scholarly journals Chromatin dynamics underlying latent responses to xenobiotics

2018 ◽  
Vol 7 (4) ◽  
pp. 606-617
Author(s):  
Jonathan Moggs ◽  
Rémi Terranova
Keyword(s):  
Adverse Effects ◽  
Somatic Tissue ◽  
Chromatin Dynamics ◽  
Delayed Onset ◽  
Latent Responses

Xenobiotic-induced perturbations of somatic tissue or germline epigenomes may underlie delayed-onset and long-lasting adverse effects.

Delayed Onset of Central Diabetes Insipidus With Ketamine Sedation: A Report of 2 Cases

2019 ◽  
pp. 089719001988226 ◽  
Author(s):  
Leah B. Herity ◽  
Cassandra Baker ◽  
Christin Kim ◽  
Denise K. Lowe ◽  
William D. Cahoon
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Adverse Effects ◽  
Diabetes Insipidus ◽  
Drug Effect ◽  
Laboratory Data ◽  
Multimodal Analgesia ◽  
Central Diabetes Insipidus ◽  
Probability Scale ◽  
Delayed Onset

Ketamine is being prescribed with greater frequency due to an emphasis on multimodal analgesia. With increasing use, uncommon adverse effects associated with ketamine are likely to surface. Limited reports of transient central diabetes insipidus (DI) occurring early after initiation (ie, within 10 hours) of ketamine have been reported. We present 2 cases of delayed onset (32 hours or more after initiation), ketamine-induced, transient central DI in patients cannulated for venovenous extracorporeal membranous oxygenation. No other causes of central DI were determined based upon physical examination or laboratory data, and both patients responded to treatment with desmopressin/vasopressin. The Naranjo adverse drug reaction probability scale noted a probable causation for each case. These cases demonstrate the possibility of a rare but serious complication of ketamine. Improvement after discontinuation of ketamine and administration of desmopressin/vasopressin appear to support a drug–effect association.

scholarly journals Delayed onset immune related adverse effects (IRAEs) of pembrolizumab in non-small cell lung cancer

2019 ◽  
Vol 30 ◽  
pp. v620
Author(s):  
H. Yan ◽  
Y. Jiang ◽  
M.K. Luong ◽  
N. Naban ◽  
C. Kane ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Adverse Effects ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Delayed Onset

Delayed Onset of Maternal Affection After Childbirth

1980 ◽  
Vol 136 (4) ◽  
pp. 347-353 ◽  
Author(s):  
Kay Mordecai Robson ◽  
R. Kumar
Keyword(s):  
Adverse Effects ◽  
Emotional Reaction ◽  
Emotional Reactions ◽  
Delayed Onset ◽  
Post Natal Depression ◽  
Clinically Depressed ◽  
First Time ◽  
Primiparous Women

SummaryInformation about perceptions of labour and delivery and about immediate emotional reactions to their newborn babies was obtained from two groups of primiparous women (n = 112 and n = 41) and from 40 multiparae. About 40 per cent of primiparae and 25 per cent of multiparae recalled that their predominant emotional reaction when holding their babies for the very first time had been one of indifference. Maternal affection was more likely to be lacking after delivery if the mother had had a forewater amniotomy and had, in addition, either experienced a painful and unpleasant labour or been given more than 125 mg of pethidine.Most mothers developed affection for their babies within a week of delivery and, in all groups of subjects, no longer term adverse effects were seen, such as post-natal depression or aggressive impulses directed at the baby. Three months post-natally it was, however, found that a mother was more likely to express feelings of dislike or indifference towards her baby if she was clinically depressed at the time.

The Influence of Specimen Thickness in Quantitative Electron Energy Loss Spectroscopy

1980 ◽  
Vol 38 ◽  
pp. 112-113
Author(s):  
Nestor J. Zaluzec
Keyword(s):  
Quantitative Analysis ◽  
Adverse Effects ◽  
Energy Loss ◽  
Electron Energy ◽  
Electron Energy Loss Spectroscopy ◽  
Materials Science ◽  
Light Element ◽  
Specimen Thickness ◽  
Element Analysis ◽  
Electron Energy Loss

The application of electron energy loss spectroscopy (EELS) to light element analysis is rapidly becoming an important aspect of the microcharacterization of solids in materials science, however relatively stringent requirements exist on the specimen thickness under which one can obtain EELS data due to the adverse effects of multiple inelastic scattering.1,2 This study was initiated to determine the limitations on quantitative analysis of EELS data due to specimen thickness.

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