Selenols: a new class of carbonic anhydrase inhibitors

2019 ◽  
Vol 55 (5) ◽  
pp. 648-651 ◽  
Author(s):  
Andrea Angeli ◽  
Damiano Tanini ◽  
Alessio Nocentini ◽  
Antonella Capperucci ◽  
Marta Ferraroni ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Carbonic Anhydrase Inhibitors ◽  
New Class

Aryl selenols effectively inhibit carbonic anhydrase.

scholarly journals Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations

2012 ◽  
Vol 48 (13) ◽  
pp. 1868 ◽  
Author(s):  
Fabrizio Carta ◽  
Mayank Aggarwal ◽  
Alfonso Maresca ◽  
Andrea Scozzafava ◽  
Robert McKenna ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Carbonic Anhydrase Inhibitors ◽  
New Class ◽  
Kinetic Investigations

scholarly journals Catechols: a new class of carbonic anhydrase inhibitors

2020 ◽  
Vol 56 (85) ◽  
pp. 13033-13036 ◽  
Author(s):  
Katia D'Ambrosio ◽  
Simone Carradori ◽  
Stefania Cesa ◽  
Andrea Angeli ◽  
Simona M. Monti ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Water Molecule ◽  
Deep Water ◽  
Active Site ◽  
Bound Water ◽  
Binding Mode ◽  
Carbonic Anhydrase Inhibitors ◽  
New Class

Catechols adopt a peculiar binding mode to the CA active site which involves both the zinc bound water molecule and the “deep water”.

scholarly journals 3H-1,2-benzoxathiepine 2,2-dioxides: a new class of isoform-selective carbonic anhydrase inhibitors

2017 ◽  
Vol 32 (1) ◽  
pp. 767-775 ◽  
Author(s):  
Aleksandrs Pustenko ◽  
Dmitrijs Stepanovs ◽  
Raivis Žalubovskis ◽  
Daniela Vullo ◽  
Andris Kazaks ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Carbonic Anhydrase Inhibitors ◽  
New Class

Carbohydrazones as new class of carbonic anhydrase inhibitors: Synthesis, kinetics, and ligand docking studies

2017 ◽  
Vol 72 ◽  
pp. 89-101 ◽  
Author(s):  
Sarosh Iqbal ◽  
Muhammad Saleem ◽  
M. Kamran Azim ◽  
Muhammad Taha ◽  
Uzma Salar ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Docking Studies ◽  
Ligand Docking ◽  
Carbonic Anhydrase Inhibitors ◽  
New Class

Novel metronidazole-sulfonamide derivatives as potent and selective carbonic anhydrase inhibitors: design, synthesis and biology analysis

RSC Advances ◽  
2014 ◽  
Vol 4 (62) ◽  
pp. 33029-33038 ◽  
Author(s):  
Zhong-Chang Wang ◽  
Yong-Tao Duan ◽  
Han-Yue Qiu ◽  
Wan-Yun Huang ◽  
Peng-Fei Wang ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Enzymatic Activity ◽  
Carbonic Anhydrase Inhibitors ◽  
Design Synthesis ◽  
New Class ◽  
Human Carbonic Anhydrase

Metronidazole–sulfonamide derivatives, a new class of human carbonic anhydrase inhibitors (hCA), were designed, synthesized, isolated, and evaluated for their ability to inhibit the enzymatic activity of the isozymes hCA II and hCA IX.

scholarly journals Carbonic Anhydrase Inhibitors. Part 541: Metal Complexes of Heterocyclic Sulfonamides: A New Class of Antiglaucoma Agents

1997 ◽  
Vol 4 (6) ◽  
pp. 307-315 ◽  
Author(s):  
Claudiu T. Supuran ◽  
Andrea Scozzafava ◽  
Andrei Jitianu
Keyword(s):  
Intraocular Pressure ◽  
Carbonic Anhydrase ◽  
Metal Ions ◽  
Metal Complexes ◽  
Carbonic Anhydrase Inhibitors ◽  
Experimental Animals ◽  
New Class ◽  
Physico Chemical ◽  
Main Group Metal ◽  
Antiglaucoma Agents

Metal complexes of heterocyclic sulfonamides possessing carbonic anhydrase (CA) inhibitory properties were recently shown to be useful as intraocular pressure (IOP) lowering agents in experimental animals, and might be developed as a novel class of antiglaucoma drugs. Here we report the synthesis of a heterocyclic sulfonamide CA inhibitor and of the metal complexes containing main group metal ions, such as Be(II), Mg(II), Al(III), Zn(II), Cd(II) and Hg(II) and the new sulfonamide as well as 5-amino-1,3,4-thiadiazole-2-sulfonamide as ligands. The new complexes were characterized by standard physico-chemical procedures, and assayed as inhibitors of three CA isozymes, CA I, II and IV. Some of them (but not the parent sulfonamides) strongly lowered IOP in rabbits when administered as a 2% solution into the eye.

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