Experimental bases for a primordial genetic code

1986 ◽  
Vol 16 (3-4) ◽  
pp. 535-536
Author(s):  
M. Angélica Soto ◽  
José Tohá ◽  
Ximena Cuadros
Keyword(s):  
Genetic Code ◽  
Primordial Genetic Code

A plausible model correlates prebiotic peptide synthesis with the primordial genetic code

2018 ◽  
Vol 54 (62) ◽  
pp. 8598-8601 ◽  
Author(s):  
Jianxi Ying ◽  
Songsen Fu ◽  
Xin Li ◽  
Liubin Feng ◽  
Pengxiang Xu ◽  
...  
Keyword(s):  
Genetic Code ◽  
Peptide Synthesis ◽  
Plausible Model ◽  
Primordial Genetic Code ◽  
Prebiotic Peptide Synthesis

The analogs of 5′-aa-AMPs, namely nucleotide amidates (aa-N-NMPs), obtained under Hadean conditions. B = base.

Coupled amino acid vestiges of the primordial genetic code

1984 ◽  
Vol 14 (1-4) ◽  
pp. 589-596 ◽  
Author(s):  
Daniel Grafstein
Keyword(s):  
Amino Acid ◽  
Genetic Code ◽  
Primordial Genetic Code

scholarly journals The ATP Hypothesis: A New Conceptual Framework for the Origin of the Genetic Code

2020 ◽  
Author(s):  
Ping Xie
Keyword(s):  
Genetic Code ◽  
Building Blocks ◽  
Photochemical Reactions ◽  
Darwinian Evolution ◽  
Biochemical System ◽  
Genetic Codes ◽  
Cellular Life ◽  
Biochemical Systems ◽  
Primordial Genetic Code ◽  
New Hypothesis

A plenty of theories on the origin of genetic codes have been proposed so far, yet all ignored its energetic relation to the biochemical system. Here, a new hypothesis is proposed, according to which ATP is at the origin of the primordial genetic code by its coevolution with the pristine biochemical system. This hypothesis aims to show how the genetic code was produced by photochemical reactions in a protocell that derived from a lipid vescile enclosing various life’s building blocks (e.g. nucleotides and peptides). At extant cell, ATP is the only energetic product of photosynthesis, and is at the energetic heart of the biochemical systems. ATP could energetically elongate chains of both polynucleotides and polypeptides, thus providing a bridge between these bio-polymers and eventually mediating cellular biochemical innovation from energy transformation to informatization. ATP was not the only one that could drive the formation of polynucleotides and polypeptides, but favored by precellular selection. The protocell innovated a photosynthesis system to produce ATP efficiently and regularly with the aids of proteins and RNA/DNA. The completion of the genetic code from RNA to DNA marked the dawn of cellular life operated by Darwinian evolution. The ATP hypothesis supports the photochemical origin of life, shedding light on the formation of both photosynthetic and biochemical systems, which remains largely unknown thus far.

scholarly journals The ATP Hypothesis: A New Conceptual Framework for the Origin of the Genetic Code

2020 ◽  
Author(s):  
Ping Xie
Keyword(s):  
Genetic Code ◽  
Building Blocks ◽  
Photochemical Reactions ◽  
Darwinian Evolution ◽  
Biochemical System ◽  
Genetic Codes ◽  
Cellular Life ◽  
Biochemical Systems ◽  
Primordial Genetic Code ◽  
New Hypothesis

A plenty of theories on the origin of genetic codes have been proposed so far, yet all ignored its energetic relation to the biochemical system. Here, a new hypothesis is proposed, according to which ATP is at the origin of the primordial genetic code by its coevolution with the pristine biochemical system. This hypothesis aims to show how the genetic code was produced by photochemical reactions in a protocell that derived from a lipid vescile enclosing various life’s building blocks (e.g. nucleotides and peptides) . At extant cell, ATP is the only energetic product of photosynthesis, and is at the energetic heart of the biochemical systems. In the prelife vescile, ATP energetically elongated chains of both polynucleotides and polypeptides, thus providing a bridge between these molecules and eventually mediating biochemical innovation in the protocell from energy transformation to informatization. ATP was not the only one that could drive the formation of polynucleotides and polypeptides, but favored by precellular selection. The protocell innovated the photosynthesis system to produce ATP, which later has been processed efficiently and regularly with the aids of proteins and RNA/DNA. The completion of the genetic code from RNA to DNA marked the dawn of cellular life operated by Darwinian evolution. The ATP hypothesis supports the photochemical origin of life, shedding light on the formation of both photosynthetic and biochemical systems, which remains largely unknown thus far.

scholarly journals The ATP Hypothesis Discovers the Missing “Matchmaker” between Proteins and Nucleic Acids

