The improved sensitive detection of C-reactive protein based on the chemiluminescence immunoassay by employing monodispersed PAA-Au/Fe3O4 nanoparticles and zwitterionic glycerophosphoryl choline

2017 ◽  
Vol 5 (21) ◽  
pp. 3919-3926 ◽  
Author(s):  
Yan Xing ◽  
Qin Gao ◽  
Yanmin Zhang ◽  
Le Ma ◽  
Kang Yong Loh ◽  
...  
Keyword(s):  
Fe3o4 Nanoparticles ◽  
Blocking Agent ◽  
Sensitive Detection ◽  
C Reactive Protein ◽  
Chemiluminescence Immunoassay ◽  
Reactive Protein ◽  
Highly Sensitive

Monodispersed PAA-Au/Fe3O4 NPs were engineered for highly sensitive CRP assay with zwitterionic glycerophosphoryl choline as the co-blocking agent.

One-step kinetics-based immunoassay for the highly sensitive detection of C-reactive protein in less than 30min

2014 ◽  
Vol 456 ◽  
pp. 32-37 ◽  
Author(s):  
Sandeep Kumar Vashist ◽  
Gregor Czilwik ◽  
Thomas van Oordt ◽  
Felix von Stetten ◽  
Roland Zengerle ◽  
...  
Keyword(s):  
Sensitive Detection ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Highly Sensitive ◽  
One Step ◽  
Highly Sensitive Detection

Synthesis of grafted phosphorylcholine polymer layers as specific recognition ligands for C-reactive protein focused on grafting density and thickness to achieve highly sensitive detection

2015 ◽  
Vol 17 (15) ◽  
pp. 9951-9958 ◽  
Author(s):  
Yuri Kamon ◽  
Yukiya Kitayama ◽  
Akiko N. Itakura ◽  
Kyoko Fukazawa ◽  
Kazuhiko Ishihara ◽  
...  
Keyword(s):  
Layer Thickness ◽  
Thin Layers ◽  
Sensitive Detection ◽  
C Reactive Protein ◽  
Polymer Layers ◽  
Reactive Protein ◽  
Specific Recognition ◽  
Grafting Density ◽  
Highly Sensitive ◽  
Highly Sensitive Detection

We studied the effects of layer thickness and grafting density of poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) thin layers as specific ligands for the highly sensitive binding of C-reactive protein (CRP).

Highly sensitive detection of C-reactive protein using a novel dissolution approach in a dye-doped silica nanoparticle-based fluorescence immunoassay

2017 ◽  
Vol 9 (6) ◽  
pp. 994-1003 ◽  
Author(s):  
Robert Nooney ◽  
Valerie Rebello ◽  
Gemma Keegan ◽  
Claire L. O'Connell ◽  
Daragh Byrne ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Silica Nanoparticle ◽  
Sensitive Detection ◽  
Fluorescence Immunoassay ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Enhanced Sensitivity ◽  
Disease Marker ◽  
Highly Sensitive ◽  
Highly Sensitive Detection

A novel dissolution approach was used to achieve enhanced sensitivity in a nanoparticle (NP) immunoassay for the detection of a cardiovascular disease marker, C-reactive protein (CRP).

Fluorogenic nanocrystals for highly sensitive detection of C-reactive protein

2006 ◽  
Vol 153 (3) ◽  
pp. 54 ◽  
Author(s):  
K.-K. Sin ◽  
C.P.-Y. Chan ◽  
W.-M. Leung ◽  
M. Seydack ◽  
R. Renneberg
Keyword(s):  
Sensitive Detection ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Highly Sensitive ◽  
Highly Sensitive Detection

A plasmonic chip-based bio/chemical hybrid sensing system for the highly sensitive detection of C-reactive protein

2016 ◽  
Vol 52 (20) ◽  
pp. 3883-3886 ◽  
Author(s):  
Ryo Matsuura ◽  
Keiko Tawa ◽  
Yukiya Kitayama ◽  
Toshifumi Takeuchi
Keyword(s):  
Surface Plasmon ◽  
Synthetic Polymer ◽  
Sensitive Detection ◽  
C Reactive Protein ◽  
Enhanced Fluorescence ◽  
Reactive Protein ◽  
Sensing System ◽  
Highly Sensitive ◽  
Highly Sensitive Detection ◽  
Polymer Ligand

A synthetic polymer ligand-grafted plasmonic chip was fabricated and demonstrated a highly sensitive detection of C-reactive protein (CRP) by grating-coupled surface plasmon field-enhanced fluorescence.

