Role of the supracellular actomyosin cable during epithelial wound healing

Soft Matter ◽  
2018 ◽  
Vol 14 (23) ◽  
pp. 4866-4873 ◽  
Author(s):  
Yanjun Yang ◽  
Herbert Levine
Keyword(s):  
Wound Healing ◽  
Epithelial Wound Healing

We demonstrate how the supracellular actomyosin cable contributes to the epithelial wound healing and its interplay with other mechanisms.

Role of the C Domain of IGFs in Synergistic Promotion, with a Substance P–Derived Peptide, of Rabbit Corneal Epithelial Wound Healing

2004 ◽  
Vol 45 (4) ◽  
pp. 1125 ◽  
Author(s):  
Naoyuki Yamada ◽  
Ryoji Yanai ◽  
Masatsugu Nakamura ◽  
Makoto Inui ◽  
Teruo Nishida
Keyword(s):  
Wound Healing ◽  
Substance P ◽  
Corneal Epithelial ◽  
Epithelial Wound Healing

The role of vesicle trafficking in epithelial cell motility

2009 ◽  
Vol 37 (5) ◽  
pp. 1072-1076 ◽  
Author(s):  
Sarah J. Fletcher ◽  
Joshua Z. Rappoport
Keyword(s):  
Wound Healing ◽  
Epithelial Cell ◽  
Cell Motility ◽  
Cancer Metastasis ◽  
Endosomal Recycling ◽  
Epithelial Cell Migration ◽  
Polarized Trafficking ◽  
Epithelial Wound Healing ◽  
Relevant Topic

Cell motility is important for many physiological and pathological processes including organ development, wound healing, cancer metastasis and correct immune responses. In particular, epithelial wound healing is both a medically relevant topic and a common experimental model. Mechanisms underlying generation of a polarized cell and maintenance of a motile phenotype during steady-state migration are not well understood. Polarized trafficking of bulk membrane and cell adhesion molecules has been implicated in regulation of cell motility. The present review focuses on the role of different trafficking pathways in epithelial cell migration, including clathrin-mediated endocytosis, caveolar endocytosis, exocytosis of biosynthetic cargo, ‘short-loop’ and ‘long-loop’ endosomal recycling.

scholarly journals Insulin and TOR signal in parallel through FOXO and S6K to promote epithelial wound healing

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Parisa Kakanj ◽  
Bernard Moussian ◽  
Sebastian Grönke ◽  
Victor Bustos ◽  
Sabine A. Eming ◽  
...  
Keyword(s):  
Wound Healing ◽  
Insulin Signalling ◽  
Myosin Ii ◽  
Glycogen Metabolism ◽  
Normal Wound Healing ◽  
Epithelial Wound Healing ◽  
Pi3k Activation ◽  
Diabetic Wound Healing ◽  
Growth Metabolism

Abstract The TOR and Insulin/IGF signalling (IIS) network controls growth, metabolism and ageing. Although reducing TOR or insulin signalling can be beneficial for ageing, it can be detrimental for wound healing, but the reasons for this difference are unknown. Here we show that IIS is activated in the cells surrounding an epidermal wound in Drosophila melanogaster larvae, resulting in PI3K activation and redistribution of the transcription factor FOXO. Insulin and TOR signalling are independently necessary for normal wound healing, with FOXO and S6K as their respective effectors. IIS is specifically required in cells surrounding the wound, and the effect is independent of glycogen metabolism. Insulin signalling is needed for the efficient assembly of an actomyosin cable around the wound, and constitutively active myosin II regulatory light chain suppresses the effects of reduced IIS. These findings may have implications for the role of insulin signalling and FOXO activation in diabetic wound healing.

scholarly journals Role of VIP and Sonic Hedgehog signaling pathways in mediating epithelial wound healing, sensory nerve regeneration and their defects in diabetic corneas

2020 ◽  
Author(s):  
Ada Admin ◽  
Yangyang Zhang ◽  
Nan Gao ◽  
Lin Wu ◽  
Patrick S. Y. Lee ◽  
...  
Keyword(s):  
Wound Healing ◽  
Nerve Regeneration ◽  
Sonic Hedgehog ◽  
Sensory Nerve ◽  
Dependent Manner ◽  
Corneal Wound Healing ◽  
Epithelial Wound Healing ◽  
Corneal Wound ◽  
Diabetic Keratopathy

Diabetic Keratopathy, a sight-threatening corneal disease, comprises several symptomatic conditions including delayed epithelial wound healing, recurrent erosions, and sensory nerve (SN) neuropathy. We investigated the role of neuropeptides in mediating corneal wound healing, including epithelial wound closure and SN regeneration. Denervation by Resiniferatoxin severely impaired corneal wound healing and markedly up-regulated pro-inflammatory gene expression. Exogenous neuropeptides CGRP, SP, and VIP partially reversed Resiniferatoxin’s effects, with VIP specifically inducing IL-10 expression. Hence, we focused on VIP and observed that wounding induced VIP and VIPR1 expression in normal (NL), but not diabetic (DM) mouse corneas. Targeting VIPR1 in <em>NL</em> corneas attenuated corneal wound healing, dampened wound-induced expression of neurotrophic factors, and exacerbated inflammatory responses while exogenous VIP had the opposite effects in DM corneas. Remarkably, wounding and diabetes also affected the expression of Sonic Hedgehog (SHH) in a VIP-dependent manner. Downregulating SHH expression in NL corneas decreased, while exogenous SHH in DM corneas increased the rates of corneal wound healing. Furthermore, inhibition of SHH signaling dampened VIP-promoted corneal wound healing. We conclude that VIP regulates epithelial wound he<a></a><a>aling, inflammatory response, and nerve regeneration in the corneas in a</a> SHH-dependent manner, suggesting a therapeutic potential for these molecules in treating diabetic keratopathy.

Functional Role of PPARδ in Corneal Epithelial Wound Healing

2012 ◽  
Vol 180 (2) ◽  
pp. 583-598 ◽  
Author(s):  
Yoshikuni Nakamura ◽  
Takahiro Nakamura ◽  
Takeshi Tarui ◽  
Jun Inoue ◽  
Shigeru Kinoshita
Keyword(s):  
Wound Healing ◽  
Functional Role ◽  
Corneal Epithelial ◽  
Epithelial Wound Healing

The role of PKC isoforms in gut epithelial wound healing in vitro

2001 ◽  
Vol 120 (5) ◽  
pp. A702-A702
Author(s):  
M LOTZ ◽  
C SONG ◽  
J MATTHEWS
Keyword(s):  
Wound Healing ◽  
Pkc Isoforms ◽  
Epithelial Wound Healing
Sign in / Sign up

Export Citation Format

Share Document