in fatigue crack growth. The detailed role played by the mesoscale structure on fatigue resistance provides design principles for developing self-healing, tough, and fatigue-resistant soft materials.

Multi-Arch-Structured All-Carbon Aerogels with Superelasticity and High Fatigue Resistance as Wearable Sensors

2020 ◽  
Vol 12 (14) ◽  
pp. 16822-16830 ◽  
Author(s):  
Jiankun Huang ◽  
Jingbin Zeng ◽  
Baoqiang Liang ◽  
Junwei Wu ◽  
Tongge Li ◽  
...  
Keyword(s):  
Fatigue Resistance ◽  
Wearable Sensors ◽  
Carbon Aerogels ◽  
High Fatigue

scholarly journals Muscle-like fatigue-resistant hydrogels by mechanical training

2019 ◽  
Vol 116 (21) ◽  
pp. 10244-10249 ◽  
Author(s):  
Shaoting Lin ◽  
Ji Liu ◽  
Xinyue Liu ◽  
Xuanhe Zhao
Keyword(s):  
Fatigue Resistance ◽  
Skeletal Muscles ◽  
Amorphous Polymer ◽  
High Strength ◽  
High Water ◽  
Polymer Chains ◽  
High Water Content ◽  
High Fatigue ◽  
Synthetic Hydrogels ◽  
Crack Pinning

Skeletal muscles possess the combinational properties of high fatigue resistance (1,000 J/m2), high strength (1 MPa), low Young’s modulus (100 kPa), and high water content (70 to 80 wt %), which have not been achieved in synthetic hydrogels. The muscle-like properties are highly desirable for hydrogels’ nascent applications in load-bearing artificial tissues and soft devices. Here, we propose a strategy of mechanical training to achieve the aligned nanofibrillar architectures of skeletal muscles in synthetic hydrogels, resulting in the combinational muscle-like properties. These properties are obtained through the training-induced alignment of nanofibrils, without additional chemical modifications or additives. In situ confocal microscopy of the hydrogels’ fracturing processes reveals that the fatigue resistance results from the crack pinning by the aligned nanofibrils, which require much higher energy to fracture than the corresponding amorphous polymer chains. This strategy is particularly applicable for 3D-printed microstructures of hydrogels, in which we can achieve isotropically fatigue-resistant, strong yet compliant properties.

FEDERATED No. 15

Alloy Digest ◽  
1958 ◽  
Vol 7 (7) ◽  
Keyword(s):  
Fracture Toughness ◽  
Compressive Strength ◽  
Physical Properties ◽  
Tensile Properties ◽  
Fatigue Resistance ◽  
Base Alloy ◽  
Good Service ◽  
High Fatigue

Abstract Federated No. 15 is a lead-base alloy having high fatigue resistance. It is recommended for good service in precision bearings. This datasheet provides information on composition, physical properties, hardness, tensile properties, and compressive strength as well as fracture toughness and fatigue. It also includes information on casting and joining. Filing Code: Pb-5. Producer or source: Federated Metals Corporation, ASARCO Inc..

Nm23-H1 gene as a molecular switch between the free-floating and adherent states of gastric cancer cells

2001 ◽  
Vol 174 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Norio Iizuka ◽  
Akira Tangoku ◽  
Shoichi Hazama ◽  
Shigefumi Yoshino ◽  
Naohide Mori ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Molecular Switch ◽  
Gastric Cancer Cells
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