pH-Sensitive micelles with mitochondria-targeted and aggregation-induced emission characterization: synthesis, cytotoxicity and biological applications

2018 ◽  
Vol 6 (11) ◽  
pp. 2998-3008 ◽  
Author(s):  
Jieming Li ◽  
Yan Liu ◽  
Huilan Li ◽  
Wei Shi ◽  
Xinzhou Bi ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Tumor Targeting ◽  
Ph Sensitive ◽  
Biological Applications ◽  
Aggregation Induced Emission ◽  
Subcellular Organelle

Subcellular organelle-specific reagents for simultaneous tumor targeting, imaging, and treatment are of enormous interest in cancer therapy.

scholarly journals Spermine modified polymeric micelles with pH-sensitive drug release for targeted and enhanced antitumor therapy

RSC Advances ◽  
2019 ◽  
Vol 9 (20) ◽  
pp. 11026-11037 ◽  
Author(s):  
Yang Chen ◽  
Cejun Yang ◽  
Juan Mao ◽  
Haigang Li ◽  
Jinsong Ding ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Tumor Targeting ◽  
Polymeric Micelles ◽  
Ph Sensitive ◽  
Antitumor Therapy ◽  
Anti Cancer ◽  
Targeting Delivery

Tumor targeting delivery of SPM functionalized micelles via PTS binding and their endocytosis and pH-triggered endo/lysosome drug release for anti-cancer therapy.

scholarly journals Intra-mitochondrial reaction for cancer cell imaging and anti-cancer therapy by aggregation-induced emission

RSC Advances ◽  
2020 ◽  
Vol 10 (71) ◽  
pp. 43383-43388
Author(s):  
Sangpil Kim ◽  
Juhee Kim ◽  
Batakrishna Jana ◽  
Ja-Hyoung Ryu
Keyword(s):  
Cancer Therapy ◽  
Cancer Cell ◽  
Chemical Reactions ◽  
Cell Imaging ◽  
Cellular Function ◽  
Aggregation Induced Emission ◽  
Cancer Cell Imaging ◽  
Anti Cancer

Controlled intracellular chemical reactions to regulate cellular function remain a challenge in biology mimetic systems.

A Low Dose of Hydrous Icaritin Nano-Formulation with Remarkable Efficacy and Tumor Targeting in Cancer Therapy

2021 ◽  
Vol 17 (10) ◽  
pp. 2003-2013
Author(s):  
Jingxin Fu ◽  
Yian Wang ◽  
Haowen Li ◽  
Likang Lu ◽  
Hui Ao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Tumor Targeting ◽  
Low Dose ◽  
Drug Loading ◽  
Tumor Therapy ◽  
High Dose ◽  
Inhibition Rate ◽  
Tumor Inhibition ◽  
Nano Formulation ◽  
Tumor Inhibition Rate

Background: The use of chemotherapeutic drugs is restricted in the tumor-therapy because of the severely toxic and side effects among most important factors. The active herbal extracts are always used as a high dose while in the tumortherapy to achieve good anti-tumor effects. Hydrous icaritin has a high activity while there are few existing dosage forms as a result of low solubility in water and poor bioavailability. Results: The prepared hydrous icaritin nanorods (DP-HICT NRs) using mPEG2000-DSPE as a stabilizer, presented a narrow distribution of particle size with of 217 nm and a properly high drug-loading content of approximately 65.3±1.5%. A low dose of hydrous icaritin nano-formulation shows remarkable efficacy in cancer therapy (tumor inhibition rate: 61.36±10.80%) compared with the same dose of Paclitaxel injection (tumor inhibition rate: 66.80±4.43%), which approved as medicaments. Not only that, DP-HICT NRs can escape the clearance of the immune system and enhance targeting ability to the tumor site with only one excipient and such a low dose. Conclusions: This kind of nanoparticles contain a low dose of HICT used mPEG2000-DSPE as a stabilizer, while can achieve good tumor targeting as some active targeting agents and an anti-tumor effect as the PTX injection. There are broad prospects in drug safety, anti-tumor efficacy and even prognosis.

scholarly journals Tumor targeting of a cell penetrating peptide by fusing with a pH-sensitive histidine-glutamate co-oligopeptide

Biomaterials ◽  
2014 ◽  
Vol 35 (13) ◽  
pp. 4082-4087 ◽  
Author(s):  
Likun Fei ◽  
Li-Peng Yap ◽  
Peter S. Conti ◽  
Wei-Chiang Shen ◽  
Jennica L. Zaro
Keyword(s):  
Tumor Targeting ◽  
Ph Sensitive ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
A Cell
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