Facile synthesis of red-emitting carbon dots from pulp-free lemon juice for bioimaging

2017 ◽  
Vol 5 (26) ◽  
pp. 5272-5277 ◽  
Author(s):  
Hui Ding ◽  
Yuan Ji ◽  
Ji-Shi Wei ◽  
Qing-Yu Gao ◽  
Zi-Yuan Zhou ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Lemon Juice ◽  
Facile Synthesis

A facile method was developed to produce efficient red-emitting carbon dots from pulp-free lemon juice for bioimaging both in vitro and in vivo.

Facile synthesis of a highly luminescent carbon dot@silica nanorattle for in vivo bioimaging

RSC Advances ◽  
2015 ◽  
Vol 5 (57) ◽  
pp. 46158-46162 ◽  
Author(s):  
Changhui Fu ◽  
Li Qiang ◽  
Qinghua Liang ◽  
Xue Chen ◽  
Linlin Li ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Facile Synthesis ◽  
Carbon Dot ◽  
Silica Nanorattle

Carbon dots embedded in silica nanorattle (CDs@SN) nanocomposites with high luminescence are synthesized and exhibit brighter fluorescence in vitro and in vivo than CDs alone.

Carbon dots derived from Fusobacterium nucleatum for intracellular determination of Fe3+ and bioimaging both in vitro and in vivo

2021 ◽  
Author(s):  
Lijuan Liu ◽  
Shengting Zhang ◽  
Xiaodan Zheng ◽  
Hongmei Li ◽  
Qi Chen ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Fusobacterium Nucleatum ◽  
Living Cells ◽  
First Time ◽  
Fluorescent Carbon Dots ◽  
Fluorescent Carbon

Fusobacterium nucleatum has been employed for the first time to synthesize fluorescent carbon dots which could be applied for the determination of Fe3+ ions in living cells and bioimaging in vitro and in vivo with excellent biocompatibility.

scholarly journals Combined In Vitro and In Vivo Approaches to Propose a Putative Adverse Outcome Pathway for Acute Lung Inflammation Induced by Nanoparticles: A Study on Carbon Dots

Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 180
Author(s):  
Maud Weiss ◽  
Jiahui Fan ◽  
Mickaël Claudel ◽  
Luc Lebeau ◽  
Françoise Pons ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Lung Inflammation ◽  
Adverse Outcome ◽  
Cellular Responses ◽  
Target Cells ◽  
Inflammasome Activation ◽  
Adverse Outcome Pathway ◽  
Acute Lung Inflammation

With the growth of nanotechnologies, concerns raised regarding the potential adverse effects of nanoparticles (NPs), especially on the respiratory tract. Adverse outcome pathways (AOP) have become recently the subject of intensive studies in order to get a better understanding of the mechanisms of NP toxicity, and hence hopefully predict the health risks associated with NP exposure. Herein, we propose a putative AOP for the lung toxicity of NPs using emerging nanomaterials called carbon dots (CDs), and in vivo and in vitro experimental approaches. We first investigated the effect of a single administration of CDs on mouse airways. We showed that CDs induce an acute lung inflammation and identified airway macrophages as target cells of CDs. Then, we studied the cellular responses induced by CDs in an in vitro model of macrophages. We observed that CDs are internalized by these cells (molecular initial event) and induce a series of key events, including loss of lysosomal integrity and mitochondrial disruption (organelle responses), as well as oxidative stress, inflammasome activation, inflammatory cytokine upregulation and macrophage death (cellular responses). All these effects triggering lung inflammation as tissular response may lead to acute lung injury.

scholarly journals Exploring heteroaromatic rings as a replacement for the labile amide of antiplasmodial pantothenamides

2020 ◽  
Author(s):  
Jinming Guan ◽  
Christina Spry ◽  
Erick T. Tjhin ◽  
Penghui Yang ◽  
Tanakorn Kittikool ◽  
...  
Keyword(s):  
Contact Time ◽  
High Selectivity ◽  
Amide Group ◽  
Antiplasmodial Activity ◽  
Time Data ◽  
Facile Synthesis ◽  
Isoxazole Derivative ◽  
Nanomolar Range