2020 ◽  
Author(s):  
Ping Xie
Keyword(s):  
Nucleic Acids ◽  
Genetic Code ◽  
Building Blocks ◽  
Photochemical Reactions ◽  
Darwinian Evolution ◽  
Lipid Vesicle ◽  
Biochemical System ◽  
Genetic Codes ◽  
Biochemical Systems ◽  
Primordial Genetic Code

A plenty of theories on the origin of genetic codes have been proposed so far, yet all ignored the energetic driving force, its relation to the biochemical system, and most importantly, the missing “matchmaker” between proteins and nucleic acids. Here, a new hypothesis is proposed, according to which ATP is at the origin of the primordial genetic code by driving the coevolution of the genetic code with the pristine biochemical system. This hypothesis aims to show how the genetic code was produced by photochemical reactions in a protocell that derived from a lipid vesicle enclosing various life’s building blocks (e.g. nucleotides and peptides). At extant cell, ATP is the only energetic product of photosynthesis, and is at the energetic heart of the biochemical systems. ATP could energetically form and elongate chains of both polynucleotides and polypeptides, thus acting a “matchmaker” between these two bio-polymers and eventually mediating precellular biochemical innovation from energy transformation to informatization. ATP was not the only one that could drive the formation of polynucleotides and polypeptides, but favored by precellular selection. The protocell innovated a photosynthesis system to produce ATP efficiently and regularly with the aids of proteins and RNA/DNA. The completion of permanently recording the genetic information by DNA marked the dawn of cellular life operated by Darwinian evolution. The ATP hypothesis supports the photochemical origin of life, shedding light on the origins of both photosynthetic and biochemical systems, which remains largely unknown thus far.

scholarly journals The ATP hypothesis discovers the missing “matchmaker” between proteins and nucleic acids

2020 ◽  
Author(s):  
Ping Xie
Keyword(s):  
Nucleic Acids ◽  
Genetic Code ◽  
Building Blocks ◽  
Photochemical Reactions ◽  
Darwinian Evolution ◽  
Lipid Vesicle ◽  
Biochemical System ◽  
Genetic Codes ◽  
Biochemical Systems ◽  
Primordial Genetic Code

A plenty of theories on the origin of genetic codes have been proposed so far, yet all ignored the energetic driving force, its relation to the biochemical system, and most importantly, the missing “matchmaker” between proteins and nucleic acids. Here, a new hypothesis is proposed, according to which ATP is at the origin of the primordial genetic code by driving the coevolution of the genetic code with the pristine biochemical system. This hypothesis aims to show how the genetic code was produced by photochemical reactions in a protocell that derived from a lipid vesicle enclosing various life’s building blocks (e.g. nucleotides and peptides). At extant cell, ATP is the only energetic product of photosynthesis, and is at the energetic heart of the biochemical systems. ATP could energetically form and elongate chains of both polynucleotides and polypeptides, thus acting a “matchmaker” between these two bio-polymers and eventually mediating precellular biochemical innovation from energy transformation to informatization. ATP was not the only one that could drive the formation of polynucleotides and polypeptides, but favored by precellular selection. The protocell innovated a photosynthesis system to produce ATP efficiently and regularly with the aids of proteins and RNA/DNA. The completion of permanently recording the genetic information by DNA marked the dawn of cellular life operated by Darwinian evolution. The ATP hypothesis supports the photochemical origin of life, shedding light on the origins of both photosynthetic and biochemical systems, which remains largely unknown thus far.

Ideology and Science (based on the discussion in CEMI RAS)

2019 ◽  
pp. 55-68
Author(s):  
V.L. Makarov ◽  
V.G. Grebennikov ◽  
V.E. Dementyev ◽  
E.V. Ustyuzhanina
Keyword(s):  
Genetic Code ◽  
Mathematical Institute ◽  
Tea Party ◽  
Russian Academy Of Sciences ◽  
Academy Of Sciences ◽  
Central Economic

The debating society “Makarov’s tea party” chaired by the academician V.L. Makarov met on the 18th April 2019 in the Central Economic Mathematical Institute of the Russian Academy of Sciences in order to discuss the interrelationship between ideology and science. The society raised such issues as opposition and interpenetration of science and ideology; ideology and the genetic code of a nation; ideology and manipulation of conscience; numbers and facts as tools of ideological intervention. Here we present the most interesting points of the discussion. The authors of the reports: Makarov Valery, Doctor of Phys.-math., member of the Russian Academy of Sciences; Dementiev Victor, Doctor of Economics, Corr. RAS; Grebennikov Valery, Doctor of Economics; Ustyuzhanina Elena, Doctor of Economics.

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