Point-of-care monitoring of intracellular glutathione and serum triglyceride levels using a versatile personal glucose meter

2019 ◽  
Vol 11 (14) ◽  
pp. 1849-1856 ◽  
Author(s):  
Jinqiong Xu ◽  
Xiujuan Qiao ◽  
Jingjing Zhang ◽  
Ni Cheng ◽  
Qinglin Sheng ◽  
...  

Portable, cost-effective and quantitative detection of various targets related to health at home and in the field has the potential to revolutionize medical diagnostics.

2015 ◽  
Vol 10 (10) ◽  
pp. 2221-2227 ◽  
Author(s):  
Jingjing Zhang ◽  
Yu Xiang ◽  
Donna E. Novak ◽  
George E. Hoganson ◽  
Junjie Zhu ◽  
...  

2019 ◽  
Vol 55 (91) ◽  
pp. 13733-13736 ◽  
Author(s):  
Chunxue Liu ◽  
Yayun An ◽  
Yuanfu Zhang ◽  
Xia Li ◽  
Qingwang Xue ◽  
...  

Here, we developed a dual-enhanced magnetobiosensor based on cascaded nucleic acid circuits for sensitive, portable and digital quantitative detection of circulating miRNAs in serum by a personal glucose meter (PGM).


The Analyst ◽  
2015 ◽  
Vol 140 (4) ◽  
pp. 1161-1165 ◽  
Author(s):  
Qing Wang ◽  
Hui Wang ◽  
Xiaohai Yang ◽  
Kemin Wang ◽  
Rongjuan Liu ◽  
...  

A one-step assay for direct determination of α-amylase activity in serum and urine was developed using a portable personal glucose meter.


Sensors ◽  
2020 ◽  
Vol 20 (19) ◽  
pp. 5514
Author(s):  
Clara Abardía-Serrano ◽  
Rebeca Miranda-Castro ◽  
Noemí de-los-Santos-Álvarez ◽  
María Jesús Lobo-Castañón

A personal glucose meter (PGM)-based method for quantitative detection of a urinary nucleic acid biomarker in prostate cancer screening, the so-called PCA3, is reported herein. A sandwich-type genoassay is conducted on magnetic beads to collect the target from the sample by specific hybridization, making the assay appropriate for PCA3 detection in biological fluids. The success of the method hinges on the use of alkaline phosphatase (ALP) to link the amount of nucleic acid biomarker to the generation of glucose. In particular, specifically attached ALP molecules hydrolyze D-glucose-1-phosphate into D-glucose, thus enabling the amplification of the recorded signal on the personal glucose meter. The developed genoassay exhibits good sensitivity (3.3 ± 0.2 mg glucose dL−1 pM−1) for PCA3, with a dynamic range of 5 to 100 pM and a quantification limit of 5 pM. Likewise, it facilitates point-of-care testing of nucleic acid biomarkers by using off-the-shelf PGM instead of complex instrumentation involved in traditional laboratory-based tests.


The Analyst ◽  
2019 ◽  
Vol 144 (20) ◽  
pp. 6019-6024 ◽  
Author(s):  
Feifei Sun ◽  
Xiaomei Sun ◽  
Yijing Jia ◽  
Zhian Hu ◽  
Shenghao Xu ◽  
...  

We report a point-of-care immunosensor coupled with a rolling circle reaction and a personal glucose meter for sensitive detection of PSA.


2015 ◽  
Vol 64 ◽  
pp. 161-164 ◽  
Author(s):  
Qing Wang ◽  
Fang Liu ◽  
Xiaohai Yang ◽  
Kemin Wang ◽  
Hui Wang ◽  
...  

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