A plausible model correlates prebiotic peptide synthesis with the primordial genetic code

2018 ◽  
Vol 54 (62) ◽  
pp. 8598-8601 ◽  
Author(s):  
Jianxi Ying ◽  
Songsen Fu ◽  
Xin Li ◽  
Liubin Feng ◽  
Pengxiang Xu ◽  
...  
Keyword(s):  
Genetic Code ◽  
Peptide Synthesis ◽  
Plausible Model ◽  
Primordial Genetic Code ◽  
Prebiotic Peptide Synthesis

The analogs of 5′-aa-AMPs, namely nucleotide amidates (aa-N-NMPs), obtained under Hadean conditions. B = base.

Coupled amino acid vestiges of the primordial genetic code

1984 ◽  
Vol 14 (1-4) ◽  
pp. 589-596 ◽  
Author(s):  
Daniel Grafstein
Keyword(s):  
Amino Acid ◽  
Genetic Code ◽  
Primordial Genetic Code

Trimetaphosphate and imidazole—Possible reagents in prebiotic peptide synthesis

2016 ◽  
Vol 191 (11-12) ◽  
pp. 1558-1559 ◽  
Author(s):  
Nikita Yu. Serov ◽  
Valery G. Shtyrlin ◽  
Khasan R. Khayarov
Keyword(s):  
Peptide Synthesis ◽  
Prebiotic Peptide Synthesis

Nonrandomness in prebiotic peptide synthesis

1990 ◽  
Vol 30 (5) ◽  
pp. 391-399 ◽  
Author(s):  
Sanjay Tyagi ◽  
Cyril Ponnamperuma
Keyword(s):  
Peptide Synthesis ◽  
Prebiotic Peptide Synthesis

Prebiotic Peptide Synthesis and Spontaneous Amyloid Formation Inside a Proto‐Cellular Compartment

2020 ◽  
Author(s):  
Witek Kwiatkowski ◽  
Radoslaw Bomba ◽  
Pavel Afanasyev ◽  
Daniel Boehringer ◽  
Roland Riek ◽  
...  
Keyword(s):  
Peptide Synthesis ◽  
Amyloid Formation ◽  
Cellular Compartment ◽  
Prebiotic Peptide Synthesis

scholarly journals The ATP Hypothesis: A New Conceptual Framework for the Origin of the Genetic Code

2020 ◽  
Author(s):  
Ping Xie
Keyword(s):  
Genetic Code ◽  
Building Blocks ◽  
Photochemical Reactions ◽  
Darwinian Evolution ◽  
Biochemical System ◽  
Genetic Codes ◽  
Cellular Life ◽  
Biochemical Systems ◽  
Primordial Genetic Code ◽  
New Hypothesis

A plenty of theories on the origin of genetic codes have been proposed so far, yet all ignored its energetic relation to the biochemical system. Here, a new hypothesis is proposed, according to which ATP is at the origin of the primordial genetic code by its coevolution with the pristine biochemical system. This hypothesis aims to show how the genetic code was produced by photochemical reactions in a protocell that derived from a lipid vescile enclosing various life’s building blocks (e.g. nucleotides and peptides). At extant cell, ATP is the only energetic product of photosynthesis, and is at the energetic heart of the biochemical systems. ATP could energetically elongate chains of both polynucleotides and polypeptides, thus providing a bridge between these bio-polymers and eventually mediating cellular biochemical innovation from energy transformation to informatization. ATP was not the only one that could drive the formation of polynucleotides and polypeptides, but favored by precellular selection. The protocell innovated a photosynthesis system to produce ATP efficiently and regularly with the aids of proteins and RNA/DNA. The completion of the genetic code from RNA to DNA marked the dawn of cellular life operated by Darwinian evolution. The ATP hypothesis supports the photochemical origin of life, shedding light on the formation of both photosynthetic and biochemical systems, which remains largely unknown thus far.

scholarly journals The ATP Hypothesis: A New Conceptual Framework for the Origin of the Genetic Code

2020 ◽  
Author(s):  
Ping Xie
Keyword(s):  
Genetic Code ◽  
Building Blocks ◽  
Photochemical Reactions ◽  
Darwinian Evolution ◽  
Biochemical System ◽  
Genetic Codes ◽  
Cellular Life ◽  
Biochemical Systems ◽  
Primordial Genetic Code ◽  
New Hypothesis

A plenty of theories on the origin of genetic codes have been proposed so far, yet all ignored its energetic relation to the biochemical system. Here, a new hypothesis is proposed, according to which ATP is at the origin of the primordial genetic code by its coevolution with the pristine biochemical system. This hypothesis aims to show how the genetic code was produced by photochemical reactions in a protocell that derived from a lipid vescile enclosing various life’s building blocks (e.g. nucleotides and peptides) . At extant cell, ATP is the only energetic product of photosynthesis, and is at the energetic heart of the biochemical systems. In the prelife vescile, ATP energetically elongated chains of both polynucleotides and polypeptides, thus providing a bridge between these molecules and eventually mediating biochemical innovation in the protocell from energy transformation to informatization. ATP was not the only one that could drive the formation of polynucleotides and polypeptides, but favored by precellular selection. The protocell innovated the photosynthesis system to produce ATP, which later has been processed efficiently and regularly with the aids of proteins and RNA/DNA. The completion of the genetic code from RNA to DNA marked the dawn of cellular life operated by Darwinian evolution. The ATP hypothesis supports the photochemical origin of life, shedding light on the formation of both photosynthetic and biochemical systems, which remains largely unknown thus far.

scholarly journals The ATP Hypothesis Discovers the Missing “Matchmaker” between Proteins and Nucleic Acids

2020 ◽  
Author(s):  
Ping Xie
Keyword(s):  
Nucleic Acids ◽  
Genetic Code ◽  
Building Blocks ◽  
Photochemical Reactions ◽  
Darwinian Evolution ◽  
Lipid Vesicle ◽  
Biochemical System ◽  
Genetic Codes ◽  
Biochemical Systems ◽  
Primordial Genetic Code

A plenty of theories on the origin of genetic codes have been proposed so far, yet all ignored the energetic driving force, its relation to the biochemical system, and most importantly, the missing “matchmaker” between proteins and nucleic acids. Here, a new hypothesis is proposed, according to which ATP is at the origin of the primordial genetic code by driving the coevolution of the genetic code with the pristine biochemical system. This hypothesis aims to show how the genetic code was produced by photochemical reactions in a protocell that derived from a lipid vesicle enclosing various life’s building blocks (e.g. nucleotides and peptides). At extant cell, ATP is the only energetic product of photosynthesis, and is at the energetic heart of the biochemical systems. ATP could energetically form and elongate chains of both polynucleotides and polypeptides, thus acting a “matchmaker” between these two bio-polymers and eventually mediating precellular biochemical innovation from energy transformation to informatization. ATP was not the only one that could drive the formation of polynucleotides and polypeptides, but favored by precellular selection. The protocell innovated a photosynthesis system to produce ATP efficiently and regularly with the aids of proteins and RNA/DNA. The completion of permanently recording the genetic information by DNA marked the dawn of cellular life operated by Darwinian evolution. The ATP hypothesis supports the photochemical origin of life, shedding light on the origins of both photosynthetic and biochemical systems, which remains largely unknown thus far.

Experimental bases for a primordial genetic code

1986 ◽  
Vol 16 (3-4) ◽  
pp. 535-536
Author(s):  
M. Angélica Soto ◽  
José Tohá ◽  
Ximena Cuadros
Keyword(s):  
Genetic Code ◽  
Primordial Genetic Code
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