Novel metronidazole-sulfonamide derivatives as potent and selective carbonic anhydrase inhibitors: design, synthesis and biology analysis

RSC Advances ◽  
2014 ◽  
Vol 4 (62) ◽  
pp. 33029-33038 ◽  
Author(s):  
Zhong-Chang Wang ◽  
Yong-Tao Duan ◽  
Han-Yue Qiu ◽  
Wan-Yun Huang ◽  
Peng-Fei Wang ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Enzymatic Activity ◽  
Carbonic Anhydrase Inhibitors ◽  
Design Synthesis ◽  
New Class ◽  
Human Carbonic Anhydrase

Metronidazole–sulfonamide derivatives, a new class of human carbonic anhydrase inhibitors (hCA), were designed, synthesized, isolated, and evaluated for their ability to inhibit the enzymatic activity of the isozymes hCA II and hCA IX.

In-Silico Analysis of Chromone Containing Sulfonamide Derivatives as Human Carbonic Anhydrase Inhibitors

2013 ◽  
Vol 9 (4) ◽  
pp. 608-616 ◽  
Author(s):  
Zaheer Ul-Haq ◽  
Saman Usmani ◽  
Uzma Mahmood ◽  
Mariya al-Rashida ◽  
Ghulam Abbas
Keyword(s):  
Carbonic Anhydrase ◽  
In Silico ◽  
In Silico Analysis ◽  
Carbonic Anhydrase Inhibitors ◽  
Human Carbonic Anhydrase ◽  
Silico Analysis
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