Main-chain polyacetal conjugates with HIF-1 inhibitors: temperature-responsive, pH-degradable drug delivery vehicles

2018 ◽  
Vol 6 (4) ◽  
pp. 666-674 ◽  
Author(s):  
Sanjoy Samanta ◽  
Chathuranga C. De Silva ◽  
Porakrit Leophairatana ◽  
Jeffrey T. Koberstein
Keyword(s):  
Drug Delivery ◽  
Tumor Tissue ◽  
Main Chain ◽  
Drug Delivery Vehicles ◽  
Temperature Responsive ◽  
Drug Conjugates ◽  
Release Drug ◽  
Delivery Vehicles

Main-chain polyacetal drug conjugates are temperature responsive and pH degradable and can be designed to selectively target, retain and release drug in hyperthermic tumor tissue.

Albumin–Polymer–Drug Conjugates: Long Circulating, High Payload Drug Delivery Vehicles

2016 ◽  
Vol 5 (10) ◽  
pp. 1089-1094 ◽  
Author(s):  
Anton A. A. Smith ◽  
Kaja Zuwala ◽  
Oliver Pilgram ◽  
Karen Singers Johansen ◽  
Martin Tolstrup ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Vehicles ◽  
Drug Conjugates ◽  
Delivery Vehicles ◽  
Polymer Drug Conjugates ◽  
High Payload

scholarly journals HER2-directed antibodies, affibodies and nanobodies as drug-delivery vehicles in breast cancer with a specific focus on radioimmunotherapy and radioimmunoimaging

2020 ◽  
Author(s):  
Betül Altunay ◽  
Agnieszka Morgenroth ◽  
Mohsen Beheshti ◽  
Andreas Vogg ◽  
Nicholas C. L. Wong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Monoclonal Antibodies ◽  
Molecular Imaging ◽  
Antibody Fragments ◽  
Drug Delivery Vehicles ◽  
Tumor Penetration ◽  
Drug Conjugates ◽  
Delivery Vehicles

Abstract Purpose The aim of the present paper is to review the role of HER2 antibodies, affibodies and nanobodies as vehicles for imaging and therapy approaches in breast cancer, including a detailed look at recent clinical data from antibody drug conjugates and nanobodies as well as affibodies that are currently under development. Results Clinical and preclinical studies have shown that the use of monoclonal antibodies in molecular imaging is impaired by slow blood clearance, associated with slow and low tumor uptake and with limited tumor penetration potential. Antibody fragments, such as nanobodies, on the other hand, can be radiolabelled with short-lived radioisotopes and provide high-contrast images within a few hours after injection, allowing early diagnosis and reduced radiation exposure of patients. Even in therapy, the small radioactively labeled nanobodies prove to be superior to radioactively labeled monoclonal antibodies due to their higher specificity and their ability to penetrate the tumor. Conclusion While monoclonal antibodies are well established drug delivery vehicles, the current literature on molecular imaging supports the notion that antibody fragments, such as affibodies or nanobodies, might be superior in this approach.

Filamentous supramolecular peptide–drug conjugates as highly efficient drug delivery vehicles

2014 ◽  
Vol 50 (37) ◽  
pp. 4827-4830 ◽  
Author(s):  
Miao Yang ◽  
Dawei Xu ◽  
Linhai Jiang ◽  
Lin Zhang ◽  
Derek Dustin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Carrier ◽  
Drug Efficacy ◽  
Cancer Drug ◽  
Peptide Drug ◽  
Drug Delivery Vehicles ◽  
Drug Conjugates ◽  
Anti Cancer ◽  
Delivery Vehicles ◽  
Peptide Drug Conjugates

We report here a facile approach to prepare filamentous supramolecular peptide–drug conjugates with precise drug/carrier stoichiometry, nearly 100% loading efficiency and exceptional anti-cancer drug efficacy for chemotherapy.

Nano-Imprint Fabrication of Injectable, Stimuli-Responsive Drug Delivery Vehicles

2005 ◽  
Author(s):  
Luz Cristal S. Glangchai ◽  
Li Shi ◽  
Krishnendu Roy
Keyword(s):  
Drug Delivery ◽  
Physiological Signals ◽  
Stimuli Responsive ◽  
Drug Delivery Vehicles ◽  
Nano Fabrication ◽  
Release Drug ◽  
Delivery Vehicles ◽  
Stimuli Responsive Polymer ◽  
Drug Delivery Devices ◽  
Nano Imprint

Nanofabrication techniques are developed to create well-defined and characterized drug delivery devices that overcome the limitations of current methods. Our approach is to use novel, top-down nano-fabrication technologies, including thermal nano-imprinting and step-and flash imprint lithography (S-FIL), coupled with stimuli-responsive polymer membranes to develop injectable nanocontainers that can release drug only in response to specific physiological signals at specific cellular locations.

