Simultaneous extraction of acidic and basic drugs via on-chip electromembrane extraction using a single-compartment microfluidic device

The Analyst ◽  
2019 ◽  
Vol 144 (4) ◽  
pp. 1159-1166 ◽  
Author(s):  
Fereshteh Zarghampour ◽  
Yadollah Yamini ◽  
Mahroo Baharfar ◽  
Mohammad Faraji
Keyword(s):  
Microfluidic Device ◽  
Biological Fluids ◽  
Basic Drugs ◽  
Simultaneous Extraction ◽  
Single Compartment ◽  
Electromembrane Extraction ◽  
On Chip

A chip was designed for simultaneous extraction of acidic and basic drugs from biological fluids.

Simultaneous extraction of acidic and basic drugs via on-chip electromembrane extraction

2016 ◽  
Vol 937 ◽  
pp. 61-68 ◽  
Author(s):  
Yousef Abdossalami Asl ◽  
Yadollah Yamini ◽  
Shahram Seidi ◽  
Maryam Rezazadeh
Keyword(s):  
Basic Drugs ◽  
Simultaneous Extraction ◽  
Electromembrane Extraction ◽  
On Chip

On-chip pulsed electromembrane extraction as a new concept for analysis of biological fluids in a small device

2017 ◽  
Vol 1527 ◽  
pp. 1-9 ◽  
Author(s):  
Monireh Karami ◽  
Yadollah Yamini ◽  
Yousef Abdossalami Asl ◽  
Maryam Rezazadeh
Keyword(s):  
Biological Fluids ◽  
Small Device ◽  
Electromembrane Extraction ◽  
On Chip

scholarly journals Design and Manufacturing of a Disposable, Cyclo-Olefin Copolymer, Microfluidic Device for a Biosensor †

Sensors ◽  
2019 ◽  
Vol 19 (5) ◽  
pp. 1178 ◽  
Author(s):  
Jorge Prada ◽  
Christina Cordes ◽  
Carsten Harms ◽  
Walter Lang
Keyword(s):  
Microfluidic Device ◽  
Heating Temperature ◽  
Low Cost ◽  
Reaction Chamber ◽  
Microfluidic System ◽  
Heating Process ◽  
Design And Manufacturing ◽  
On Chip ◽  
Working Parameters ◽  
Auto Fluorescence

This contribution outlines the design and manufacturing of a microfluidic device implemented as a biosensor for retrieval and detection of bacteria RNA. The device is fully made of Cyclo-Olefin Copolymer (COC), which features low auto-fluorescence, biocompatibility and manufacturability by hot-embossing. The RNA retrieval was carried on after bacteria heat-lysis by an on-chip micro-heater, whose function was characterized at different working parameters. Carbon resistive temperature sensors were tested, characterized and printed on the biochip sealing film to monitor the heating process. Off-chip and on-chip processed RNA were hybridized with capture probes on the reaction chamber surface and identification was achieved by detection of fluorescence tags. The application of the mentioned techniques and materials proved to allow the development of low-cost, disposable albeit multi-functional microfluidic system, performing heating, temperature sensing and chemical reaction processes in the same device. By proving its effectiveness, this device contributes a reference to show the integration potential of fully thermoplastic devices in biosensor systems.

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