Direct C–H arylation: a “Greener” approach towards facile synthesis of organic semiconducting molecules and polymers

2017 ◽  
Vol 5 (23) ◽  
pp. 11550-11571 ◽  
Author(s):  
Hassan Bohra ◽  
Mingfeng Wang
Keyword(s):  
Small Molecules ◽  
Facile Synthesis ◽  
Greener Synthesis ◽  
Organic Semiconducting Molecules

Direct C–H arylation enables “greener” synthesis of π-conjugated small molecules and polymers without tedious preactivation of C–H bonds.

A facile synthesis of novel polyaniline/graphene nanocomposite thin films for enzyme-free electrochemical sensing of hydrogen peroxide

2021 ◽  
Author(s):  
Swati Verma ◽  
Dipendra Singh Mal ◽  
Paulo R. Oliveira ◽  
Bruno Campos Janegitz ◽  
Jai Prakash ◽  
...  
Keyword(s):  
Thin Films ◽  
Hydrogen Peroxide ◽  
Small Molecules ◽  
Present Article ◽  
Electrochemical Method ◽  
Electrochemical Sensing ◽  
Facile Synthesis ◽  
Nanocomposite Thin Films ◽  
Graphene Nanocomposite

Electrochemical method is the most effective, facile, and economical approach for the detection of small molecules. The present article deals with design and engineering of polymer-graphene based thin films through...

Facile synthesis of naphthodithiophenediimide based small molecules and polymers via direct arylation coupling

2016 ◽  
Vol 57 (13) ◽  
pp. 1497-1501 ◽  
Author(s):  
Hassan Bohra ◽  
Jinjun Shao ◽  
Shuo Huang ◽  
Mingfeng Wang
Keyword(s):  
Small Molecules ◽  
Facile Synthesis ◽  
Direct Arylation

scholarly journals Site-Specific Fluorogenic Protein Labelling Agent for Bioconjugation

Biomolecules ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 369 ◽  
Author(s):  
Kelvin K. Tsao ◽  
Ann C. Lee ◽  
Karl É. Racine ◽  
Jeffrey W. Keillor
Keyword(s):  
Small Molecules ◽  
Functional Group ◽  
Cycloaddition Reaction ◽  
Facile Synthesis ◽  
Site Specific ◽  
Protein Labelling ◽  
Target Peptide ◽  
Labelling Method ◽  
Novel Protein

Many clinically relevant therapeutic agents are formed from the conjugation of small molecules to biomolecules through conjugating linkers. In this study, two novel conjugating linkers were prepared, comprising a central coumarin core, functionalized with a dimaleimide moiety at one end and a terminal alkyne at the other. In our first design, we developed a protein labelling method that site-specifically introduces an alkyne functional group to a dicysteine target peptide tag that was genetically fused to a protein of interest. This method allows for the subsequent attachment of azide-functionalized cargo in the facile synthesis of novel protein-cargo conjugates. However, the fluorogenic aspect of the reaction between the linker and the target peptide was less than we desired. To address this shortcoming, a second linker reagent was prepared. This new design also allowed for the site-specific introduction of an alkyne functional group onto the target peptide, but in a highly fluorogenic and rapid manner. The site-specific addition of an alkyne group to a protein of interest was thus monitored in situ by fluorescence increase, prior to the attachment of azide-functionalized cargo. Finally, we also demonstrated that the cargo can also be attached first, in an azide/alkyne cycloaddition reaction, prior to fluorogenic conjugation with the target peptide-fused protein.

Binary small molecule organic nanoparticles exhibit both direct and diffusion-limited ultrafast charge transfer with NIR excitation

Nanoscale ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 2385-2392 ◽  
Author(s):  
Bryan Kudisch ◽  
Margherita Maiuri ◽  
Leon Wang ◽  
Tristan Lim ◽  
Hoang Lu ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Charge Transfer ◽  
Small Molecules ◽  
Photoinduced Electron Transfer ◽  
Ultrafast Spectroscopy ◽  
Facile Synthesis ◽  
Organic Nanoparticles ◽  
Diffusion Limited ◽  
Ultrafast Charge Transfer ◽  
And Diffusion

We report the facile synthesis on new binary organic nanoparticles composed of NIR absorbing small molecules, which we show using ultrafast spectroscopy undergo photoinduced electron transfer.

scholarly journals DESIGN, FACILE SYNTHESIS, AND BIOLOGICAL EVALUATION OF NOVEL 1,3-THIAZINE DERIVATIVES AS POTENTIAL ANTICONVULSANT AGENTS

