Effects of HAp and TCP in constructing tissue engineering scaffolds for bone repair

2017 ◽  
Vol 5 (30) ◽  
pp. 6110-6118 ◽  
Author(s):  
Sijia Xu ◽  
Jianheng Liu ◽  
Licheng Zhang ◽  
Fei Yang ◽  
Peifu Tang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Repair ◽  
Tissue Engineering Scaffold ◽  
Long Term Effects ◽  
Tissue Engineering Scaffolds ◽  
Early Repair

TCP possesses superior long-term effects in structuring tissue engineering scaffold for bone repair compared to HAp, though TCP lags behind HAp in the early repair period.

Tissue Engineering Scaffolds for Bone Repair: General Aspects

2016 ◽  
pp. 269-285 ◽  
Author(s):  
Andrés Díaz Lantada ◽  
Adrián de Blas Romero ◽  
Santiago Valido Moreno ◽  
Diego Curras ◽  
Miguel Téllez ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Repair ◽  
Tissue Engineering Scaffolds ◽  
General Aspects

scholarly journals Fibrin Gel as an Injectable Biodegradable Scaffold and Cell Carrier for Tissue Engineering

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Yuting Li ◽  
Hao Meng ◽  
Yuan Liu ◽  
Bruce P. Lee
Keyword(s):  
Tissue Engineering ◽  
Cell Attachment ◽  
Polymer Network ◽  
Tissue Engineering Scaffold ◽  
Fibrin Gel ◽  
Tissue Engineering Scaffolds ◽  
Injectable Scaffolds ◽  
Synthetic Materials ◽  
Cell Carrier ◽  
A Cell

Due to the increasing needs for organ transplantation and a universal shortage of donated tissues, tissue engineering emerges as a useful approach to engineer functional tissues. Although different synthetic materials have been used to fabricate tissue engineering scaffolds, they have many limitations such as the biocompatibility concerns, the inability to support cell attachment, and undesirable degradation rate. Fibrin gel, a biopolymeric material, provides numerous advantages over synthetic materials in functioning as a tissue engineering scaffold and a cell carrier. Fibrin gel exhibits excellent biocompatibility, promotes cell attachment, and can degrade in a controllable manner. Additionally, fibrin gel mimics the natural blood-clotting process and self-assembles into a polymer network. The ability for fibrin to curein situhas been exploited to develop injectable scaffolds for the repair of damaged cardiac and cartilage tissues. Additionally, fibrin gel has been utilized as a cell carrier to protect cells from the forces during the application and cell delivery processes while enhancing the cell viability and tissue regeneration. Here, we review the recent advancement in developing fibrin-based biomaterials for the development of injectable tissue engineering scaffold and cell carriers.

scholarly journals A Nanofiber Mat With Dual Bioactive Components and a Biomimetic Matrix Structure for Improving Osteogenesis Effect

2021 ◽  
Vol 9 ◽  
Author(s):  
Yadi Han ◽  
Xiaofeng Shen ◽  
Sihao Chen ◽  
Xiuhui Wang ◽  
Juan Du ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Bone Repair ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Bioactive Components ◽  
Tissue Engineering Scaffolds ◽  
Cell Growth And Migration ◽  
Nanofiber Mats

The challenge of effectively regenerating bone tissue through tissue engineering technology is that most tissue engineering scaffolds cannot imitate the three-dimensional structure and function of the natural extracellular matrix. Herein, we have prepared the poly(L-lactic acid)–based dual bioactive component reinforced nanofiber mats which were named as poly(L-lactic acid)/bovine serum albumin/nanohydroxyapatite (PLLA/BSA/nHAp) with dual bioactive components by combining homogeneous blending and electrospinning technology. The results showed that these nanofiber mats had sufficient mechanical properties and a porous structure suitable for cell growth and migration. Furthermore, the results of cell experiments in vitro showed that PLLA/BSA/nHAp composite nanofiber mat could preferably stimulate the proliferation of mouse osteoblastic cells (MC3T3 cells) compared with pure PLLA nanofiber mats. Based on these results, the scaffolds developed in this study are considered to have a great potential to be adhibited as bone repair materials.

scholarly journals An in situ tissue engineering scaffold with growth factors combining angiogenesis and osteoimmunomodulatory functions for advanced periodontal bone regeneration

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Tian Ding ◽  
Wenyan Kang ◽  
Jianhua Li ◽  
Lu Yu ◽  
Shaohua Ge
Keyword(s):  
Tissue Engineering ◽  
Growth Factors ◽  
Bone Regeneration ◽  
Bone Defect ◽  
Bone Repair ◽  
Macrophage Polarization ◽  
Tissue Engineering Scaffold ◽  
Bone Morphogenetic Protein 2 ◽  
In Situ Tissue Engineering

