siRNA liposome-gold nanorod vectors for multispectral optoacoustic tomography theranostics

Nanoscale ◽  
2014 ◽  
Vol 6 (22) ◽  
pp. 13451-13456 ◽  
Author(s):  
Adrian Taruttis ◽  
Neus Lozano ◽  
Antonio Nunes ◽  
Dhifaf A. Jasim ◽  
Nicolas Beziere ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Gold Nanorods ◽  
Gold Nanorod ◽  
Vector System ◽  
Optoacoustic Tomography

This study describes the simultaneous in vivo optoacousic imaging and siRNA-mediated gene silencing capabilities of a model theranostic vector system between liposomes and gold nanorods.

scholarly journals Gold nanorod-assembled ZnGa2O4:Cr nanofibers for LED-amplified gene silencing in cancer cells

Nanoscale ◽  
2018 ◽  
Vol 10 (28) ◽  
pp. 13432-13442 ◽  
Author(s):  
Lun Qin ◽  
Peijian Yan ◽  
Congkun Xie ◽  
Jie Huang ◽  
Zhaohui Ren ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Cancer Cells ◽  
Gold Nanorods ◽  
Gold Nanorod ◽  
Photothermal Effect ◽  
Therapeutic System

A localized therapeutic system, consisting of gold nanorods (Au NRs) loaded with hTERT siRNA assembled on the surface of ZnGa2O4:Cr (ZGOC) nanofibers, offers the potential for a LED-induced mild photothermal effect which enhances gene silencing effect in cancer cells.

In vivotumor active cancer targeting and CT-fluorescence dual-modal imaging with nanoprobe based on gold nanorods and InP/ZnS quantum dots

2018 ◽  
Vol 6 (17) ◽  
pp. 2574-2583 ◽  
Author(s):  
Lin Zhang ◽  
Xiao-Quan Yang ◽  
Jie An ◽  
Sun-Duo Zhao ◽  
Tian-Yu Zhao ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Gold Nanorods ◽  
Gold Nanorod ◽  
Active Targeting ◽  
Cancer Targeting ◽  
Multifunctional Nanoprobe ◽  
Active Cancer

Gold nanorod, InP/ZnS QD and c(RGDfC) based multifunctional nanoprobe for dual-modal imaging of active targeting of tumorsin vivo.

Optoacoustic tomography in preclinical research: in vivo distribution of highly purified PEG-coated gold nanorods

2011 ◽  
Author(s):  
Richard Su ◽  
Anton Liopo ◽  
Sergey A. Ermilov ◽  
Hans-Peter Brecht ◽  
Kirill Larin ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Preclinical Research ◽  
Optoacoustic Tomography ◽  
In Vivo Distribution

Optoacoustic tomography in preclinical research: in vivo distribution of highly purified PEG-coated gold nanorods

2011 ◽  
Author(s):  
Richard Su ◽  
Anton Liopo ◽  
Hans-Peter Brecht ◽  
Sergey Ermilov ◽  
Kirill Larin ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Preclinical Research ◽  
Optoacoustic Tomography ◽  
In Vivo Distribution

MicroCT Imaging and In Vivo Temperature Elevations in Implanted Prostatic Tumors in Laser Photothermal Therapy Using Gold Nanorods

2012 ◽  
Vol 3 (2) ◽  
Author(s):  
N. Manuchehrabadi ◽  
A. Attaluri ◽  
H. Cai ◽  
R. Edziah ◽  
E. Lalanne ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Imaging System ◽  
Laser Energy ◽  
Gold Nanorod ◽  
Laser Irradiance ◽  
Theoretical Simulation ◽  
Microct Imaging ◽  
Laser Photothermal Therapy

