In vivotumor active cancer targeting and CT-fluorescence dual-modal imaging with nanoprobe based on gold nanorods and InP/ZnS quantum dots

2018 ◽  
Vol 6 (17) ◽  
pp. 2574-2583 ◽  
Author(s):  
Lin Zhang ◽  
Xiao-Quan Yang ◽  
Jie An ◽  
Sun-Duo Zhao ◽  
Tian-Yu Zhao ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Gold Nanorods ◽  
Gold Nanorod ◽  
Active Targeting ◽  
Cancer Targeting ◽  
Multifunctional Nanoprobe ◽  
Active Cancer

Gold nanorod, InP/ZnS QD and c(RGDfC) based multifunctional nanoprobe for dual-modal imaging of active targeting of tumorsin vivo.

In vivo cancer targeting and imaging with semiconductor quantum dots

2004 ◽  
Vol 22 (8) ◽  
pp. 969-976 ◽  
Author(s):  
Xiaohu Gao ◽  
Yuanyuan Cui ◽  
Richard M Levenson ◽  
Leland W K Chung ◽  
Shuming Nie
Keyword(s):  
Quantum Dots ◽  
Semiconductor Quantum Dots ◽  
Cancer Targeting

siRNA liposome-gold nanorod vectors for multispectral optoacoustic tomography theranostics

Nanoscale ◽  
2014 ◽  
Vol 6 (22) ◽  
pp. 13451-13456 ◽  
Author(s):  
Adrian Taruttis ◽  
Neus Lozano ◽  
Antonio Nunes ◽  
Dhifaf A. Jasim ◽  
Nicolas Beziere ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Gold Nanorods ◽  
Gold Nanorod ◽  
Vector System ◽  
Optoacoustic Tomography

This study describes the simultaneous in vivo optoacousic imaging and siRNA-mediated gene silencing capabilities of a model theranostic vector system between liposomes and gold nanorods.

Synthesis of cRGD-peptide conjugated near-infrared CdTe/ZnSe core–shell quantum dots for in vivo cancer targeting and imaging

2010 ◽  
Vol 46 (38) ◽  
pp. 7136 ◽  
Author(s):  
Ken-Tye Yong ◽  
Indrajit Roy ◽  
Wing-Cheung Law ◽  
Rui Hu
Keyword(s):  
Quantum Dots ◽  
Near Infrared ◽  
Core Shell ◽  
Cancer Targeting

In vivo cancer targeting and fluorescence-CT dual-mode imaging with nanoprobes based on silver sulfide quantum dots and iodinated oil

Nanoscale ◽  
2015 ◽  
Vol 7 (46) ◽  
pp. 19484-19492 ◽  
Author(s):  
Meng-Yao Qin ◽  
Xiao-Quan Yang ◽  
Kan Wang ◽  
Xiao-Shuai Zhang ◽  
Ji-Tao Song ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Silver Sulfide ◽  
Cancer Targeting ◽  
Dual Mode

MicroCT Imaging and In Vivo Temperature Elevations in Implanted Prostatic Tumors in Laser Photothermal Therapy Using Gold Nanorods

2012 ◽  
Vol 3 (2) ◽  
Author(s):  
N. Manuchehrabadi ◽  
A. Attaluri ◽  
H. Cai ◽  
R. Edziah ◽  
E. Lalanne ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Imaging System ◽  
Laser Energy ◽  
Gold Nanorod ◽  
Laser Irradiance ◽  
Theoretical Simulation ◽  
Microct Imaging ◽  
Laser Photothermal Therapy

In this study, in vivo animal experiments are performed on implanted xenograph prostatic tumors in nude mice to investigate enhanced laser energy absorption in the tumors by an intratumoral injection of gold nanorod solutions. In vivo temperature mapping of the tumors during laser photothermal therapy has shown the feasibility of elevating tumor temperatures higher than 50 °C using only 0.1 ml nanorod solution and a low laser irradiance of 1.6 W/cm2 incident on the tumor surface. The temperature profile suggests that normal tumor tissue still absorbs some amount of the laser energy without nanorod presence; however, the injected nanorods ensure that almost all the laser energy is absorbed and confined to the targeted tumors. The inverse relationship between the temperature elevations and the tumor size implies a relatively uniform spreading of the nanorods to the entire tumor, which is also shown by microcomputed tomography (microCT) imaging analyses. The feasibility of detecting 250 OD gold nanorod solution injected to the tumors is demonstrated via a high resolution microCT imaging system. Compared to other nanostructures, the gold nanorods used in this study do not accumulate surrounding the injection site. The relatively uniform deposition of the nanorods in the tumors observed by the microCT scans can be helpful in future study in simplifying theoretical simulation of temperature elevations in tumors during laser photothermal therapy.