Dendrimers: General Aspects, Applications and Structural Exploitations as Prodrug/Drug-delivery Vehicles in Current Medicine

2018 ◽  
Vol 18 (5) ◽  
pp. 439-457 ◽  
Author(s):  
Merina Mariyam ◽  
Kajal Ghosal ◽  
Sabu Thomas ◽  
Nandakumar Kalarikkal ◽  
Mahima S. Latha
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
General Aspects

Novel Phospholipid-Based Labrasol Nanomicelles Loaded Flavonoids for Oral Delivery with Enhanced Penetration and Anti-Brain Tumor Efficiency

2020 ◽  
Vol 17 (3) ◽  
pp. 229-245
Author(s):  
Gang Wang ◽  
Junjie Wang ◽  
Rui Guan
Keyword(s):  
Drug Delivery ◽  
Brain Tumor ◽  
Oral Delivery ◽  
Safe Delivery ◽  
Drug Delivery Vehicles ◽  
Therapeutic Benefits ◽  
Delivery Vehicles ◽  
The Brain

Background: Owing to the rich anticancer properties of flavonoids, there is a need for their incorporation into drug delivery vehicles like nanomicelles for safe delivery of the drug into the brain tumor microenvironment. Objective: This study, therefore, aimed to prepare the phospholipid-based Labrasol/Pluronic F68 modified nano micelles loaded with flavonoids (Nano-flavonoids) for the delivery of the drug to the target brain tumor. Methods: Myricetin, quercetin and fisetin were selected as the initial drugs to evaluate the biodistribution and acute toxicity of the drug delivery vehicles in rats with implanted C6 glioma tumors after oral administration, while the uptake, retention, release in human intestinal Caco-2 cells and the effect on the brain endothelial barrier were investigated in Human Brain Microvascular Endothelial Cells (HBMECs). Results: The results demonstrated that nano-flavonoids loaded with myricetin showed more evenly distributed targeting tissues and enhanced anti-tumor efficiency in vivo without significant cytotoxicity to Caco-2 cells and alteration in the Trans Epithelial Electric Resistance (TEER). There was no pathological evidence of renal, hepatic or other organs dysfunction after the administration of nanoflavonoids, which showed no significant influence on cytotoxicity to Caco-2 cells. Conclusion: In conclusion, Labrasol/F68-NMs loaded with MYR and quercetin could enhance antiglioma effect in vitro and in vivo, which may be better tools for medical therapy, while the pharmacokinetics and pharmacodynamics of nano-flavonoids may ensure optimal therapeutic benefits.

scholarly journals Biodistribution and Pharmacokinectics of Liposomes and Exosomes in a Mouse Model of Sepsis

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 427
Author(s):  
Amin Mirzaaghasi ◽  
Yunho Han ◽  
So-Hee Ahn ◽  
Chulhee Choi ◽  
Ji-Ho Park
Keyword(s):  
Drug Delivery ◽  
Therapeutic Potential ◽  
Hek293t Cell ◽  
Biological Properties ◽  
Context Analysis ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Diseased State ◽  
Sepsis And Septic Shock

Exosomes have attracted considerable attention as drug delivery vehicles because their biological properties can be utilized for selective delivery of therapeutic cargoes to disease sites. In this context, analysis of the in vivo behaviors of exosomes in a diseased state is required to maximize their therapeutic potential as drug delivery vehicles. In this study, we investigated biodistribution and pharmacokinetics of HEK293T cell-derived exosomes and PEGylated liposomes, their synthetic counterparts, into healthy and sepsis mice. We found that biodistribution and pharmacokinetics of exosomes were significantly affected by pathophysiological conditions of sepsis compared to those of liposomes. In the sepsis mice, a substantial number of exosomes were found in the lung after intravenous injection, and their prolonged blood residence was observed due to the liver dysfunction. However, liposomes did not show such sepsis-specific effects significantly. These results demonstrate that exosome-based therapeutics can be developed to manage sepsis and septic shock by virtue of their sepsis-specific in vivo behaviors.

scholarly journals Advances in Molecularly Imprinted Polymers as Drug Delivery Systems

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3589
Author(s):  
Rui Liu ◽  
Alessandro Poma
Keyword(s):  
Drug Delivery ◽  
Molecularly Imprinted Polymers ◽  
Drug Loading ◽  
Stimuli Responsive ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Drug Delivery Vehicles ◽  
The Past ◽  
Drug Molecules ◽  
Delivery Vehicles

Despite the tremendous efforts made in the past decades, severe side/toxic effects and poor bioavailability still represent the main challenges that hinder the clinical translation of drug molecules. This has turned the attention of investigators towards drug delivery vehicles that provide a localized and controlled drug delivery. Molecularly imprinted polymers (MIPs) as novel and versatile drug delivery vehicles have been widely studied in recent years due to the advantages of selective recognition, enhanced drug loading, sustained release, and robustness in harsh conditions. This review highlights the design and development of strategies undertaken for MIPs used as drug delivery vehicles involving different drug delivery mechanisms, such as rate-programmed, stimuli-responsive and active targeting, published during the course of the past five years.

scholarly journals A Review on Allopathic and Herbal Nanofibrous Drug Delivery Vehicles for Cancer Treatments

2021 ◽  
pp. e00663
Author(s):  
Tarun Mateti ◽  
Surabhi Aswath ◽  
Anoop Kishore Vatti ◽  
Agneya Kamath ◽  
Anindita Laha
Keyword(s):  
Drug Delivery ◽  
Cancer Treatments ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles
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