In this study, in vivo animal experiments are performed on implanted xenograph prostatic tumors in nude mice to investigate enhanced laser energy absorption in the tumors by an intratumoral injection of gold nanorod solutions. In vivo temperature mapping of the tumors during laser photothermal therapy has shown the feasibility of elevating tumor temperatures higher than 50 °C using only 0.1 ml nanorod solution and a low laser irradiance of 1.6 W/cm2 incident on the tumor surface. The temperature profile suggests that normal tumor tissue still absorbs some amount of the laser energy without nanorod presence; however, the injected nanorods ensure that almost all the laser energy is absorbed and confined to the targeted tumors. The inverse relationship between the temperature elevations and the tumor size implies a relatively uniform spreading of the nanorods to the entire tumor, which is also shown by microcomputed tomography (microCT) imaging analyses. The feasibility of detecting 250 OD gold nanorod solution injected to the tumors is demonstrated via a high resolution microCT imaging system. Compared to other nanostructures, the gold nanorods used in this study do not accumulate surrounding the injection site. The relatively uniform deposition of the nanorods in the tumors observed by the microCT scans can be helpful in future study in simplifying theoretical simulation of temperature elevations in tumors during laser photothermal therapy.

Gene Silencing using siRNA for Preventing Liver Ischaemia-Reperfusion Injury

2018 ◽  
Vol 24 (23) ◽  
pp. 2692-2700 ◽  
Author(s):  
H. Susana Marinho ◽  
Paulo Marcelino ◽  
Helena Soares ◽  
Maria Luísa Corvo
Keyword(s):  
Gene Silencing ◽  
Reperfusion Injury ◽  
Therapeutic Potential ◽  
Major Complication ◽  
Ischaemia Reperfusion Injury ◽  
Small Interference Rna ◽  
Ischaemia Reperfusion ◽  
Promising Therapeutic Approach ◽  
Sirna Therapy

Background: Ischaemia-reperfusion injury (IRI), a major complication occurring during organ transplantation, involves an initial ischemia insult, due to loss of blood supply, followed by an inflammation-mediated reperfusion injury. A variety of molecular targets and pathways involved in liver IRI have been identified. Gene silencing through RNA interference (RNAi) by means of small interference RNA (siRNA) targeting mediators of IRI is a promising therapeutic approach. Objective: This study aims at reviewing the use of siRNAs as therapeutic agents to prevent IRI during liver transplantation. Method: We review the crucial choice of siRNA targets and the advantages and problems of the use of siRNAs. Results: We propose possible targets for siRNA therapy during liver IRI. Moreover, we discuss how drug delivery systems, namely liposomes, may improve siRNA therapy by increasing siRNA stability in vivo and avoiding siRNA off-target effects. Conclusion: siRNA therapeutic potential to preclude liver IRI can be improved by a better knowledge of what molecules to target and by using more efficient delivery strategies.

scholarly journals Effective replacement of cetyltrimethylammonium bromide (CTAB) by mercaptoalkanoic acids on gold nanorod (AuNR) surfaces in aqueous solutions

Nanoscale ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 658-668 ◽  
Author(s):  
Rafael del Caño ◽  
Jose M. Gisbert-González ◽  
Jose González-Rodríguez ◽  
Guadalupe Sánchez-Obrero ◽  
Rafael Madueño ◽  
...  
Keyword(s):  
Aqueous Solutions ◽  
Gold Nanorods ◽  
Ligand Exchange ◽  
Cetyltrimethylammonium Bromide ◽  
Gold Nanorod ◽  
Experimental Conditions ◽  
Seed Mediated ◽  
The Stability

The highly packed cetyltrimethylammonium bromide bilayer on the surface of gold nanorods synthesized by the seed-mediated procedure hampers the complete ligand exchange under experimental conditions that preserves the stability of the dispersions.

scholarly journals Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

2012 ◽  
Vol 124 (34) ◽  
pp. 8657-8661 ◽  
Author(s):  
Muthusamy Jayaraman ◽  
Steven M. Ansell ◽  
Barbara L. Mui ◽  
Ying K. Tam ◽  
Jianxin Chen ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Lipid Nanoparticles

scholarly journals In vivo gene silencing following non-invasive siRNA delivery into the skin using a novel topical formulation

2014 ◽  
Vol 196 ◽  
pp. 355-362 ◽  
Author(s):  
Vikas Hegde ◽  
Robyn P. Hickerson ◽  
Sitheswaran Nainamalai ◽  
Paul A. Campbell ◽  
Frances J.D. Smith ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Sirna Delivery ◽  
Topical Formulation ◽  
Non Invasive
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