scholarly journals Role of Small GTPase Rho in Regulating Corneal Epithelial Wound Healing

2008 ◽  
Vol 49 (3) ◽  
pp. 900 ◽  
Author(s):  
Jia Yin ◽  
Jinshuang Lu ◽  
Fu-Shin X. Yu
Keyword(s):  
Wound Healing ◽  
Small Gtpase ◽  
Corneal Epithelial ◽  
Epithelial Wound Healing

Role of the C Domain of IGFs in Synergistic Promotion, with a Substance P–Derived Peptide, of Rabbit Corneal Epithelial Wound Healing

2004 ◽  
Vol 45 (4) ◽  
pp. 1125 ◽  
Author(s):  
Naoyuki Yamada ◽  
Ryoji Yanai ◽  
Masatsugu Nakamura ◽  
Makoto Inui ◽  
Teruo Nishida
Keyword(s):  
Wound Healing ◽  
Substance P ◽  
Corneal Epithelial ◽  
Epithelial Wound Healing

scholarly journals Rho kinases regulate corneal epithelial wound healing

2008 ◽  
Vol 295 (2) ◽  
pp. C378-C387 ◽  
Author(s):  
Jia Yin ◽  
Fu-Shin X. Yu
Keyword(s):  
Cell Proliferation ◽  
Wound Healing ◽  
Cell Migration ◽  
Rho Gtpase ◽  
Adhesion Formation ◽  
Small Gtpase ◽  
Corneal Epithelial Cell ◽  
Corneal Epithelial ◽  
Epithelial Wound Healing ◽  
Rho Kinases

We have previously shown that Rho small GTPase is required for modulating both cell migration and proliferation through cytoskeleton reorganization and focal adhesion formation in response to wounding. In the present study, we investigated the role of Rho kinases (ROCKs), major effectors of Rho GTPase, in mediating corneal epithelial wound healing. Both ROCK 1 and 2 were expressed and activated in THCE cells, an SV40-immortalized human corneal epithelial cell (HCEC) line, in response to wounding, lysophosphatidic acid, and heparin-binding EGF-like growth factor (HB-EGF) stimulations. The ROCK inhibitor Y-27632 efficiently antagonized ROCK activities without affecting Rho activation in wounded HCECs. Y-27632 promoted basal and HB-EGF-enhanced scratch wound healing and enhanced cell migration and adhesion to matrices, while retarded HB-EGF induced cell proliferation. E-cadherin- and β-catenin-mediated cell-cell junction and actin cytoskeleton organization were disrupted by Y-27632. Y-27632 impaired the formation and maintenance of tight junction barriers indicated by decreased trans-epithelial resistance and disrupted occludin staining. We conclude that ROCK activities enhance cell proliferation, promote epithelial differentiation, but negatively modulate cell migration and cell adhesion and therefore play a role in regulating corneal epithelial wound healing.

Functional Role of PPARδ in Corneal Epithelial Wound Healing

2012 ◽  
Vol 180 (2) ◽  
pp. 583-598 ◽  
Author(s):  
Yoshikuni Nakamura ◽  
Takahiro Nakamura ◽  
Takeshi Tarui ◽  
Jun Inoue ◽  
Shigeru Kinoshita
Keyword(s):  
Wound Healing ◽  
Functional Role ◽  
Corneal Epithelial ◽  
Epithelial Wound Healing

Important Role of Epiregulin in Inflammatory Responses during Corneal Epithelial Wound Healing

2012 ◽  
Vol 53 (4) ◽  
pp. 2414 ◽  
Author(s):  
Yuan Zhang ◽  
Takeshi Kobayashi ◽  
Yasuhito Hayashi ◽  
Ryuji Yoshioka ◽  
Atsushi Shiraishi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Inflammatory Responses ◽  
Corneal Epithelial ◽  
Epithelial Wound Healing

scholarly journals Role of ErbB2 in Corneal Epithelial Wound Healing

2004 ◽  
Vol 45 (12) ◽  
pp. 4277 ◽  
Author(s):  
Ke-Ping Xu ◽  
April Riggs ◽  
Yu Ding ◽  
Fu-Shin X. Yu
Keyword(s):  
Wound Healing ◽  
Corneal Epithelial ◽  
Epithelial Wound Healing

Effects of the COOH-terminal tripeptide α-MSH11–13 on corneal epithelial wound healing: Role of nitric oxide

2006 ◽  
Vol 83 (6) ◽  
pp. 1366-1372 ◽  
Author(s):  
Vincenza Bonfiglio ◽  
Giovanni Camillieri ◽  
Teresio Avitabile ◽  
Gian Marco Leggio ◽  
Filippo Drago
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Corneal Epithelial ◽  
Epithelial Wound Healing

scholarly journals The Role of Toll-Like Receptor 4 in Corneal Epithelial Wound Healing

2014 ◽  
Vol 55 (9) ◽  
pp. 6108 ◽  
Author(s):  
Medi Eslani ◽  
Asadolah Movahedan ◽  
Neda Afsharkhamseh ◽  
Herve Sroussi ◽  
Ali R. Djalilian
Keyword(s):  
Wound Healing ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Corneal Epithelial ◽  
Epithelial Wound Healing

The role of the Nrf2-mediated defense system in corneal epithelial wound healing

2013 ◽  
Vol 61 ◽  
pp. 333-342 ◽  
Author(s):  
Ryuhei Hayashi ◽  
Noriko Himori ◽  
Keiko Taguchi ◽  
Yuki Ishikawa ◽  
Kohji Uesugi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Defense System ◽  
Corneal Epithelial ◽  
Epithelial Wound Healing
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