scholarly journals Albumin as a “Trojan Horse” for polymeric nanoconjugate transendothelial transport across tumor vasculatures for improved cancer targeting

2018 ◽  
Vol 6 (5) ◽  
pp. 1189-1200 ◽  
Author(s):  
Qian Yin ◽  
Li Tang ◽  
Kaimin Cai ◽  
Xujuan Yang ◽  
Lichen Yin ◽  
...  
Keyword(s):  
Trojan Horse ◽  
Cancer Targeting ◽  
Transendothelial Transport ◽  
Target Cancer

An albumin-functionalized polymeric NC (Alb-NC) capable of crossing the endothelium barrier through a caveolaemediated transcytosis pathway to better target cancer is reported.

scholarly journals Targeting the “Sweet Side” of Tumor with Glycan-Binding Molecules Conjugated-Nanoparticles: Implications in Cancer Therapy and Diagnosis

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 289
Author(s):  
Nora Bloise ◽  
Mohammad Okkeh ◽  
Elisa Restivo ◽  
Cristina Della Pina ◽  
Livia Visai
Keyword(s):  
Cancer Diagnosis ◽  
Protein Glycosylation ◽  
Cancer Targeting ◽  
Cancer Tissue ◽  
Special Focus ◽  
Diagnosis And Therapy ◽  
Tumor Visualization ◽  
Therapy And Diagnosis ◽  
Cancer Diagnosis And Therapy ◽  
Target Cancer

Nanotechnology is in the spotlight of therapeutic innovation, with numerous advantages for tumor visualization and eradication. The end goal of the therapeutic use of nanoparticles, however, remains distant due to the limitations of nanoparticles to target cancer tissue. The functionalization of nanosystem surfaces with biological ligands is a major strategy for directing the actions of nanomaterials specifically to tumor cells. Cancer formation and metastasis are accompanied by profound alterations in protein glycosylation. Hence, the detection and targeting of aberrant glycans are of great value in cancer diagnosis and therapy. In this review, we provide a brief update on recent progress targeting aberrant glycosylation by functionalizing nanoparticles with glycan-binding molecules (with a special focus on lectins and anti-glycan antibodies) to improve the efficacy of nanoparticles in cancer targeting, diagnosis, and therapy and outline the challenges and limitations in implementing this approach. We envision that the combination of nanotechnological strategies and cancer-associated glycan targeting could remodel the field of cancer diagnosis and therapy, including immunotherapy.

Beware of ‘Trojan Horse Marketing’

2008 ◽  
Vol 39 (12) ◽  
pp. 14
Author(s):  
CHARLESE. CRUTCHFIELD
Keyword(s):  
Trojan Horse

HER2 overexpression and cancer targeting

2001 ◽  
Vol 28 (5N) ◽  
pp. 115-124 ◽  
Author(s):  
Shao-Chun Wang ◽  
Mien-Chie Hung
Keyword(s):  
Cancer Targeting ◽  
Her2 Overexpression

Modern Day Trojan Horse

2020 ◽  
Vol 5 (1) ◽  
pp. 33-37
Author(s):  
Zahra Sina ◽  
Nadia Abdullahi
Keyword(s):  
Young Adults ◽  
Life Cycle ◽  
Daily Basis ◽  
Correlation Study ◽  
Trojan Horse ◽  
Female Students ◽  
Personal Hygiene ◽  
The Public

Personal hygiene products are used on a daily basis by many people. Many are comparable to the Trojan horse. On the outside, they appear to be harmless. They are contained in attractive bottles and they rely on misleading ads to attract consumers. However, these products may contain potentially harmful chemicals and many people are unaware of how individuals, societies and environments are affected in the various stages of the life cycle of many personal hygiene products. Our STSE issue deals with an everyday product that falls under the Trojan horse analogy–lotion. We are concerned that our peers and other young adults are purchasing lotions without the knowledge of how they came to stand on the shelves of a store. We conducted a correlation study between gender and popular lotion brands among teenagers and the reasons behind their choices. We came to the conclusion that more females than males were interested in popular lotion brands due to enticing features that targets mainly feminine interests (e.g. scent is an aspect of lotion that more females than males consider when purchasing the brand). For our actions, we prepared an educational mind-map on our issue and a video compilation where we interviewed female students on their reactions to various lotion brand commercials. Our actions are meant to inform the public about the controversies surrounding our issue and the techniques companies use to gain the attention of potential consumers.

Big Theory: A Trojan Horse for Economics?

2015 ◽  
Vol 2 (1-2) ◽  
pp. 161-166 ◽  
Author(s):  
Michael W. Macy
Keyword(s):  
Trojan Horse

The Consequences of the Trojan Horse Affair and a Possible Way Forward for Birmingham

FORUM ◽  
2014 ◽  
Vol 56 (3) ◽  
pp. 457
Author(s):  
SARAH BARTON ◽  
RICHARD HATCHER
Keyword(s):  
Trojan Horse
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