Dual-responsive core-crosslinked polyphosphoester-based nanoparticles for pH/redox-triggered anticancer drug delivery

2017 ◽  
Vol 5 (20) ◽  
pp. 3771-3782 ◽  
Author(s):  
Yue Sun ◽  
Xueqiong Du ◽  
Jinlin He ◽  
Jian Hu ◽  
Mingzu Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drugs ◽  
Anticancer Drug ◽  
Hydrophobic Interactions ◽  
Anticancer Drug Delivery ◽  
Dual Responsive

The paper focuses on the preparation of biodegradable pH/redox dual-responsive core-crosslinked nanoparticles loaded with dual anticancer drugs PTX and DOX via synergetic electrostatic as well as hydrophobic interactions and their further application in tumor chemotherapy.

Folate-conjugated dually responsive micelles for targeted anticancer drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (42) ◽  
pp. 35658-35667 ◽  
Author(s):  
Lingling Zhao ◽  
Yajuan Zhang ◽  
Jia Shao ◽  
Hongze Liang ◽  
Haining Na ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Anticancer Activity ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Dual Responsive

Folate-conjugated dual-responsive micelles were developed, sustained and sensitive drug release from the drug loaded micelles was observed. Folate-targeted micelles showed higher anticancer activity and enhanced cellar uptake than non-targeted ones.

scholarly journals Cathepsin B-Responsive Liposomes for Controlled Anticancer Drug Delivery in Hep G2 Cells

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 876
Author(s):  
Seulgi Lee ◽  
Su Jeong Song ◽  
Jeil Lee ◽  
Tai Hwan Ha ◽  
Joon Sig Choi
Keyword(s):  
Drug Delivery ◽  
Anticancer Drugs ◽  
Cancer Cell ◽  
Anticancer Drug ◽  
Cathepsin B ◽  
Chloride Salt ◽  
Hep G2 ◽  
Hep G2 Cells ◽  
Anticancer Drug Delivery ◽  
G2 Cells

In recent decades, several types of anticancer drugs that inhibit cancer cell growth and cause cell death have been developed for chemotherapeutic application. However, these agents are usually associated with side effects resulting from nonspecific delivery, which may induce cytotoxicity in healthy cells. To reduce the nonspecific delivery issue, nanoparticles have been successfully used for the delivery of anticancer drugs to specific target sites. In this study, a functional polymeric lipid, PEG-GLFG-K(C16)2 (PEG-GLFG, polyethylene glycol-Gly-Leu-Phe-Gly-Lys(C16)2), was synthesized to enable controlled anticancer drug delivery using cathepsin B enzyme-responsive liposomes. The liposomes composed of PEG-GLFG/DOTAP (1,2-dioleoyl-3-trimethylammonium-propane (chloride salt))/DPPC (dipalmitoylphosphatidylcholine)/cholesterol were prepared and characterized at various ratios. The GLFG liposomes formed were stable liposomes and were degraded when acted upon by cathepsin B enzyme. Doxorubicin (Dox) loaded GLFG liposomes (GLFG/Dox) were observed to exert an effective anticancer effect on Hep G2 cells in vitro and inhibit cancer cell proliferation in a zebrafish model.

Poly(N-isopropylacrylamide)-b-Poly(L-lysine)-b-Poly(L-histidine) Triblock Amphiphilic Copolymer Nanomicelles for Dual-Responsive Anticancer Drug Delivery

2020 ◽  
Vol 20 (11) ◽  
pp. 6959-6967
Author(s):  
Rimesh Augustine ◽  
Dae-Kyoung Kim ◽  
Ho An Kim ◽  
Jae Ho Kim ◽  
Il Kim
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Drug Loading ◽  
Anticancer Drug Delivery ◽  
Dual Responsive ◽  
Micellar Aggregates ◽  
Reversible Addition ◽  
Hydrogen Carbonate ◽  
Copolymer Micelle

A series of ABC triblock poly(N-isopropylacrylamide)75-block-poly(L-lysine)35-block-poly(L-histidine)n (p(NIPAM)75-b-p(Lys)35-b-p(His)N) (N = 35,50,75,100) copolymer bio-conjugates were prepared by combining reversible addition-fragmentation chain transfer polymerization and fast ring-opening polymerization of N-carboxyanhydride a-amino acid using 1,3-dicyclohexylimidazolium hydrogen carbonate as a catalyst. All the resulting triblock copolymers self-assembled into spherical micellar aggregates in aqueous solution, irrespective of the chain length of the histidine block. The micellar aggregates encapsulated the anticancer drug doxorubicin (Dox) and exhibited high drug loading efficiency. Temperature and pH stimuli were applied to investigate the controlled release of Dox. The non-cytotoxic nature of the polymers was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cellular uptake of the Dox-loaded micelles revealed that the micelles successfully release Dox in cancer cells in response to pH- and temperature-induced morphological change. In-vitro studies further confirmed that the Dox-loaded triblock copolymer micelle is an excellent platform for drug delivery.