ABSTRACTThe Plasmodium parasites that cause malaria are adept at developing resistance to antimalarial drugs, necessitating the search for new antiplasmodials. Although several amide analogs of pantothenate (pantothenamides) show potent antiplasmodial activity, hydrolysis by pantetheinases (or vanins) present in blood rapidly inactivates them. We report herein the facile synthesis and biological activity of a small library of pantothenamide analogs in which the labile amide group is replaced with a variety of heteroaromatic rings. Several of the new analogs display antiplasmodial activity in the nanomolar range against P. falciparum and/or P. knowlesi in the presence of pantetheinase. A previously reported triazole and an isoxazole derivative presented here were further characterized and found to possess high selectivity indices, medium or high Caco-2 permeability, and medium or low microsomal clearance in vitro. Although we show here that the two compounds fail to suppress proliferation of P. berghei in vivo, pharmacokinetic and contact time data presented provide a benchmark for the compound profile required to achieve antiplasmodial activity in mice and should facilitate lead optimization.

Lysosome-targeted red-fluorescent carbon dots for turn-on detection of permanganate and pH in vivo and in vitro

2021 ◽  
pp. 130774
Author(s):  
Dan Chang ◽  
Zhonghua Zhao ◽  
Jianyang Feng ◽  
Yuye Xin ◽  
Yongxing Yang ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Turn On ◽  
Fluorescent Carbon Dots ◽  
Fluorescent Carbon

In situ synthesis of NIR-light emitting carbon dots derived from spinach for bio-imaging applications

2017 ◽  
Vol 5 (35) ◽  
pp. 7328-7334 ◽  
Author(s):  
Liping Li ◽  
Ruiping Zhang ◽  
Chunxiang Lu ◽  
Jinghua Sun ◽  
Lingjie Wang ◽  
...  
Keyword(s):  
Optical Properties ◽  
Carbon Dots ◽  
In Situ Synthesis ◽  
Light Emitting ◽  
Nir Light ◽  
Bio Imaging ◽  
One Step

NIR-light emitting CDs (R-CDs) were prepared using spinach as a precursor by one-step solvothermal treatment. The R-CDs exhibited great optical properties, negligible toxicity, and superior labelling capability both in vitro and in vivo.

Low temperature synthesis of phosphorous and nitrogen co-doped yellow fluorescent carbon dots for sensing and bioimaging

2015 ◽  
Vol 3 (33) ◽  
pp. 6813-6819 ◽  
Author(s):  
Xiaojuan Gong ◽  
Wenjing Lu ◽  
Yang Liu ◽  
Zengbo Li ◽  
Shaomin Shuang ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Ph Sensing ◽  
Low Temperature Synthesis ◽  
Low Toxicity ◽  
Doped Carbon Dots ◽  
Fluorescent Carbon Dots ◽  
Co Doped ◽  
High Output

A simple and high-output strategy for the fabrication of yellow fluorescent phosphorous and nitrogen co-doped carbon dots (P,N-CDs) is developed. P,N-CDs possess distinctive photoluminescence properties, low toxicity, and biocompatible. P,N-CDs are potentially useful for versatile applications such as pH sensing, in vitro and in vivo imaging.

Fluorescent carbon dots from antineoplastic drug etoposide for bioimaging in vitro and in vivo

2017 ◽  
Vol 5 (38) ◽  
pp. 7796-7800 ◽  
Author(s):  
Bin Wu ◽  
Rongrong Zhu ◽  
Mei Wang ◽  
Peng Liang ◽  
Yechang Qian ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Antineoplastic Drug ◽  
Step Method ◽  
One Step ◽  
Fluorescent Carbon Dots ◽  
Fluorescent Carbon

Carbon dots for bioimaging in vitro and in vivo were synthesized from the antineoplastic drug etoposide by a one-step method.

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