Mitochondria and lysosome-targetable fluorescent probes for HOCl: recent advances and perspectives

2018 ◽  
Vol 6 (12) ◽  
pp. 1716-1733 ◽  
Author(s):  
Mingguang Ren ◽  
Kai Zhou ◽  
Longwei He ◽  
Weiying Lin
Keyword(s):  
Fluorescent Probes ◽  
Design Strategies ◽  
Recent Advances ◽  
Bio Imaging

We highlight the representative cases of fluorescent HOCl probes with mitochondria and lysosome-targetable ability. The discussion includes their design strategies, sensing mechanisms, and applications in bio-imaging of HOCl in organelles.

Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging

2018 ◽  
Vol 47 (18) ◽  
pp. 7140-7180 ◽  
Author(s):  
Hong-Wen Liu ◽  
Lanlan Chen ◽  
Chengyan Xu ◽  
Zhe Li ◽  
Haiyang Zhang ◽  
...  
Keyword(s):  
Small Molecule ◽  
Fluorescent Probes ◽  
Cancer Imaging ◽  
Design Strategies ◽  
Recent Advances

An overview of recent advances in small-molecule enzymatic fluorescent probes for cancer imaging, including design strategies and cancer imaging applications.

Importance of Bodipy-based Chemosensors for Cations and Anions in Bioimaging Applications

2020 ◽  
Vol 17 ◽  
Author(s):  
Ahmed Nuri Kursunlu ◽  
Elif Bastug ◽  
Ersin Guler
Keyword(s):  
Photophysical Properties ◽  
Direct Determination ◽  
Spectroscopic Properties ◽  
Selective Detection ◽  
Fluorescent Chemosensors ◽  
Design Strategies ◽  
Online Activity ◽  
Fluorescence Studies ◽  
Bio Imaging ◽  
Living Organisms

Background: Chemosensor compounds are useful for sensitive selective detection of cations and anions with fluorophore groups in an attempt to develop the effective selectivity of the sensors. Although familiar fluorescent sensors utilizing inter-molecular interactions with the cations and anions, an extraordinary endeavor was executed the preparation of fluorescent-based sensor compounds. 4,4-difluoro-4- bora-3a,4a-diaza-s-indacene (Bodipy) and its derivatives were firstly used as an agent in the imaging of biomolecules due to their interesting structures, complexation, and fluorogenic properties. Among the fluorescent chemosensors used for cations and anions, Bodipy-based probes stand out owing to the excellent properties such as sharp emission profile, high stability, etc. In this review, we emphasize the Bodipy-based chemosensor compounds, which have been used to image cations and anions in living cells, because of as well as the biocompatibility and spectroscopic properties. Methods: Research and online content related to chemosensor online activity is reviewed. The advances, sensing mechanisms and design strategies of the fluorophore exploiting selective detection of some cation and anions with Bodipy-based chemosensors are explained. It could be claimed that the using of Bodipy-based chemosensors is very important for cations and anions in bio-imaging applications. Results: Molecular sensors or chemosensors are molecules that show a change can be detected when affected by the analyte. They are capable of producing a measurable signal when they are selective for a particular molecule. Molecular and ion recognition that it is important in biological systems such as enzymes, genes, environment, and chemical fields. Due to the toxic properties of many heavy metal ions, it is of great importance to identify these metals due to their harmful effects on living metabolism and the pollution they create in the environment. This process can be performed with analytical methods based on atomic absorption and emission. The fluorescence methods among chemosensor systems have many advantages such as sensitivity, selectivity, low price, simplicity of using the instrument and direct determination in solutions. The fluorescence studies can be applied at nanomolar concentrations. Conclusion: During a few decades, a lot of Bodipy-based chemosensors for the detection of cations & anions have been investigated in bio-imaging applications. For the Bodipy-based fluorescent chemosensors, the Bodipy derivatives were prepared by different ligand groups for the illumination of the photophysical and photochemical properties. The synthesized Bodipy-based chemosensors have remarkable photophysical properties, such as a high quantum yield, strong molar absorption coefficient etc. Moreover, these chemosensors were successfully implemented on living organisms for the detection of analytes.

Recent advances in quinazolinones as an emerging molecular platform for luminescent materials and bioimaging

2021 ◽  
Vol 8 (8) ◽  
pp. 1867-1889
Author(s):  
Zhiming Xing ◽  
Wanhui Wu ◽  
Yongxiang Miao ◽  
Yingqun Tang ◽  
Youkang Zhou ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Biological Imaging ◽  
Luminescence Properties ◽  
Luminescent Materials ◽  
Future Outlook ◽  
Recent Advances

This review summarized recent advances relating to the luminescence properties of quinazolinones and their applications in fluorescent probes, biological imaging and luminescent materials. Their future outlook is also included.

scholarly journals Small-molecule fluorescence-based probes for interrogating major organ diseases

2021 ◽  
Author(s):  
Hai-Hao Han ◽  
He Tian ◽  
Yi Zang ◽  
Adam C. Sedgwick ◽  
Jia Li ◽  
...  
Keyword(s):  
Small Molecule ◽  
Fluorescent Probes ◽  
Recent Advances ◽  
Major Organ

This tutorial review describes recent advances involving small molecule fluorescent probes designed to aid in the study of major organ diseases.

scholarly journals Stimuli-responsive nanobubbles for biomedical applications

2021 ◽  
Author(s):  
Ranhua Xiong ◽  
Ronald X. Xu ◽  
Chaobo Huang ◽  
Stefaan De Smedt ◽  
Kevin Braeckmans
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Stimuli Responsive ◽  
Recent Advances ◽  
Tumor Tissues ◽  
Bio Imaging

This review presents an overview of the recent advances in the development of stimuli-responsive nanobubbles and their novel biomedical applications including bio-imaging, drug delivery and ablation of tumor tissues.

Recent advances in molecular logic gate chemosensors based on luminescent metal organic frameworks

2021 ◽  
Author(s):  
Bei Li ◽  
Dongsheng Zhao ◽  
Feng Wang ◽  
Xiaoxian Zhang ◽  
Wenqian Li ◽  
...  
Keyword(s):  
Logic Gate ◽  
Metal Organic Frameworks ◽  
Logic Gates ◽  
Design Strategies ◽  
Molecular Logic Gate ◽  
Future Developments ◽  
Molecular Logic ◽  
Molecular Logic Gates ◽  
Recent Advances ◽  
Metal Organic

This review covers the latest advancements of molecular logic gates based on LMOF. The classification, design strategies, related sensing mechanisms, future developments, and challenges of LMOFs-based logic gates are discussed.

Theoretical investigation and design of two-photon fluorescent probes for visualizing β-galactosidase activity in living cells

RSC Advances ◽  
2016 ◽  
Vol 6 (75) ◽  
pp. 70960-70971 ◽  
Author(s):  
Chun Zhang ◽  
Dan Wang ◽  
Li Zhang ◽  
Jing-Fu Guo ◽  
Ai-Min Ren
Keyword(s):  
Theoretical Investigation ◽  
Fluorescent Probes ◽  
Living Cells ◽  
Galactosidase Activity ◽  
Two Photon ◽  
Bio Imaging

The two-photon fluorescent probes show dual signal for β-gal bio-imaging.

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