scholarly journals Self-healing, stretchable and robust interpenetrating network hydrogels

2018 ◽  
Vol 6 (11) ◽  
pp. 2932-2937 ◽  
Author(s):  
Laura J. Macdougall ◽  
Maria M. Pérez-Madrigal ◽  
Joshua E. Shaw ◽  
Maria Inam ◽  
Judith A. Hoyland ◽  
...  
Keyword(s):  
Cell Encapsulation ◽  
Self Healing ◽  
Network Approach ◽  
Natural Polymers ◽  
Interpenetrating Network ◽  
Hydrogel Network

A self-healable, mechanically strong and stretchable hydrogel network that supports cell encapsulation is reported to be achieved by creation of an interpenetrating network approach between PEG and natural polymers.

Hydrogel: Polymeric Smart Material in Drug Delivery

2016 ◽  
Vol 875 ◽  
pp. 45-62 ◽  
Author(s):  
Ranjana Das ◽  
Himadri Sekhar Samanta ◽  
Chiranjib Bhattacharjee
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Cell Encapsulation ◽  
Skin Grafting ◽  
Living System ◽  
Temperature Modulation ◽  
Self Healing ◽  
Natural Polymers ◽  
Ph Change

A ‘biomaterial’, recognizes some materials for biomedical applications like replacement of living system and wound stressing. ‘Biomaterials’ includes different compounds from diverse origins, like polymers, metals, ceramics and composites. Along with conventional natural polymers (polysaccharides, proteins), synthetic and biodegradable polymers like Polyvinyl alcohol, Polyvinylpyrrolidone, Polyetheleneglycol, Polylactic acid, Polyhydroxy acid are promisingly used in drug delivery, tissue engineering, biomedical sensing, skin grafting and medical adhesives. ‘Hydrogel’ a new generation biodegradable polymer typically used for pharmaceutical and medical purposes. Hydrogels are coined as super absorbent with significant function in health care, especially in wound treatment and protection. Unique characteristics features like enhanced hydrophilicity, biocompatibility, zero-toxicity and biodegradability along with soft and rubbery consistency, low interfacial tension and ‘self-healing’ properties make them compatible with living tissues. Hydrogels have been widely investigated as the carrier for drug delivery systems owing to their unusual characteristics like swelling in aqueous medium, pH and temperature sensitivity, or sensitivity towards other stimuli. Hydrogels being biocompatible materials have been recognized to function as drug protectors, especially for peptides and proteins, from in-vivo environment. In present context, development of ‘in situ’ forming systems for various biomedical applications, including drug delivery, cell encapsulation, and tissue repair are emerging. Among several typical hydrogel synthesis approaches like, solvent exchange, UV-irradiation, ionic cross-linkage, pH change, and temperature modulation, the ‘thermosensitive’ approach is advantageous since it does not require use of any organic solvents, co-polymerization agents and externally applied trigger for gelation. This review presents an overview to the advances in hydrogel based drug delivery system with some reconstructive features in the biomedical applications.

scholarly journals Irreversible and Self-Healing Electrically Conductive Hydrogels Made of Bio-Based Polymers

2022 ◽  
Vol 23 (2) ◽  
pp. 842
Author(s):  
Ahmed Ali Nada ◽  
Anita Eckstein Andicsová ◽  
Jaroslav Mosnáček
Keyword(s):  
Renewable Resources ◽  
Mechanical Stability ◽  
Conductive Polymers ◽  
Special Focus ◽  
Self Healing ◽  
Natural Polymers ◽  
Electrically Conductive ◽  
Preparation Methods ◽  
Cross Links ◽  
Conductive Hydrogels

