Dual-Responsive Carbon Dots for Tumor Extracellular Microenvironment Triggered Targeting and Enhanced Anticancer Drug Delivery

2016 ◽  
Vol 8 (29) ◽  
pp. 18732-18740 ◽  
Author(s):  
Tao Feng ◽  
Xiangzhao Ai ◽  
Huimin Ong ◽  
Yanli Zhao
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Carbon Dots ◽  
Anticancer Drug Delivery ◽  
Dual Responsive ◽  
Extracellular Microenvironment

Folate-conjugated dually responsive micelles for targeted anticancer drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (42) ◽  
pp. 35658-35667 ◽  
Author(s):  
Lingling Zhao ◽  
Yajuan Zhang ◽  
Jia Shao ◽  
Hongze Liang ◽  
Haining Na ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Anticancer Activity ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Dual Responsive

Folate-conjugated dual-responsive micelles were developed, sustained and sensitive drug release from the drug loaded micelles was observed. Folate-targeted micelles showed higher anticancer activity and enhanced cellar uptake than non-targeted ones.

Heteroatom doped blue luminescent carbon dots as a nano-probe for targeted cell labeling and anticancer drug delivery vehicle

2019 ◽  
Vol 237 ◽  
pp. 121860 ◽  
Author(s):  
Poushali Das ◽  
Sayan Ganguly ◽  
Tarun Agarwal ◽  
Pritiprasanna Maity ◽  
Sabyasachi Ghosh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Carbon Dots ◽  
Cell Labeling ◽  
Delivery Vehicle ◽  
Drug Delivery Vehicle ◽  
Anticancer Drug Delivery

Poly(N-isopropylacrylamide)-b-Poly(L-lysine)-b-Poly(L-histidine) Triblock Amphiphilic Copolymer Nanomicelles for Dual-Responsive Anticancer Drug Delivery

2020 ◽  
Vol 20 (11) ◽  
pp. 6959-6967
Author(s):  
Rimesh Augustine ◽  
Dae-Kyoung Kim ◽  
Ho An Kim ◽  
Jae Ho Kim ◽  
Il Kim
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Drug Loading ◽  
Anticancer Drug Delivery ◽  
Dual Responsive ◽  
Micellar Aggregates ◽  
Reversible Addition ◽  
Hydrogen Carbonate ◽  
Copolymer Micelle

A series of ABC triblock poly(N-isopropylacrylamide)75-block-poly(L-lysine)35-block-poly(L-histidine)n (p(NIPAM)75-b-p(Lys)35-b-p(His)N) (N = 35,50,75,100) copolymer bio-conjugates were prepared by combining reversible addition-fragmentation chain transfer polymerization and fast ring-opening polymerization of N-carboxyanhydride a-amino acid using 1,3-dicyclohexylimidazolium hydrogen carbonate as a catalyst. All the resulting triblock copolymers self-assembled into spherical micellar aggregates in aqueous solution, irrespective of the chain length of the histidine block. The micellar aggregates encapsulated the anticancer drug doxorubicin (Dox) and exhibited high drug loading efficiency. Temperature and pH stimuli were applied to investigate the controlled release of Dox. The non-cytotoxic nature of the polymers was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cellular uptake of the Dox-loaded micelles revealed that the micelles successfully release Dox in cancer cells in response to pH- and temperature-induced morphological change. In-vitro studies further confirmed that the Dox-loaded triblock copolymer micelle is an excellent platform for drug delivery.

Amphiphilic drug–drug assembly via dual-responsive linkages for small-molecule anticancer drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (71) ◽  
pp. 66420-66430 ◽  
Author(s):  
Tian Zhong ◽  
Ran Huang ◽  
Lianjiang Tan
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Small Molecule ◽  
Disulfide Bonds ◽  
Anticancer Drug Delivery ◽  
Dual Responsive ◽  
Amphiphilic Drug

Amphiphilic drug–drug assembly nanoparticles based on dual-responsive H-bonding-instructed disulfide bonds can release irinotecan and doxorubicin simultaneously in cancer cells for anticancer purposes.

Photoresponsive quinoline tethered fluorescent carbon dots for regulated anticancer drug delivery

2013 ◽  
Vol 49 (89) ◽  
pp. 10471 ◽  
Author(s):  
S. Karthik ◽  
Biswajit Saha ◽  
Sudip Kumar Ghosh ◽  
N. D. Pradeep Singh
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Carbon Dots ◽  
Anticancer Drug Delivery ◽  
Fluorescent Carbon Dots ◽  
Fluorescent Carbon

scholarly journals Self-folded redox/acid dual-responsive nanocarriers for anticancer drug delivery

2014 ◽  
Vol 50 (95) ◽  
pp. 15105-15108 ◽  
Author(s):  
Yue Lu ◽  
Ran Mo ◽  
Wanyi Tai ◽  
Wujin Sun ◽  
Dennis B. Pacardo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Dual Responsive
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