Wash-free highly sensitive detection of C-reactive protein using gold derivatised triangular silver nanoplates

RSC Advances ◽  
2014 ◽  
Vol 4 (55) ◽  
pp. 29022-29031 ◽  
Author(s):  
Yi Zhang ◽  
Denise E. Charles ◽  
Deirdre M. Ledwith ◽  
Damian Aherne ◽  
Stephen Cunningham ◽  
...  
Keyword(s):  
Sensitive Detection ◽  
C Reactive Protein ◽  
Silver Nanoplates ◽  
Reactive Protein ◽  
Highly Sensitive ◽  
Triangular Silver Nanoplates ◽  
Highly Sensitive Detection

Rapid, wash-free highly sensitive detection of C-reactive protein is reported using nanoplate biosensor sols.

scholarly journals A rapid one-step kinetics-based immunoassay procedure for the highly-sensitive detection of C-reactive protein

2014 ◽  
Author(s):  
Sandeep Kumar Vashist ◽  
Sandeep Kumar Vashist ◽  
Gregor Czilwik ◽  
Thomas van Oordt ◽  
Felix von Stetten ◽  
...  
Keyword(s):  
Sensitive Detection ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Highly Sensitive ◽  
One Step ◽  
Highly Sensitive Detection

scholarly journals The role of systemic inflammation in heart failure

2021 ◽  
Vol 102 (4) ◽  
pp. 510-517
Author(s):  
E V Khazova ◽  
O V Bulashova
Keyword(s):  
Heart Failure ◽  
Cardiovascular Diseases ◽  
Systemic Inflammation ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
C Reactive Protein ◽  
Ventricular Ejection Fraction ◽  
Reactive Protein ◽  
Highly Sensitive

The discussion continues about the role of systemic inflammation in the pathogenesis of cardiovascular diseases of ischemic etiology. This article reviews the information on the role of C-reactive protein in patients with atherosclerosis and heart failure in risk stratification for adverse cardiovascular events, including assessment of factors affecting the basal level of highly sensitive C-reactive protein. Research data (MRFIT, MONICA) have demonstrated a relationship between an increased level of C-reactive protein and the development of coronary heart disease. An increase in the serum level of highly sensitive C-reactive protein is observed in arterial hypertension, dyslipidemia, type 2 diabetes mellitus and insulin resistance, which indicates the involvement of systemic inflammation in these disorders. Currently, the assessment of highly sensitive C-reactive protein is used to determine the risk of developing myocardial infarction and stroke. It has been proven that heart failure patients have a high level of highly sensitive C-reactive protein compared with patients without heart failure. The level of C-reactive protein is referred to as modifiable risk factors for cardiovascular diseases of ischemic origin, since lifestyle changes or taking drugs such as statins, non-steroidal anti-inflammatory drugs, glucocorticoids, etc. reduce the level of highly sensitive C-reactive protein. In patients with heart failure with different left ventricular ejection fraction values, it was found that the regression of the inflammatory response is accompanied by an improvement in prognosis, which confirms the hypothesis of inflammation as a response to stress, which has negative consequences for the cardiovascular system.

Highly sensitive C-reactive protein levels in Iranian patients with pulmonary complication of sulfur mustard poisoning and its correlation with severity of airway diseases

2009 ◽  
Vol 28 (12) ◽  
pp. 739-745 ◽  
Author(s):  
Davood Attaran ◽  
Shahrzad M Lari ◽  
Mohammad Khajehdaluee ◽  
Hossein Ayatollahi ◽  
Mohammad Towhidi ◽  
...  
Keyword(s):  
Lung Function ◽  
Sulfur Mustard ◽  
Chronic Obstructive ◽  
Case Group ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Highly Sensitive ◽  
The Mean ◽  
Hs Crp

Background: Sulfur mustard (SM) is a chemical warfare agent that can cause serious pulmonary complications. This study was designed to determine serum highly sensitive C-reactive protein (hs-CRP) and evaluate its correlation with lung function parameters in patients with chronic obstructive pulmonary disease (COPD) due to SM poisoning. Methods: Fifty consecutive SM patients with stable COPD and a mean age 46.3 ± 9.18 years were enrolled in this cross sectional study. Thirty healthy men were selected as controls. Lung function parameters were evaluated. Serum hs-CRP by immunoturbidometry assay was measured in both the patients and controls. Results: In the case group, the mean forced expiratory volume in one second (FEV1) was 2.14 ± 0.76 L (58.98% ± 17.51% predicted). The mean serum hs-CRP was 9.4 ± 6.78 SD and 3.9 ± 1.92 SD mg/L in the cases and controls, respectively, with significant statistical differences (p < .001). There was negative correlation between the serum hs-CRP and FEV1 levels (p = .01). The serum hs-CRP levels were also correlated with Global Initiative for Chronic Obstructive Lung disease (GOLD) stages (r = .45, p < .001). Conclusions: Our findings suggest that the serum hs-CRP level is increased in SM patients with COPD and may have a direct correlation with disease severity. It may then be used as a marker for the severity of COPD in patients with SM poisoning.

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