Amphiphilic drug–drug assembly via dual-responsive linkages for small-molecule anticancer drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (71) ◽  
pp. 66420-66430 ◽  
Author(s):  
Tian Zhong ◽  
Ran Huang ◽  
Lianjiang Tan
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Small Molecule ◽  
Disulfide Bonds ◽  
Anticancer Drug Delivery ◽  
Dual Responsive ◽  
Amphiphilic Drug

Amphiphilic drug–drug assembly nanoparticles based on dual-responsive H-bonding-instructed disulfide bonds can release irinotecan and doxorubicin simultaneously in cancer cells for anticancer purposes.

NANOSTRUCTURED LIPOSOMAL SYSTEMS AS TRANSPORT AGENTS FOR ANTICANCER DRUGS

2012 ◽  
Vol 67 (3) ◽  
pp. 23-31 ◽  
Author(s):  
A. Yu. Baryshnikov
Keyword(s):  
Drug Delivery ◽  
Anticancer Drugs ◽  
Anticancer Drug ◽  
Cancer Chemotherapy ◽  
Biological Membranes ◽  
Liposomal Formulation ◽  
Anticancer Drug Delivery ◽  
Chemical Stimuli ◽  
Physical And Chemical ◽  
Selective Accumulation

Liposomes quite recently have turned from a model of biological membranes into an object of extensive research and practical use. The versatile traits of liposomal formulation allow its' universal implementation, especially in cancer chemotherapy. The advantages of liposomal use as a carrier of an anticancer drug for its targeted selective accumulation are discussed in this article. This article contains description of new types of liposomes, differing in contents and use, such as: simple, sterically stabilized, targeted (immunoliposomes),cationic, sensitive to physical and chemical stimuli. The characteristics of liposomal systems of anticancer drug delivery designed at Blokhin Russian Oncological Scientific Centre is given in the article.

Synthesis and Biological Studies of New Multifunctional Curcumin Platforms for Anticancer Drug Delivery

2019 ◽  
Vol 15 (5) ◽  
pp. 537-549
Author(s):  
Andrii Bazylevich ◽  
Helena Tuchinsky ◽  
Eti Zigman-Hoffman ◽  
Ran Weissman ◽  
Ofer Shpilberg ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Survival ◽  
Anticancer Drugs ◽  
Anticancer Drug ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Multiple Drug ◽  
Anticancer Drug Delivery ◽  
Biological Studies

Background: Scientists have extensively investigated curcumin, yielding many publications on treatments of cancer. Numerous derivatives of curcumin were synthesized, evaluated for their anti-oxidant and free-radical scavenging, SAR, ADME properties and tested in anticancer applications. Objective: We decided to exploit curcumin as a bioactive core platform for carrying anticancer drugs, which likely possesses a carboxyl moiety for potential linkage to the carrier for drug delivery. Methods: The goal of this work is to develop biolabile multifunctional curcumin platforms towards anticancer drug delivery, including determination of drug release profiling in hydrolytic media, in vitro cytotoxicity, antioxidant properties and blockage of relevant cell survival pathways. Results: We report on a facile synthesis of the bioactive multifunctional curcumin-based platforms linked to a variety of anticancer drugs like amonafide and chlorambucil, and release of the drugs in a hydrolytic environment. The leading curcumin-based platform has presented antioxidant activity similar to curcumin, but with much more potent cytotoxicity in vitro in agreement with the augmented blockage of the NF-kB cell survival pathway. Conclusion: The approach presented here may prove beneficial for bioactive curcumin-based delivery applications where multiple drug delivery is required in a consecutive and controlled mode.

scholarly journals Self-folded redox/acid dual-responsive nanocarriers for anticancer drug delivery

2014 ◽  
Vol 50 (95) ◽  
pp. 15105-15108 ◽  
Author(s):  
Yue Lu ◽  
Ran Mo ◽  
Wanyi Tai ◽  
Wujin Sun ◽  
Dennis B. Pacardo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Dual Responsive
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