Low-voltage electrically-enhanced microextraction as a novel technique for simultaneous extraction of acidic and basic drugs from biological fluids

2012 ◽  
Vol 1243 ◽  
pp. 6-13 ◽  
Author(s):  
Shahram Seidi ◽  
Yadollah Yamini ◽  
Maryam Rezazadeh ◽  
Ali Esrafili
Keyword(s):  
Low Voltage ◽  
Biological Fluids ◽  
Basic Drugs ◽  
Simultaneous Extraction ◽  
Novel Technique ◽  
Electrically Enhanced

Simultaneous extraction of acidic and basic drugs via on-chip electromembrane extraction using a single-compartment microfluidic device

The Analyst ◽  
2019 ◽  
Vol 144 (4) ◽  
pp. 1159-1166 ◽  
Author(s):  
Fereshteh Zarghampour ◽  
Yadollah Yamini ◽  
Mahroo Baharfar ◽  
Mohammad Faraji
Keyword(s):  
Microfluidic Device ◽  
Biological Fluids ◽  
Basic Drugs ◽  
Simultaneous Extraction ◽  
Single Compartment ◽  
Electromembrane Extraction ◽  
On Chip

A chip was designed for simultaneous extraction of acidic and basic drugs from biological fluids.

Determination of Ibuprofen and Phenylephrine in Tablets by High-Performance Thin Layer Chromatography and in Plasma by High-Performance Liquid Chromatography with Diode Array Detection

2019 ◽  
Vol 57 (7) ◽  
pp. 592-599
Author(s):  
Marwa A A Ragab ◽  
Mohamed H Abdel-Hay ◽  
Hytham M Ahmed ◽  
Sara M Mohyeldin
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
High Performance ◽  
Biological Fluids ◽  
Array Detector ◽  
Diode Array ◽  
Simultaneous Extraction ◽  
Layer Chromatography

Abstract Two chromatographic methods (high performance thin layer chromatography (HPTLC) and high performance liquid chromatography–diode array detector (HPLC-DAD)), were addressed for the analysis of a mixture consisted of phenylephrine hydrochloride and ibuprofen in two forms bulk and their combined dosage form. This binary mixture is considered to be a challenging one as the two drugs differ greatly in their chemical and physical properties. Not only this affects their simultaneous analysis, but also hinders their simultaneous extraction from biological fluids as plasma. That is the reason the literature lacks any report for the simultaneous extraction and analysis of these drugs from biological fluids. The concentration ranges of both drugs were 0.1–2.5 μg/spot and 0.1–100 μg/mL by HPTLC and HPLC, respectively. Not only was the HPLC-DAD method applied to the investigated drugs determination in pharmaceutical preparations, but also in spiked human plasma. Extensive study was conducted to optimize their simultaneous extraction from plasma as it was a crucial step for the in vivo analysis. The results obtained by proposed methods and a reference one were statistically comparable by analysis of variance test. No significant difference was recorded between the mean percent levels determined by the proposed methods and the reference one.

Simultaneous extraction of acidic and basic drugs via on-chip electromembrane extraction

2016 ◽  
Vol 937 ◽  
pp. 61-68 ◽  
Author(s):  
Yousef Abdossalami Asl ◽  
Yadollah Yamini ◽  
Shahram Seidi ◽  
Maryam Rezazadeh
Keyword(s):  
Basic Drugs ◽  
Simultaneous Extraction ◽  
Electromembrane Extraction ◽  
On Chip

Simultaneous extraction of acidic and basic drugs from urine using mixed-mode monolithic silica spin column bonded with octadecyl and cation-exchange group

2011 ◽  
Vol 34 (16-17) ◽  
pp. 2232-2239 ◽  
Author(s):  
Akira Namera ◽  
Shinobu Yamamoto ◽  
Takeshi Saito ◽  
Shota Miyazaki ◽  
Hiroshi Oikawa ◽  
...  
Keyword(s):  
Cation Exchange ◽  
Mixed Mode ◽  
Basic Drugs ◽  
Monolithic Silica ◽  
Simultaneous Extraction ◽  
Exchange Group ◽  
Spin Column

Simultaneous extraction of acidic and basic drugs at neutral sample pH: A novel electro-mediated microextraction approach

2010 ◽  
Vol 1217 (43) ◽  
pp. 6661-6667 ◽  
Author(s):  
Chanbasha Basheer ◽  
Jingyi Lee ◽  
Stig Pedersen-Bjergaard ◽  
Knut Einar Rasmussen ◽  
Hian Kee Lee
Keyword(s):  
Basic Drugs ◽  
Simultaneous Extraction
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