scholarly journals P-glycoprotein targeted photodynamic therapy of chemoresistant tumors using recombinant Fab fragment conjugates

2018 ◽  
Vol 6 (11) ◽  
pp. 3063-3074 ◽  
Author(s):  
Chengqiong Mao ◽  
Ping Qu ◽  
Michael J. Miley ◽  
Yan Zhao ◽  
Zibo Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Recombinant Antibody ◽  
Antibody Fragments ◽  
Fab Fragment ◽  
Specific Approach ◽  
P Glycoprotein ◽  
Recombinant Antibody Fragments ◽  
Targeted Photodynamic Therapy

The conjugates of recombinant antibody fragments were developed for Pgp-targeted PDT, providing a highly cancer-specific approach to combat chemoresistant tumors.

Targeted photodynamic therapy with multiply-loaded recombinant antibody fragments

2007 ◽  
Vol 122 (5) ◽  
pp. 1155-1163 ◽  
Author(s):  
Manpreet Bhatti ◽  
Gokhan Yahioglu ◽  
Lionel R. Milgrom ◽  
Mitla Garcia-Maya ◽  
Kerry A. Chester ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Recombinant Antibody ◽  
Antibody Fragments ◽  
Recombinant Antibody Fragments ◽  
Targeted Photodynamic Therapy

scholarly journals Use of nanogold- and fluorescent-labeled antibody Fv fragments in immunocytochemistry.

1996 ◽  
Vol 44 (3) ◽  
pp. 207-213 ◽  
Author(s):  
S Ribrioux ◽  
G Kleymann ◽  
W Haase ◽  
K Heitmann ◽  
C Ostermeier ◽  
...  
Keyword(s):  
Molecular Level ◽  
Paracoccus Denitrificans ◽  
Recombinant Antibody ◽  
Basic Research ◽  
Antibody Fragments ◽  
Halobacterium Halobium ◽  
Fab Fragment ◽  
Versatile Tool ◽  
One Step ◽  
Recombinant Antibody Fragments

Recombinant antibody fragments are emerging as a versatile tool in both basic research and medical therapy. We describe the procedures for direct labeling of engineered antibody fragments (Fv) with fluorescein or nanogold and their use in fluorescence and immunoelectron microscopy, respectively. The Fv fragments were produced in Escherichia coli, purified by one-step Strep tag affinity chromatography, chemically labeled with the marker, and employed in microscopy to localize epitopes on the membrane protein bacteriorhodopsin in purple membranes of Halobacterium halobium and the cytochrome c oxidase of Paracoccus denitrificans. In both cases, methods involving directly labeled antibody fragments show results identical to those in which antibodies or Fv fragments are detected by a secondarily labeled conjugate. The multifunctional design of the recombinant Fv fragments, however, offers more all-around applications in immunocytochemistry. The directly labeled Fv fragments, half the size of an Fab fragment, are at the molecular level the smallest antibody fragments yet described for visualization of biomolecules in microscopy.

The venom of the scorpion Centruroides limpidus, which causes the highest number of stings in Mexico, is neutralized by two recombinant antibody fragments

2021 ◽  
Vol 137 ◽  
pp. 247-255
Author(s):  
Guillermo Fernández-Taboada ◽  
Lidia Riaño-Umbarila ◽  
Alejandro Olvera-Rodríguez ◽  
Ilse Viridiana Gómez-Ramírez ◽  
Luis Fernando Losoya-Uribe ◽  
...  
Keyword(s):  
Recombinant Antibody ◽  
Antibody Fragments ◽  
Recombinant Antibody Fragments

Isolation and characterisation of Ebolavirus-specific recombinant antibody fragments from murine and shark immune libraries

2011 ◽  
Vol 48 (15-16) ◽  
pp. 2027-2037 ◽  
Author(s):  
Sarah A. Goodchild ◽  
Helen Dooley ◽  
Randal J. Schoepp ◽  
Martin Flajnik ◽  
Stephen G. Lonsdale
Keyword(s):  
Recombinant Antibody ◽  
Antibody Fragments ◽  
Recombinant Antibody Fragments

scholarly journals High-Affinity Recombinant Antibody Fragments (Fabs) Can Be Applied in Peptide Enrichment Immuno-MRM Assays

2014 ◽  
Vol 13 (4) ◽  
pp. 2187-2196 ◽  
Author(s):  
Jeffrey R. Whiteaker ◽  
Lei Zhao ◽  
Christian Frisch ◽  
Francisco Ylera ◽  
Stefan Harth ◽  
...  
Keyword(s):  
Recombinant Antibody ◽  
Antibody Fragments ◽  
High Affinity ◽  
Recombinant Antibody Fragments ◽  
Peptide Enrichment
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