Novel D–A–D based near-infrared probes for the detection of β-amyloid and Tau fibrils in Alzheimer's disease

2018 ◽  
Vol 54 (63) ◽  
pp. 8717-8720 ◽  
Author(s):  
Yuying Li ◽  
Kan Wang ◽  
Kaixiang Zhou ◽  
Wentao Guo ◽  
Bin Dai ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Near Infrared ◽  
Β Amyloid ◽  
Infrared Probes ◽  
Tau Fibrils

Novel D–π–A–π–D probes were investigated for the detection of Aβ plaques and NFTs.

N,O-Benzamide difluoroboron complexes as near-infrared probes for the detection of β-amyloid and tau fibrils

2020 ◽  
Vol 56 (53) ◽  
pp. 7269-7272
Author(s):  
Yimin Chen ◽  
Chang Yuan ◽  
Tianxin Xie ◽  
Yuying Li ◽  
Bin Dai ◽  
...  
Keyword(s):  
Near Infrared ◽  
Β Amyloid ◽  
Infrared Probes ◽  
Tau Fibrils

In this study, a series of organo difluoroboron probes with a BF2 benzamide moiety was designed, prepared and evaluated as Aβ and Tau probes.

A hemicyanine derivative for near-infrared imaging of β-amyloid plaques in Alzheimer's disease

2019 ◽  
Vol 179 ◽  
pp. 736-743 ◽  
Author(s):  
Hua-Li Yang ◽  
Si-Qiang Fang ◽  
Yan-Wei Tang ◽  
Cheng Wang ◽  
Heng Luo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Amyloid Plaques ◽  
Near Infrared Imaging ◽  
Β Amyloid

Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines As Imaging Agents for Tau Fibrils and β-Amyloid Plaques in Alzheimer’s Disease Models

2012 ◽  
Vol 55 (21) ◽  
pp. 9170-9180 ◽  
Author(s):  
Alexander Boländer ◽  
Daniel Kieser ◽  
Constantin Voss ◽  
Silvia Bauer ◽  
Christian Schön ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Plaques ◽  
Imaging Agents ◽  
Disease Models ◽  
Β Amyloid ◽  
Tau Fibrils

scholarly journals Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer’s disease mouse model

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Lechan Tao ◽  
Qi Liu ◽  
Fuli Zhang ◽  
Yuting Fu ◽  
Xi Zhu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Near Infrared ◽  
Biological Responses ◽  
Near Infrared Spectra ◽  
Amyloid Aβ ◽  
Β Amyloid ◽  
Aβ Clearance ◽  
Ad Mouse Model

AbstractPhotobiomodulation, by utilizing low-power light in the visible and near-infrared spectra to trigger biological responses in cells and tissues, has been considered as a possible therapeutic strategy for Alzheimer’s disease (AD), while its specific mechanisms have remained elusive. Here, we demonstrate that cognitive and memory impairment in an AD mouse model can be ameliorated by 1070-nm light via reducing cerebral β-amyloid (Aβ) burden, the hallmark of AD. The glial cells, including microglia and astrocytes, play important roles in Aβ clearance. Our results show that 1070-nm light pulsed at 10 Hz triggers microglia rather than astrocyte responses in AD mice. The 1070-nm light-induced microglia responses with alteration in morphology and increased colocalization with Aβ are sufficient to reduce Aβ load in AD mice. Moreover, 1070-nm light pulsed at 10 Hz can reduce perivascular microglia and promote angiogenesis to further enhance Aβ clearance. Our study confirms the important roles of microglia and cerebral vessels in the use of 1070-nm light for the treatment of AD mice and provides a framework for developing a novel therapeutic approach for AD.

A Smart Near-Infrared Fluorescence Probe for Selective Detection of Tau Fibrils in Alzheimer’s Disease

2016 ◽  
Vol 7 (11) ◽  
pp. 1474-1481 ◽  
Author(s):  
Yujin Seo ◽  
Kwang-su Park ◽  
Taewoong Ha ◽  
Mi Kyoung Kim ◽  
Yu Jin Hwang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Near Infrared ◽  
Fluorescence Probe ◽  
Selective Detection ◽  
Near Infrared Fluorescence ◽  
Tau Fibrils

A curcumin-based molecular probe for near-infrared fluorescence imaging of tau fibrils in Alzheimer's disease

2015 ◽  
Vol 13 (46) ◽  
pp. 11194-11199 ◽  
Author(s):  
Kwang-su Park ◽  
Yujin Seo ◽  
Mi Kyoung Kim ◽  
Kyungdo Kim ◽  
Yun Kyung Kim ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Diagnosis ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Molecular Probe ◽  
Near Infrared Fluorescence ◽  
Nir Fluorescence ◽  
Near Infrared Fluorescence Imaging ◽  
Tau Fibrils

In recent years, there has been growing interest in the near-infrared (NIR) fluorescence imaging of tau fibrils for the early diagnosis of Alzheimer's disease (AD).