Electrically conductive materials that are fabricated based on natural polymers have seen significant interest in numerous applications, especially when advanced properties such as self-healing are introduced. In this article review, the hydrogels that are based on natural polymers containing electrically conductive medium were covered, while both irreversible and reversible cross-links are presented. Among the conductive media, a special focus was put on conductive polymers, such as polyaniline, polypyrrole, polyacetylene, and polythiophenes, which can be potentially synthesized from renewable resources. Preparation methods of the conductive irreversible hydrogels that are based on these conductive polymers were reported observing their electrical conductivity values by Siemens per centimeter (S/cm). Additionally, the self-healing systems that were already applied or applicable in electrically conductive hydrogels that are based on natural polymers were presented and classified based on non-covalent or covalent cross-links. The real-time healing, mechanical stability, and electrically conductive values were highlighted.

scholarly journals Dynamic Mussel-Inspired Chitin Nanocomposite Hydrogels for Wearable Strain Sensors

Polymers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1416 ◽  
Author(s):  
Pejman Heidarian ◽  
Abbas Z. Kouzani ◽  
Akif Kaynak ◽  
Ali Zolfagharian ◽  
Hossein Yousefi
Keyword(s):  
Mechanical Properties ◽  
Polyacrylic Acid ◽  
Strain Sensors ◽  
Self Healing ◽  
Network Stability ◽  
Ferric Ions ◽  
Trade Off ◽  
Nanocomposite Hydrogels ◽  
Healing Efficiency ◽  
Hydrogel Network

It is an ongoing challenge to fabricate an electroconductive and tough hydrogel with autonomous self-healing and self-recovery (SELF) for wearable strain sensors. Current electroconductive hydrogels often show a trade-off between static crosslinks for mechanical strength and dynamic crosslinks for SELF properties. In this work, a facile procedure was developed to synthesize a dynamic electroconductive hydrogel with excellent SELF and mechanical properties from starch/polyacrylic acid (St/PAA) by simply loading ferric ions (Fe3+) and tannic acid-coated chitin nanofibers (TA-ChNFs) into the hydrogel network. Based on our findings, the highest toughness was observed for the 1 wt.% TA-ChNF-reinforced hydrogel (1.43 MJ/m3), which is 10.5-fold higher than the unreinforced counterpart. Moreover, the 1 wt.% TA-ChNF-reinforced hydrogel showed the highest resistance against crack propagation and a 96.5% healing efficiency after 40 min. Therefore, it was chosen as the optimized hydrogel to pursue the remaining experiments. Due to its unique SELF performance, network stability, superior mechanical, and self-adhesiveness properties, this hydrogel demonstrates potential for applications in self-wearable strain sensors.

scholarly journals Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

Polymers ◽  
2021 ◽  
Vol 13 (21) ◽  
pp. 3782
Author(s):  
Anupama Devi V. K. ◽  
Rohin Shyam ◽  
Arunkumar Palaniappan ◽  
Amit Kumar Jaiswal ◽  
Tae-Hwan Oh ◽  
...  
Keyword(s):  
Composite Materials ◽  
Biomedical Applications ◽  
Cell Encapsulation ◽  
Self Healing ◽  
3D Bioprinting ◽  
Engineering Systems ◽  
Future Perspectives ◽  
Non Covalent Interactions ◽  
Polymeric Hydrogels ◽  
Covalent Interactions

Polymeric hydrogels are widely explored materials for biomedical applications. However, they have inherent limitations like poor resistance to stimuli and low mechanical strength. This drawback of hydrogels gave rise to ‘’smart self-healing hydrogels’’ which autonomously repair themselves when ruptured or traumatized. It is superior in terms of durability and stability due to its capacity to reform its shape, injectability, and stretchability thereby regaining back the original mechanical property. This review focuses on various self-healing mechanisms (covalent and non-covalent interactions) of these hydrogels, methods used to evaluate their self-healing properties, and their applications in wound healing, drug delivery, cell encapsulation, and tissue engineering systems. Furthermore, composite materials are used to enhance the hydrogel’s mechanical properties. Hence, findings of research with various composite materials are briefly discussed in order to emphasize the healing capacity of such hydrogels. Additionally, various methods to evaluate the self-healing properties of hydrogels and their recent advancements towards 3D bioprinting are also reviewed. The review is concluded by proposing several pertinent challenges encountered at present as well as some prominent future perspectives.

