Integrated paper-based microfluidic devices for point-of-care testing

2018 ◽  
Vol 10 (29) ◽  
pp. 3567-3581 ◽  
Author(s):  
Tian Tian ◽  
Yunpeng Bi ◽  
Xing Xu ◽  
Zhi Zhu ◽  
Chaoyong Yang
Keyword(s):  
Signal Transduction ◽  
Point Of Care ◽  
Sample Pretreatment ◽  
Microfluidic Devices ◽  
Point Of Care Testing

This review highlights the developments, accomplishments and challenges of integrated μPADs, including sample pretreatment, signal transduction/amplification and results output.

scholarly journals Disposable Voltammetric Immunosensors Integrated with Microfluidic Platforms for Biomedical, Agricultural and Food Analyses: A Review

Sensors ◽  
2018 ◽  
Vol 18 (12) ◽  
pp. 4124 ◽  
Author(s):  
Fabiana Felix ◽  
Alexandre Baccaro ◽  
Lúcio Angnes
Keyword(s):  
Quality Management ◽  
Signal Amplification ◽  
Screen Printing ◽  
Point Of Care ◽  
Microfluidic Devices ◽  
Strong Interactions ◽  
Point Of Care Testing ◽  
Microfluidic Platforms ◽  
Broad Variety ◽  
Interesting Alternative

Disposable immunosensors are analytical devices used for the quantification of a broad variety of analytes in different areas such as clinical, environmental, agricultural and food quality management. They detect the analytes by means of the strong interactions between antibodies and antigens, which provide concentration-dependent signals. For the herein highlighted voltammetric immunosensors, the analytical measurements are due to changes in the electrical signals on the surface of the transducers. The possibility of using disposable and miniaturized immunoassays is a very interesting alternative for voltammetric analyses, mainly, when associated with screen-printing technologies (screen-printed electrodes, SPEs), and microfluidic platforms. The aim of this paper is to discuss a carefully selected literature about different examples of SPEs-based immunosensors associated with microfluidic technologies for diseases, food, agricultural and environmental analysis. Technological aspects of the development of the voltammetric immunoassays such as the signal amplification, construction of paper-based microfluidic platforms and the utilization of microfluidic devices for point-of-care testing will be presented as well.

scholarly journals Elasto-Magnetic Pumps Integrated within Microfluidic Devices

2021 ◽  
Vol 4 (1) ◽  
pp. 48
Author(s):  
Jacob L. Binsley ◽  
Elizabeth L. Martin ◽  
Thomas O. Myers ◽  
Stefano Pagliara ◽  
Feodor Y. Ogrin
Keyword(s):  
Magnetic System ◽  
Point Of Care ◽  
Microfluidic Channel ◽  
Lab On A Chip ◽  
Microfluidic Devices ◽  
Point Of Care Testing ◽  
Ongoing Research ◽  
Flow Rates ◽  
Pumping System ◽  
Oscillating Magnetic Field

Many lab-on-a-chip devices require a connection to an external pumping system in order to perform their function. While this is not problematic in typical laboratory environments, it is not always practical when applied to point-of-care testing, which is best utilized outside of the laboratory. Therefore, there has been a large amount of ongoing research into producing integrated microfluidic components capable of generating effective fluid flow from on-board the device. This research aims to introduce a system that can produce practical flow rates, and be easily fabricated and actuated using readily available techniques and materials. We show how an asymmetric elasto-magnetic system, inspired by Purcell’s three-link swimmer, can provide this solution through the generation of non-reciprocal motion in an enclosed environment. The device is fabricated monolithically within a microfluidic channel at the time of manufacture, and is actuated using a weak, oscillating magnetic field. The flow rate can be altered dynamically, and the direction of the resultant flow can be controlled by adjusting the frequency of the driving field. The device has been proven, experimentally and numerically, to operate effectively when applied to fluids with a range of viscosities. Such a device may be able to replace external pumping systems in portable applications.

scholarly journals Microfluidic devices powered by integrated elasto-magnetic pumps

Lab on a Chip ◽  
2020 ◽  
Vol 20 (22) ◽  
pp. 4285-4295
Author(s):  
Jacob L. Binsley ◽  
Elizabeth L. Martin ◽  
Thomas O. Myers ◽  
Stefano Pagliara ◽  
Feodor Y. Ogrin
Keyword(s):  
Point Of Care ◽  
Microfluidic Devices ◽  
Point Of Care Testing

Integrated elasto-magnetic pumps power portable microfluidic devices for point of care testing.