Abstract Background The regeneration of periodontal bone defect remains a vital clinical challenge. To date, numerous biomaterials have been applied in this field. However, the immune response and vascularity in defect areas may be key factors that are overlooked when assessing the bone regeneration outcomes of biomaterials. Among various regenerative therapies, the up-to-date strategy of in situ tissue engineering stands out, which combined scaffold with specific growth factors that could mimic endogenous regenerative processes. Results Herein, we fabricated a core/shell fibrous scaffold releasing basic fibroblast growth factor (bFGF) and bone morphogenetic protein-2 (BMP-2) in a sequential manner and investigated its immunomodulatory and angiogenic properties during periodontal bone defect restoration. The in situ tissue engineering scaffold (iTE-scaffold) effectively promoted the angiogenesis of periodontal ligament stem cells (PDLSCs) and induced macrophage polarization into pro-healing M2 phenotype to modulate inflammation. The immunomodulatory effect of macrophages could further promote osteogenic differentiation of PDLSCs in vitro. After being implanted into the periodontal bone defect model, the iTE-scaffold presented an anti-inflammatory response, provided adequate blood supply, and eventually facilitated satisfactory periodontal bone regeneration. Conclusions Our results suggested that the iTE-scaffold exerted admirable effects on periodontal bone repair by modulating osteoimmune environment and angiogenic activity. This multifunctional scaffold holds considerable promise for periodontal regenerative medicine and offers guidance on designing functional biomaterials. Graphic Abstract

Electrospun multicomponent and multifunctional nanofibrous bone tissue engineering scaffolds

2017 ◽  
Vol 5 (7) ◽  
pp. 1388-1399 ◽  
Author(s):  
Chong Wang ◽  
Min Wang
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tissue Engineering Scaffold ◽  
Tissue Engineering Scaffolds ◽  
Dual Power

A tricomponent bone tissue engineering scaffold incorporating rhVEGF, rhBMP-2 and Ca-P was made through multi-source dual-power electrospinning.

Preparation and characterization of alginate/HACC/oyster shell powder biocomposite scaffolds for potential bone tissue engineering applications

RSC Advances ◽  
2016 ◽  
Vol 6 (42) ◽  
pp. 35577-35588 ◽  
Author(s):  
Tai-ying Chen ◽  
Hao-chao Huang ◽  
Jia-lin Cao ◽  
Yan-jiao Xin ◽  
Wen-feng Luo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Repair ◽  
Oyster Shell ◽  
Natural Polymers ◽  
Tissue Engineering Scaffolds ◽  
Repair Materials ◽  
Oyster Shell Powder ◽  
Bone Repair Materials ◽  
Shell Powder

Tissue engineering scaffolds combining biominerals and natural polymers are prospective candidates for bone repair materials.

scholarly journals A Systematic Review of Tissue Engineering Scaffold in Tendon Bone Healing in vivo

2021 ◽  
Vol 9 ◽  
Author(s):  
Zimu Mao ◽  
Baoshi Fan ◽  
Xinjie Wang ◽  
Ximeng Huang ◽  
Jian Guan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Healing ◽  
Animal Studies ◽  
Ligament Reconstruction ◽  
Search Strategy ◽  
Web Of Science ◽  
Tissue Engineering Scaffold ◽  
Tissue Engineering Scaffolds ◽  
Eligibility Criteria

Background: Tendon-bone healing is an important factor in determining the success of ligament reconstruction. With the development of biomaterials science, the tissue engineering scaffold plays an extremely important role in tendon-bone healing and bone tissue engineering.Materials and Methods: Electronic databases (PubMed, Embase, and the Web of Science) were systematically searched for relevant and qualitative studies published from 1 January 1990 to 31 December 2019. Only original articles that met eligibility criteria and evaluated the use of issue engineering scaffold especially biomaterials in tendon bone healing in vivo were selected for analysis.Results: The search strategy identified 506 articles, and 27 studies were included for full review including two human trials and 25 animal studies. Fifteen studies only used biomaterials like PLGA, collage, PCL, PLA, and PET as scaffolds to repair the tendon-bone defect, on this basis, the rest of the 11 studies using biological interventions like cells or cell factors to enhance the healing. The adverse events hardly ever occurred, and the tendon bone healing with tissue engineering scaffold was effective and superior, which could be enhanced by biological interventions.Conclusion: Although a number of tissue engineering scaffolds have been developed and applied in tendon bone healing, the researches are mainly focused on animal models which are with limitations in clinical application. Since the efficacy and safety of tissue engineering scaffold has been proved, and can be enhanced by biological interventions, substantial clinical trials remain to be done, continued progress in overcoming current tissue engineering challenges should allow for successful clinical practice.

Sign in / Sign up

Export Citation Format

Share Document