Long-term effects of porcine small intestine submucosa on the healing of medial collateral ligament: A functional tissue engineering study

2006 ◽  
Vol 24 (4) ◽  
pp. 811-819 ◽  
Author(s):  
Rui Liang ◽  
Savio L.-Y. Woo ◽  
Yoshiyuki Takakura ◽  
Daniel K. Moon ◽  
Fengyan Jia ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Small Intestine ◽  
Medial Collateral Ligament ◽  
Small Intestine Submucosa ◽  
Long Term Effects ◽  
Collateral Ligament ◽  
Functional Tissue Engineering ◽  
Engineering Study ◽  
Porcine Small Intestine Submucosa

Characterization of αGal(−) ECM Bioscaffolds: An Indication for Application in Tissue Engineering

2011 ◽  
Author(s):  
Rui Liang ◽  
Matthew B. Fisher ◽  
Guoguang Yang ◽  
Christine Hall ◽  
Savio L-Y. Woo
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Small Intestine ◽  
Animal Models ◽  
Urinary Bladder ◽  
Biomechanical Properties ◽  
Small Intestine Submucosa ◽  
Urinary Bladder Matrix ◽  
Porcine Small Intestine Submucosa

Extracellular matrix (ECM) bioscaffolds derived from animal sources, such as porcine small intestine submucosa (SIS) and urinary bladder matrix (UBM), have a successful history for application in clinical and/or experimental settings [1]. In our research center, we have demonstrated that the porcine SIS bioscaffolds could improve the morphological, biochemical, and biomechanical properties of healing ligaments and tendons in different animal models [2, 3].

scholarly journals Lichtenstein inguinal hernia repairs with porcine small intestine submucosa: a 5- year follow-up. a prospective randomized controlled study

2021 ◽  
Author(s):  
Baoshan Li ◽  
Xin Zhang ◽  
Yi Man ◽  
Jiadong Xie ◽  
Wei Hu ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Inguinal Hernia ◽  
Hernia Repair ◽  
Term Effect ◽  
Control Group ◽  
Small Intestine Submucosa ◽  
Long Term Effect ◽  
Porcine Small Intestine Submucosa

Abstract Porcine small intestine submucosa (SIS) biologic patch has been used in inguinal hernia repair. However, there are little data available to assess the long-term effect after repair. This study aimed to explore the long-term effect of SIS patch in open inguinal hernia repair. Sevent-six patients with unilateral inguinal hernia were treated with Lichtenstein tension-free hernia repair using SIS patch (Beijing Datsing Bio-Tech Co., Ltd.) and Surgisis patch (COOK, USA) in Tianjin Union Medical Center and China-Japan Friendship Hospital. In the trial, the long-term efficacy of the treatment group and the control group were compared. A total of 66 patients in both groups received long-term follow-up (> 5 years) after surgery, with a follow-up rate of 86.8%. During the follow-up period, there was one case of recurrence, one case of chronic pain in the control group. There was no statistically significant difference (P > 0.05) in terms of recurrence, chronic pain, foreign body sensation and infection between the two groups of patients. After long-term observations, it has been found that the porcine small intestinal submucosa (SIS) biological patch is safe and effective for inguinal hernia Lichtenstein repair, and has a low recurrence rate and complication rate.

A Paradigm for Functional Tissue Engineering

2000 ◽  
Author(s):  
David L. Butler
Keyword(s):  
Tissue Engineering ◽  
Tendon Repair ◽  
National Committee ◽  
New Paradigm ◽  
Functional Tissue Engineering ◽  
Functional Tissue ◽  
Tissue Engineer ◽  
Surgical Implants ◽  
The Us

Abstract Clinicians, biologists, and engineers face difficult challenges in engineering effective, cell-based composites for repair of orthopaedic and cardiovascular tissues. Whether repairing articular cartilage, bone, or blood vessel, the demands placed on the surgical implants can threaten the long-term success of the procedure. In 1998, the US National Committee on Biomechanics addressed this problem by suggesting a new paradigm for tissue engineering called “functional tissue engineering” or FTE. FTE seeks to address several important questions. What are the biomechanical demands placed upon the normal tissue and hence the tissue engineered implant after surgery? What parameters should a tissue engineer design into the implant before surgery? And what biomechanical parameters should the tissue engineer track to determine if the resulting repair is successful? To illustrate the principles, this presentation will discuss tendon repair as a model system for functional tissue engineering.

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