Advances in paper-based sample pretreatment for point-of-care testing

2016 ◽  
Vol 37 (4) ◽  
pp. 411-428 ◽  
Author(s):  
Rui Hua Tang ◽  
Hui Yang ◽  
Jane Ru Choi ◽  
Yan Gong ◽  
Shang Sheng Feng ◽  
...  
Keyword(s):  
Point Of Care ◽  
Sample Pretreatment ◽  
Point Of Care Testing

scholarly journals A Compact, Syringe-Assisted, Vacuum-Driven Micropumping Device

Micromachines ◽  
2019 ◽  
Vol 10 (8) ◽  
pp. 543 ◽  
Author(s):  
Anyang Wang ◽  
Domin Koh ◽  
Philip Schneider ◽  
Evan Breloff ◽  
Kwang W. Oh
Keyword(s):  
Microfluidic Device ◽  
Point Of Care ◽  
Microfluidic Devices ◽  
Microfluidic Channels ◽  
Constant Flow ◽  
Proof Of Concept ◽  
Point Of Care Testing ◽  
Microfluidic Mixing ◽  
Pumping System ◽  
Dead End

In this paper, a simple syringe‑assisted pumping method is introduced. The proposed fluidic micropumping system can be used instead of a conventional pumping system which tends to be large, bulky, and expensive. The micropump was designed separately from the microfluidic channels and directly bonded to the outlet of the microfluidic device. The pump components were composed of a dead‑end channel which was surrounded by a microchamber. A syringe was then connected to the pump structure by a short tube, and the syringe plunger was manually pulled out to generate low pressure inside the microchamber. Once the sample was loaded in the inlet, air inside the channel diffused into the microchamber through the PDMS (polydimethylsiloxane) wall, acting as a dragging force and pulling the sample toward the outlet. A constant flow with a rate that ranged from 0.8 nl · s − 1 to 7.5 nl · s − 1 was achieved as a function of the geometry of the pump, i.e., the PDMS wall thickness and the diffusion area. As a proof-of-concept, microfluidic mixing was demonstrated without backflow. This method enables pumping for point-of-care testing (POCT) with greater flexibility in hand-held PDMS microfluidic devices.

Magnetic nanoparticles in microfluidics-based diagnostics: an appraisal

Nanomedicine ◽  
2021 ◽  
Author(s):  
Smriti Sharma ◽  
Vinayak Bhatia
Keyword(s):  
Developing Countries ◽  
Magnetic Nanoparticles ◽  
Low Income ◽  
Point Of Care ◽  
Microfluidic Devices ◽  
Point Of Care Testing ◽  
Microfluidic Mixing ◽  
Future Directions ◽  
Sensing Systems ◽  
On Chip

The use of magnetic nanoparticles (MNPs) in microfluidics based diagnostics is a classic case of micro-, nano- and bio-technology coming together to design extremely controllable, reproducible, and scalable nano and micro ‘ on-chip bio sensing systems.’ In this review, applications of MNPs in microfluidics ranging from molecular diagnostics and immunodiagnostics to clinical uses have been examined. In addition, microfluidic mixing and capture of analytes using MNPs, and MNPs as carriers in microfluidic devices has been investigated. Finally, the challenges and future directions of this upcoming field have been summarized. The use of MNP-based microfluidic devices, will help in developing decentralized or ‘ point of care’ testing globally, contributing to affordable healthcare, particularly, for middle- and low-income developing countries.

Towards practical sample preparation in point-of-care testing: user-friendly microfluidic devices

Lab on a Chip ◽  
2020 ◽  
Vol 20 (7) ◽  
pp. 1191-1203 ◽  
Author(s):  
Juhwan Park ◽  
Dong Hyun Han ◽  
Je-Kyun Park
Keyword(s):  
Sample Preparation ◽  
Point Of Care ◽  
Microfluidic Devices ◽  
Future Perspectives ◽  
Point Of Care Testing ◽  
User Friendly

An overview and future perspectives of user-friendly microfluidic devices have been reported in terms of practical sample preparation in point-of-care testing.

scholarly journals Polymer microfluidic devices: an overview of fabrication methods

2017 ◽  
Vol 1 (1) ◽  
pp. 67-79 ◽  
Author(s):  
Raquel O. Rodrigues ◽  
Rui Lima ◽  
Helder T. Gomes ◽  
Adrián M. T. Silva
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Lab On A Chip ◽  
Microfluidic Devices ◽  
Point Of Care Testing ◽  
Standard Methods ◽  
Time Consumption ◽  
Advantages And Disadvantages ◽  
Fundamental Research ◽  
Microfabrication Techniques

The amount of applications associated with microfluidic devices is increasing since the introduction of Lab-on-a-chip devices in the 1990s, especially regarding biomedical and clinical fields. However, in order for this technology to leave the fundamental research and become a day-life technology (e.g., as point-of-care testing), it needs to be disposable and reasonably less expensive. Polymers, due to their several advantages, such as easier microfabrication and low-cost, fill these needs. Several methods are reported regarding microfabrication and, thus, the main aim of the present work is to provide an overview of the most relevant microfabrication techniques found in literature employing polymers, clarifying also the main advantages and disadvantages of each technique and especially considering their cost and time-consumption. Moreover, a future outlook of low-cost microfabrication techniques and standard methods is provided.

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