scholarly journals Control of aggregation temperatures in mixed and blended cytocompatible thermoresponsive block co-polymer nanoparticles

Soft Matter ◽  
2017 ◽  
Vol 13 (40) ◽  
pp. 7441-7452 ◽  
Author(s):  
Ruggero Foralosso ◽  
Lee Moir ◽  
Francesca Mastrotto ◽  
Luana Sasso ◽  
Aleksandra Tchoryk ◽  
...  
Keyword(s):  
Polymer Nanoparticles ◽  
Amphiphilic Copolymers ◽  
Temperature Responsive

Blends of amphiphilic copolymers and mixtures of their nanoparticles can be tuned for temperature-responsive behaviour.

Synthesis of a dual pH and temperature responsive star triblock copolymer based on β-cyclodextrins for controlled intracellular doxorubicin delivery release

2016 ◽  
Vol 40 (10) ◽  
pp. 8397-8407 ◽  
Author(s):  
Beibei Lu ◽  
Lei Li ◽  
Jianning Wu ◽  
Lulu Wei ◽  
Jun Hou ◽  
...  
Keyword(s):  
Triblock Copolymer ◽  
Amphiphilic Copolymers ◽  
Temperature Responsive ◽  
Doxorubicin Delivery ◽  
Star Triblock Copolymer

Well-defined dual pH and temperature responsive triblock star-shaped amphiphilic copolymers of β-CD-g-(PHEMA-b-PNIPAM-b-PDMAEMA)3 were synthesized by the combination of RAFT polymerizations.

Retrieval of resorptive human osteoclasts from temperature-responsive plastic

2016 ◽  
Author(s):  
Arjen Gebraad ◽  
Teuvo Hentunen ◽  
Tiina Laitala-Leinonen
Keyword(s):  
Temperature Responsive ◽  
Human Osteoclasts

Bottom-up Evolution from Disks to High-Genus Polymersomes

2018 ◽  
Author(s):  
Claudia Contini ◽  
Russell Pearson ◽  
Linge Wang ◽  
Lea Messager ◽  
Jens Gaitzsch ◽  
...  
Keyword(s):  
Self Assembly ◽  
The Self ◽  
Amphiphilic Copolymers ◽  
Chain Entanglement ◽  
Bottom Up ◽  
New Approach ◽  
High Genus ◽  
Transmission Electron ◽  
Minimal Radius ◽  
Stop Flow

<div><div><div><p>We report the design of polymersomes using a bottom-up approach where the self-assembly of amphiphilic copolymers poly(2-(methacryloyloxy) ethyl phosphorylcholine)–poly(2-(diisopropylamino) ethyl methacrylate) (PMPC-PDPA) into membranes is tuned using pH and temperature. We study this process in detail using transmission electron microscopy (TEM), nuclear magnetic resonance (NMR) spectroscopy, dynamic light scattering (DLS), and stop-flow ab- sorbance disclosing the molecular and supramolecular anatomy of each structure observed. We report a clear evolution from disk micelles to vesicle to high-genus vesicles where each passage is controlled by pH switch or temperature. We show that the process can be rationalised adapting membrane physics theories disclosing important scaling principles that allow the estimation of the vesiculation minimal radius as well as chain entanglement and coupling. This allows us to propose a new approach to generate nanoscale vesicles with genus from 0 to 70 which have been very elusive and difficult to control so far.</p></div></div></div>

Bottom-up Evolution from Disks to High-Genus Polymersomes

2018 ◽  
Author(s):  
Claudia Contini ◽  
Russell Pearson ◽  
Linge Wang ◽  
Lea Messager ◽  
Jens Gaitzsch ◽  
...  
Keyword(s):  
Self Assembly ◽  
The Self ◽  
Amphiphilic Copolymers ◽  
Chain Entanglement ◽  
Bottom Up ◽  
New Approach ◽  
High Genus ◽  
Transmission Electron ◽  
Minimal Radius ◽  
Stop Flow

<div><div><div><p>We report the design of polymersomes using a bottom-up approach where the self-assembly of amphiphilic copolymers poly(2-(methacryloyloxy) ethyl phosphorylcholine)–poly(2-(diisopropylamino) ethyl methacrylate) (PMPC-PDPA) into membranes is tuned using pH and temperature. We study this process in detail using transmission electron microscopy (TEM), nuclear magnetic resonance (NMR) spectroscopy, dynamic light scattering (DLS), and stop-flow ab- sorbance disclosing the molecular and supramolecular anatomy of each structure observed. We report a clear evolution from disk micelles to vesicle to high-genus vesicles where each passage is controlled by pH switch or temperature. We show that the process can be rationalised adapting membrane physics theories disclosing important scaling principles that allow the estimation of the vesiculation minimal radius as well as chain entanglement and coupling. This allows us to propose a new approach to generate nanoscale vesicles with genus from 0 to 70 which have been very elusive and difficult to control so far.</p></div></div></div>

Influence of Divalent Cation on Morphology and Drug Delivery Efficiency of Mixed Polymer Nanoparticles

2018 ◽  
Vol 15 (5) ◽  
pp. 652-657 ◽  
Author(s):  
Ramachandran Deepika ◽  
Koyeli Girigoswami ◽  
Ramachandran Murugesan ◽  
Agnishwar Girigoswami
Keyword(s):  
Drug Delivery ◽  
Divalent Cation ◽  
Polymer Nanoparticles ◽  
Delivery Efficiency

Synthesis of Amphiphilic Copolymers of Acrylic Acid and Styrene with the Desired Microstructure and Their Properties

2020 ◽  
Vol 62 (6) ◽  
pp. 649-659
Author(s):  
K. O. Mineeva ◽  
N. I. Osipova ◽  
S. D. Zaitsev ◽  
A. V. Plutalova ◽  
E. I. Medentseva ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Amphiphilic Copolymers
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