Аnticholinesterase and antioxidant activity of new binary conjugates of (с)-carbolines

2019 ◽  
Vol 484 (1) ◽  
pp. 104-108
Author(s):  
G. F. Makhaeva ◽  
E. F. Shevtsova ◽  
N. P. Boltneva ◽  
N. V. Kovaleva ◽  
E. V. Rudakova ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Antioxidant Activity ◽  
Anticholinesterase Activity ◽  
Amyloid Aggregation ◽  
Varying Length ◽  
Β Amyloid ◽  
New Compounds

This study presents the synthesis of binary tetrohydro-γ-carbolines with ditriazol spacers of varying length, which exhibit anticholinesterase and antioxidant activity, as compared to the original Dimebon prototype. Anticholinesterase activity suggests the potential ability of the new compounds to block β-amyloid aggregation induced by anticholinesterase, making them promising candidates for further research preparations for the treatment of Alzheimer's disease. Particular attention should be paid to the conjugate with an intertriazol hexamethylene spacer, which can be regarded as the leading compound in this series.

Alzheimer’s Disease: Erythrocyte 2,3-diphosphoglycerate Content and Circulating Erythropoietin

2019 ◽  
Vol 16 (9) ◽  
pp. 834-835
Author(s):  
Petter Järemo ◽  
Alenka Jejcic ◽  
Vesna Jelic ◽  
Tasmin Shahnaz ◽  
Homira Behbahani ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Cell Damage ◽  
Control Group ◽  
Red Cell ◽  
Oxygen Release ◽  
Regulatory Pathways ◽  
Β Amyloid ◽  
2,3 Dpg

Background: Alzheimer’s Disease (AD) features the accumulation of β-amyloid in erythrocytes. The subsequent red cell damage may well affect their oxygen-carrying capabilities. 2,3- diphosphoglycerate (2,3-DPG) binds to the hemoglobin thereby promoting oxygen release. It is theorized that 2,3-DPG is reduced in AD and that the resulting hypoxia triggers erythropoietin (EPO) release. Methods & Objective: To explore this theory, we analyzed red cell 2,3-DPG content and EPO in AD, mild cognitive impairment, and the control group, subjective cognitive impairment. Results: We studied (i) 2,3-DPG in red cells, and (ii) circulating EPO in AD, and both markers were unaffected by dementia. Disturbances of these oxygen-regulatory pathways do not appear to participate in brain hypoxia in AD.

Synthesis of a Novel Curcumin Derivative as a Potential Imaging Probe in Alzheimer’s Disease Imaging

2019 ◽  
Vol 16 (8) ◽  
pp. 723-731 ◽  
Author(s):  
Alexander Sturzu ◽  
Sumbla Sheikh ◽  
Hubert Kalbacher ◽  
Thomas Nägele ◽  
Christopher Weidenmaier ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Flow Cytometry ◽  
Transgenic Mice ◽  
Ex Vivo ◽  
Amyloid Plaques ◽  
Laser Scanning Microscopy ◽  
Β Amyloid ◽  
Curcumin Derivative

Background: Curcumin has been of interest in the field of Alzheimer’s disease. Early studies on transgenic mice showed promising results in the reduction of amyloid plaques.However, curcumin is very poorly soluble in aqueous solutions and not easily accessible to coupling as it contains only phenolic groups as potential coupling sites. For these reasons only few imaging studies using curcumin bound as an ester were performed and curcumin is mainly used as nutritional supplement. Methods: In the present study we produced an aminoethyl ether derivative of curcumin using a nucleophilic substitution reaction. This is a small modification and should not impact the properties of curcumin while introducing an easily accessible reactive amino group. This novel compound could be used to couple curcumin to other molecules using the standard methods of peptide synthesis. We studied the aminoethyl-curcumin compound and a tripeptide carrying this aminoethyl-curcumin and the fluorescent dye fluorescein (FITC-curcumin) in vitro on cell culture using confocal laser scanning microscopy and flow cytometry. Then these two substances were tested ex vivo on brain sections prepared from transgenic mice depicting Alzheimer-like β-amyloid plaques. Results: In the in vitro CLSM microscopy and flow cytometry experiments we found dot-like unspecific uptake and only slight cytotoxicity correlating with this uptake. As these measurements were optimized for the use of fluorescein as dye we found that the curcumin at 488nm fluorescence excitation was not strong enough to use it as a fluorescence marker in these applications. In the ex vivo sections CLSM experiments both the aminoethyl-curcumin and the FITC-curcumin peptide bound specifically to β- amyloid plaques. Conclusion: In conclusion we successfully produced a novel curcumin derivative which could easily be coupled to other imaging or therapeutic molecules as a sensor for amyloid plaques.

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