Understanding partial saturation in paper microfluidics enables alternative device architectures

2019 ◽  
Vol 11 (3) ◽  
pp. 336-345 ◽  
Author(s):  
Joshua R. Buser ◽  
Samantha A. Byrnes ◽  
Caitlin E. Anderson ◽  
Arielle J. Howell ◽  
Peter C. Kauffman ◽  
...  
Keyword(s):  
Microfluidic Devices ◽  
Diagnostic Assay ◽  
Partial Saturation ◽  
Paper Microfluidics ◽  
Paper Microfluidic ◽  
Assay Automation

A closer look at flow in paper microfluidic devices enables more advanced diagnostic assay automation using the same inexpensive materials.

scholarly journals Using printer ink color to control the behavior of paper microfluidics

Lab on a Chip ◽  
2019 ◽  
Vol 19 (11) ◽  
pp. 2000-2008 ◽  
Author(s):  
Joshua Potter ◽  
Philip Brisk ◽  
William H. Grover
Keyword(s):  
Microfluidic Devices ◽  
Paper Microfluidics ◽  
Paper Microfluidic

Different colors of wax inks behave differently in paper microfluidic devices, enabling the development of new color-based paper microfluidic components.

scholarly journals Paper Stacks for Uniform Rehydration of Dried Reagents in Paper Microfluidic Devices

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Debayan Das ◽  
Andrea Dsouza ◽  
Navjot Kaur ◽  
Shruti Soni ◽  
Bhushan J. Toley
Keyword(s):  
Unsolved Problem ◽  
Single Layer ◽  
Microfluidic Devices ◽  
Enzymatic Assay ◽  
Glucose Detection ◽  
Liquid Sample ◽  
Paper Microfluidics ◽  
Chemical Gradients ◽  
Dry Storage ◽  
Paper Microfluidic

Abstract Spatially uniform reconstitution of dried reagents is critical to the function of paper microfluidic devices. Advancing fluid fronts in paper microfluidic devices drive (convect) and concentrate rehydrated reagents to the edges, causing steep chemical gradients and imperfect mixing. This largely unsolved problem in paper microfluidics is exacerbated by increasing device dimensions. In this article, we demonstrate that mixing of dried reagents with a rehydrating fluid in paper microfluidics may be significantly enhanced by stacking paper layers having different wicking rates. Compared to single-layer paper membranes, stacking reduced the “non-reactive area”, i.e. area in which the reconstituted reagents did not interact with the rehydrating fluid, by as much as 97% in large (8 cm × 2 cm) paper membranes. A paper stack was designed to collect ~0.9 ml liquid sample and uniformly mix it with dried reagents. Applications of this technology are demonstrated in two areas: (i) collection and dry storage of sputum samples for tuberculosis testing, and (ii) salivary glucose detection using an enzymatic assay and colorimetric readout. Maximizing the interaction of liquids with dried reagents is central to enhancing the performance of all paper microfluidic devices; this technique is therefore likely to find important applications in paper microfluidics.

scholarly journals Citizen-Led Sampling to Monitor Phosphate Levels in Freshwater Environments Using a Simple Paper Microfluidic Device

2021 ◽  
Author(s):  
Samantha Richardson ◽  
Alexander Iles ◽  
Jeanette M. Rotchell ◽  
Tim Charlson ◽  
Annabel Hanson ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Mobile Technology ◽  
High Frequency ◽  
Microfluidic Devices ◽  
Cost Effective ◽  
Smartphone App ◽  
Test Device ◽  
Monitoring Campaign ◽  
Paper Microfluidic ◽  
Freshwater Environments

We demonstrate how a combination of paper microfluidic devices and handheld mobile technology can be used by citizen scientists to carry out a sustained water monitoring campaign. We have developed a paper-based analysis device and a 3 minute sampling workflow that requires no more than a container, a test device and a smartphone app. The contaminant measured in these pilots are phosphates, detectable down to 3 mg L<sup>-1</sup>. Together these allow volunteers to successfully carry out cost-effective, high frequency, phosphate monitoring over an extended geographies and periods.

scholarly journals Modelling-Guided Design of Paper Microfluidic Networks – A Case Study of Sequential Fluid Delivery

2020 ◽  
Author(s):  
Dharitri Rath ◽  
Bhushan Toley
Keyword(s):  
Mathematical Models ◽  
Low Cost ◽  
Microfluidic Devices ◽  
Computational Design ◽  
Engineering Problem ◽  
Richards Equation ◽  
Trial And Error ◽  
Microfluidic Networks ◽  
Paper Microfluidic ◽  
Flow Through

<p>Paper-based microfluidic devices are popular for their ability to automate multi-step assays for chemical or biological sensing at a low cost, but the design of paper microfluidic networks has largely relied on experimental trial and error. A few mathematical models of flow through paper microfluidic devices have been developed and have succeeded in explaining experimental flow behaviour. However, the reverse engineering problem of designing complex paper networks guided by appropriate mathematical models is largely unsolved. In this article, we demonstrate that a two-dimensional paper network (2DPN) designed to sequentially deliver three fluids to a test zone on the device can be computationally designed and experimentally implemented without trial and error. This was accomplished by three new developments in modelling flow through paper networks: i) coupling of the Richards equation of flow through porous media to the species transport equation, ii) modelling flow through assemblies of multiple paper materials (test membrane and wicking pad), and iii) incorporating limited-volume fluid sources. We demonstrate the application of this model in the optimal design of a paper-based signal-enhanced immunoassay for a malaria protein, P<i>f</i>HRP2. This work lays the foundation for the development of a computational design toolbox to aid in the design of paper microfluidic networks.</p>

Colorimetric analysis of the decomposition of S-nitrosothiols on paper-based microfluidic devices

The Analyst ◽  
2016 ◽  
Vol 141 (22) ◽  
pp. 6314-6320 ◽  
Author(s):  
Abdulghani Ismail ◽  
Marillya O. Araújo ◽  
Cyro L. S. Chagas ◽  
Sophie Griveau ◽  
Fanny D'Orlyé ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Microfluidic Devices ◽  
Colorimetric Analysis ◽  
Paper Microfluidic

A disposable paper microfluidic device was developed to analyse different S-nitrosothiols simultaneously decomposed by Hg2+ as well as UV, Vis and IR lamps.

Highly sensitive colorimetric detection of glucose and uric acid in biological fluids using chitosan-modified paper microfluidic devices

The Analyst ◽  
2016 ◽  
Vol 141 (15) ◽  
pp. 4749-4756 ◽  
Author(s):  
Ellen F. M. Gabriel ◽  
Paulo T. Garcia ◽  
Thiago M. G. Cardoso ◽  
Flavio M. Lopes ◽  
Felipe T. Martins ◽  
...  
Keyword(s):  
Uric Acid ◽  
Biological Fluids ◽  
Colorimetric Detection ◽  
Microfluidic Devices ◽  
Analytical Performance ◽  
Highly Sensitive ◽  
Colorimetric Measurements ◽  
Paper Microfluidic ◽  
Enzymatic Bioassays

This paper describes the modification of microfluidic paper-based analytical devices (μPADs) with chitosan to improve the analytical performance of colorimetric measurements associated with enzymatic bioassays.

A simple cantilever system for measurement of flow rates in paper microfluidic devices

2019 ◽  
Vol 1 (2) ◽  
pp. 025019
Author(s):  
Omar Mohd ◽  
Mohamad S Sotoudegan ◽  
Frances S Ligler ◽  
Glenn M Walker
Keyword(s):  
Microfluidic Devices ◽  
Flow Rates ◽  
Paper Microfluidic
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