The influence of trapping agents on the antitumor efficacy of irinotecan liposomes: head-to-head comparison of ammonium sulfate, sulfobutylether-β-cyclodextrin and sucrose octasulfate

2019 ◽  
Vol 7 (1) ◽  
pp. 419-428 ◽  
Author(s):  
Wenqian Yang ◽  
Zimeng Yang ◽  
Jingru Fu ◽  
Mengran Guo ◽  
Bingjun Sun ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ammonium Sulfate ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Antitumor Efficacy ◽  
Outstanding Achievement ◽  
Sucrose Octasulfate ◽  
Remote Loading

Remote loading technology is an outstanding achievement in liposome-based drug delivery systems.

Size-dependent biodistribution and antitumor efficacy of polymer micelle drug delivery systems

2013 ◽  
Vol 1 (34) ◽  
pp. 4273 ◽  
Author(s):  
Jun Yue ◽  
Shi Liu ◽  
Zhigang Xie ◽  
Ying Xing ◽  
Xiabin Jing
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Antitumor Efficacy ◽  
Polymer Micelle ◽  
Size Dependent

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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