Trends in Nanotechnology for in vivo Cancer Diagnosis: Products and Patents

2020 ◽  
Vol 26 (18) ◽  
pp. 2167-2181
Author(s):  
Tatielle do Nascimento ◽  
Melanie Tavares ◽  
Mariana S.S.B. Monteiro ◽  
Ralph Santos-Oliveira ◽  
Adriane R. Todeschini ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Quantum Dots ◽  
Magnetic Resonance ◽  
Metal Nanoparticles ◽  
Cancer Diagnosis ◽  
Imaging Techniques ◽  
Tumor Detection ◽  
Abnormal Growth ◽  
Pharmaceutical Nanotechnology

Background: Cancer is a set of diseases formed by abnormal growth of cells leading to the formation of the tumor. The diagnosis can be made through symptoms’ evaluation or imaging tests, however, the techniques are limited and the tumor detection may be late. Thus, pharmaceutical nanotechnology has emerged to optimize the cancer diagnosis through nanostructured contrast agent’s development. Objective: This review aims to identify commercialized nanomedicines and patents for cancer diagnosis. Methods: The databases used for scientific articles research were Pubmed, Science Direct, Scielo and Lilacs. Research on companies’ websites and articles for the recognition of commercial nanomedicines was performed. The Derwent tool was applied for patent research. Results: This article aimed to research on nanosystems based on nanoparticles, dendrimers, liposomes, composites and quantum dots, associated to imaging techniques. Commercialized products based on metal and composite nanoparticles, associated with magnetic resonance and computed tomography, have been observed. The research conducted through Derwent tool displayed a small number of patents using nanotechnology for cancer diagnosis. Among these patents, the most significant number was related to the use of systems based on metal nanoparticles, composites and quantum dots. Conclusion: Although few systems are found in the market and patented, nanotechnology appears as a promising field for the development of new nanosystems in order to optimize and accelerate the cancer diagnosis.

In Vivo Deep-Brain Structural and Hemodynamic Multiphoton Microscopy Enabled by Quantum Dots

Nano Letters ◽  
2019 ◽  
Vol 19 (8) ◽  
pp. 5260-5265 ◽  
Author(s):  
Hongji Liu ◽  
Xiangquan Deng ◽  
Shen Tong ◽  
Chen He ◽  
Hui Cheng ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Multiphoton Microscopy ◽  
Deep Brain

scholarly journals Synthesis and Characterization of Polyvinylpyrrolidone-Modified ZnO Quantum Dots and Their In Vitro Photodynamic Tumor Suppressive Action

2021 ◽  
Vol 22 (15) ◽  
pp. 8106
Author(s):  
Tianming Song ◽  
Yawei Qu ◽  
Zhe Ren ◽  
Shuang Yu ◽  
Mingjian Sun ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Photodynamic Therapy ◽  
Inhibitory Effect ◽  
Therapeutic Effects ◽  
In Vivo Experiments ◽  
Potential Applications ◽  
Zno Quantum Dots ◽  
Zno Qds

Despite the numerous available treatments for cancer, many patients succumb to side effects and reoccurrence. Zinc oxide (ZnO) quantum dots (QDs) are inexpensive inorganic nanomaterials with potential applications in photodynamic therapy. To verify the photoluminescence of ZnO QDs and determine their inhibitory effect on tumors, we synthesized and characterized ZnO QDs modified with polyvinylpyrrolidone. The photoluminescent properties and reactive oxygen species levels of these ZnO/PVP QDs were also measured. Finally, in vitro and in vivo experiments were performed to test their photodynamic therapeutic effects in SW480 cancer cells and female nude mice. Our results indicate that the ZnO QDs had good photoluminescence and exerted an obvious inhibitory effect on SW480 tumor cells. These findings illustrate the potential applications of ZnO QDs in the fields of photoluminescence and photodynamic therapy.

Sign in / Sign up

Export Citation Format

Share Document