2016 ◽  
Vol 9 (5) ◽  
pp. 272 ◽  
Author(s):  
Ravindar B ◽  
Srinivasa Murthy M ◽  
Afzal Basha Shaik
Keyword(s):  
Small Molecules ◽  
Anticonvulsant Activity ◽  
Aromatic Aldehydes ◽  
Biological Evaluation ◽  
Important Class ◽  
Facile Synthesis ◽  
Anticonvulsant Agents ◽  
Anticonvulsant Activities ◽  
Synthesis And Biological Evaluation

ABSTRACTObjective: Chalcones and their heterocyclic analogs represent an important class of small molecules having anticonvulsant activities. Therefore, inthis study, the synthesis and anticonvulsant activity of some new chalcones and 1,3-thiazines were described.Methods: The reaction of 1-acetylnaphthalene with substituted aromatic aldehydes in the presence of aq. NaOH afforded corresponding chalconeswhich upon further cyclization with thiourea resulted in 1,3-thiazine derivatives. The newly synthesized compounds were tested for anticonvulsantactivity by pentylenetetrazole-induced seizures method using diazepam as standard.Results: Most of the compounds showed good anticonvulsant activity but is less than diazepam. 1,3-thiazines were more potent than chalconesand among them, compound P4 containing 4-fluorophenyl substituents on the thiazine moiety was more potent as it has prolonged the onset ofconvulsions by 155.2 seconds.Conclusion: We described the synthesis and anticonvulsant activity of novel chalcones and 1,3-thiazine derivatives. 1,3-thiazines are more activeanticonvulsant agents than chalcones and in particular compounds with electron withdrawing substituents.Keywords: Chalcone, 1,3-thiazine, Pentylenetetrazole.

Universality of the giant Seebeck effect in organic small molecules

2018 ◽  
Vol 2 (7) ◽  
pp. 1276-1283 ◽  
Author(s):  
Hirotaka Kojima ◽  
Ryo Abe ◽  
Fumiya Fujiwara ◽  
Mario Nakagawa ◽  
Kohtaro Takahashi ◽  
...  
Keyword(s):  
Seebeck Coefficient ◽  
Small Molecules ◽  
Seebeck Effect ◽  
Physical Models ◽  
Organic Semiconducting Molecules

Various pure organic semiconducting molecules exhibit extraordinarily large Seebeck coefficient which cannot be elucidated by conventional physical models of thermoelectricity.

Facile synthesis of 1-(2,6-diisopropylphenyl)-2,5-di(2-thienyl)pyrrole-based narrow band gap small molecules for solar cell applications

2013 ◽  
Vol 176 ◽  
pp. 96-103 ◽  
Author(s):  
Vellaiappillai Tamilavan ◽  
Myungkwan Song ◽  
Jae-Wook Kang ◽  
Myung Ho Hyun
Keyword(s):  
Solar Cell ◽  
Small Molecules ◽  
Band Gap ◽  
Narrow Band ◽  
Facile Synthesis

scholarly journals Facile synthesis of low band-gap DPP–EDOT containing small molecules for solar cell applications

RSC Advances ◽  
2017 ◽  
Vol 7 (46) ◽  
pp. 28788-28796 ◽  
Author(s):  
Venkatesan Govindan ◽  
Chun Guey Wu
Keyword(s):  
Solar Cell ◽  
Small Molecules ◽  
Band Gap ◽  
Facile Synthesis ◽  
Low Band Gap ◽  
Photovoltaic Applications ◽  
Donor Type ◽  
Donor Acceptor

Four donor–donor–acceptor–donor–donor type small molecules were synthesized (by direct alkylation) for photovoltaic applications.

Study on Biological Materials with Facile Synthesis and Anti-Breast Cancer Activities of Hydroxylchalcones Derivatives

2013 ◽  
Vol 830 ◽  
pp. 459-462
Author(s):  
Kun Jiang ◽  
Xin Fei Dong ◽  
Xiao Feng Lu ◽  
Jun Zhi Wang ◽  
Kun Zou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Small Molecules ◽  
Bioactive Compounds ◽  
Nmr Spectra ◽  
Aldol Condensation ◽  
Biological Materials ◽  
Facile Synthesis ◽  
Activity Evaluation ◽  
Proliferative Effect ◽  
Cancer Activity

Hydroxylchalcone are known to act on various physiological targets. In this study, a series of nine hydroxychalcones were synthesized via the aldol condensation with the aim of obtaining bioactive small molecules. Their structures were characterized by NMR spectra. The anti-breast cancer activity evaluation indicated the monohydroxychalcones exhibited the better anti-proliferative effect than dihydroxylchalcones against MDA-MB-231 cells, and the compound3bshowed the best anti-breast cancer activities at 18 μM. The bioactive compounds might be used to develop as potential anti-breast cancer agents.

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