Meniscal tissue engineering via 3D printed PLA monolith with carbohydrate based self-healing interpenetrating network hydrogel

2020 ◽  
Vol 162 ◽  
pp. 1358-1371 ◽  
Author(s):  
Santosh Gupta ◽  
Akriti Sharma ◽  
J. Vasantha Kumar ◽  
Vineeta Sharma ◽  
Piyush Kumar Gupta ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Self Healing ◽  
Interpenetrating Network ◽  
Meniscal Tissue ◽  
3D Printed

scholarly journals Transiently malleable multi-healable hydrogel nanocomposites based on responsive boronic acid copolymers

2018 ◽  
Vol 9 (4) ◽  
pp. 525-537 ◽  
Author(s):  
Adérito J. R. Amaral ◽  
Mina Emamzadeh ◽  
George Pasparakis
Keyword(s):  
Boronic Acid ◽  
Cell Encapsulation ◽  
Self Healing ◽  
Hydrogel Nanocomposites

Dynamic multi-responsive gel nanocomposites with rapid self-healing and cell encapsulation properties are presented.

Highly stretchable and tough alginate-based cyclodextrin/Azo-polyacrylamide interpenetrating network hydrogel with self-healing properties

2021 ◽  
Vol 256 ◽  
pp. 117595
Author(s):  
Furui He ◽  
Longzheng Wang ◽  
Shujuan Yang ◽  
Wenqi Qin ◽  
Yuhong Feng ◽  
...  
Keyword(s):  
Self Healing ◽  
Interpenetrating Network ◽  
Highly Stretchable

scholarly journals Research on synthesis and self-healing properties of interpenetrating network hydrogels based on reversible covalent and reversible non-covalent bonds

2021 ◽  
Vol 28 (1) ◽  
Author(s):  
Xiaowen Huang ◽  
Xiaofei Wang ◽  
Chuanying Shi ◽  
Yang Liu ◽  
Yanyan Wei
Keyword(s):  
Hydrogen Bonds ◽  
Disulfide Bonds ◽  
The Self ◽  
Self Healing ◽  
Complex Environment ◽  
Interpenetrating Network ◽  
Covalent Bonds ◽  
Healing Efficiency ◽  
Potential Applications ◽  
Reversible Covalent

AbstractFirst of all, we will provide a brief background on the self-healing hydrogels we produced which are suitable for the complex environment of nature. In this paper, disulfide bonds and acylhydrazone bonds can be combined in SH-WPU and hydrogen bonds existed in PAMAM. And the hydrogel can achieve self-healing under acid, alkaline, neutral or light environment.Self-healing for 1 h, 24 h and 48 h, the self-healing efficiency is 31.58%, 49.84% and 87.35% respectively. This effect achieved the desired effect and the repair effect is more obvious than previous research results. The hydrogels have potential applications in the field of biomaterials.

scholarly journals Biocompatible and Enzymatically Degradable Gels for 3D Cellular Encapsulation under Extreme Compressive Strain

Gels ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. 101
Author(s):  
Zain Clapacs ◽  
Sydney Neal ◽  
David Schuftan ◽  
Xiaohong Tan ◽  
Huanzhu Jiang ◽  
...  
Keyword(s):  
Cultured Cells ◽  
Compressive Strain ◽  
Cell Encapsulation ◽  
Strain Resistance ◽  
Interpenetrating Network ◽  
Future Studies ◽  
Encapsulated Cells ◽  
High Toughness ◽  
Cellular Mechanosensing

Cell encapsulating scaffolds are necessary for the study of cellular mechanosensing of cultured cells. However, conventional scaffolds used for loading cells in bulk generally fail at low compressive strain, while hydrogels designed for high toughness and strain resistance are generally unsuitable for cell encapsulation. Here we describe an alginate/gelatin methacryloyl interpenetrating network with multiple crosslinking modes that is robust to compressive strains greater than 70%, highly biocompatible, enzymatically degradable and able to effectively transfer strain to encapsulated cells. In future studies, this gel formula may allow researchers to probe cellular mechanosensing in bulk at levels of compressive strain previously difficult to investigate.

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