Temperature-Responsive Properties and Drug Solubilization Capacity of Amphiphilic Copolymers Based onN-Vinylpyrrolidone and Vinyl Propyl Ether

Langmuir ◽  
2010 ◽  
Vol 26 (10) ◽  
pp. 7590-7597 ◽  
Author(s):  
Daulet E. Zhunuspayev ◽  
Grigoriy A. Mun ◽  
Vitaliy V. Khutoryanskiy
Keyword(s):  
Amphiphilic Copolymers ◽  
Drug Solubilization ◽  
Temperature Responsive ◽  
Solubilization Capacity

scholarly journals Control of aggregation temperatures in mixed and blended cytocompatible thermoresponsive block co-polymer nanoparticles

Soft Matter ◽  
2017 ◽  
Vol 13 (40) ◽  
pp. 7441-7452 ◽  
Author(s):  
Ruggero Foralosso ◽  
Lee Moir ◽  
Francesca Mastrotto ◽  
Luana Sasso ◽  
Aleksandra Tchoryk ◽  
...  
Keyword(s):  
Polymer Nanoparticles ◽  
Amphiphilic Copolymers ◽  
Temperature Responsive

Blends of amphiphilic copolymers and mixtures of their nanoparticles can be tuned for temperature-responsive behaviour.

MICROEMULSIONS: A NOVEL DRUG CARRIER SYSTEM

2009 ◽  
Vol 1 (2) ◽  
Author(s):  
Y. Rao ◽  
K. Deepthi ◽  
K.P. Chowdary
Keyword(s):  
Drug Carrier ◽  
Research Work ◽  
Drug Carriers ◽  
Microemulsion Formulation ◽  
Carrier System ◽  
Interfacial Film ◽  
Drug Solubilization ◽  
Solubilization Capacity ◽  
Drug Carrier System ◽  
Novel Drug

Microemulsions are clear, transparent, thermodynamically stable dispersions of oil and water, stabilized by an interfacial film of surfactant frequently in combination with a co-surfactant. Recently, there has been a considerable interest for the microemulsion formulation, for the delivery of hydrophilic as well as lipophilic drug as drug carriers because of its improved drug solubilization capacity, long shelf life, easy of preparation and improvement of bioavailability. In this present review, we discuss about the various advantages of microemulsion in pharmaceuticals, along with its preparation, evaluation and research work carried out on microemulsions.

Synthesis of a dual pH and temperature responsive star triblock copolymer based on β-cyclodextrins for controlled intracellular doxorubicin delivery release

2016 ◽  
Vol 40 (10) ◽  
pp. 8397-8407 ◽  
Author(s):  
Beibei Lu ◽  
Lei Li ◽  
Jianning Wu ◽  
Lulu Wei ◽  
Jun Hou ◽  
...  
Keyword(s):  
Triblock Copolymer ◽  
Amphiphilic Copolymers ◽  
Temperature Responsive ◽  
Doxorubicin Delivery ◽  
Star Triblock Copolymer

Well-defined dual pH and temperature responsive triblock star-shaped amphiphilic copolymers of β-CD-g-(PHEMA-b-PNIPAM-b-PDMAEMA)3 were synthesized by the combination of RAFT polymerizations.

More Is Less: Curcumin and Paclitaxel Formulations Using Poly(2-Oxazoline) and Poly(2-Oxazine) Based Amphiphiles Bearing Linear and Branched C9 Side Chains

2018 ◽  
Author(s):  
Michael M. Lübtow ◽  
Larissa Keßler ◽  
Thomas Lorson ◽  
Niklas Gangloff ◽  
Marius Kirsch ◽  
...  
Keyword(s):  
Triblock Copolymers ◽  
Side Chain ◽  
Side Chains ◽  
General Strategy ◽  
Loading Capacity ◽  
Hydrophobic Core ◽  
Polymer Micelles ◽  
Drug Solubilization ◽  
Solubilization Capacity ◽  
Insoluble Compounds

p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 11.0px Helvetica} <p>A known limitation of polymer micelles for the formulation of hydrophobic drugs is their low loading capacity, which rarely exceeds 20 wt.%. One general strategy to overcome this limitation is to increase the amphiphilic contrast, i.e. to make the hydrophobic core of the micelles more hydrophobic. However, we reported earlier that for poly(2-oxazoline) based amphiphilic triblock copolymers, a minimal amphiphilic contrast is beneficial, which was tentatively attributed to possible side chain crystallization. Here, we revisit this subject in more detail using more hydrophobic side chains that are either linear (nonyl) or branched (3-ethylheptyl), the latter of which should not crystallize. Moreover, we investigate two different backbones within the hydrophobic block, in particular poly(2-oxazoline) and poly(2-oxazine), for the solubilization and co-solubilization of the two highly water insoluble compounds curcumin and paclitaxel. Even though high loading capacities could be achieved for curcumin within poly(2-oxazine) based triblock copolymers, the solubilization capacity of all investigated polymers with longer side chains was significantly lower compared to poly(2-oxazoline)s and poly(2-oxazine)s with shorter side chains. Although the even lower loading capacity for paclitaxel could be somehow attenuated by co-formulating curcumin, this study corroborates that in the case of poly(2-oxazoline) and poly(2-oxazine) based polymer micelles, an increased amphiphilic contrast leads to less drug solubilization.</p>

Computational Models of the Gastrointestinal Environment. 2. Phase Behavior and Drug Solubilization Capacity of a Type I Lipid-Based Drug Formulation after Digestion

2017 ◽  
Vol 14 (3) ◽  
pp. 580-592 ◽  
Author(s):  
Woldeamanuel A. Birru ◽  
Dallas B. Warren ◽  
Sifei Han ◽  
Hassan Benameur ◽  
Christopher J. H. Porter ◽  
...  
Keyword(s):  
Phase Behavior ◽  
Computational Models ◽  
Drug Formulation ◽  
Type I ◽  
Drug Solubilization ◽  
Solubilization Capacity

More Is Less: Curcumin and Paclitaxel Formulations Using Poly(2-Oxazoline) and Poly(2-Oxazine) Based Amphiphiles Bearing Linear and Branched C9 Side Chains

2018 ◽  
Author(s):  
Michael M. Lübtow ◽  
Larissa Keßler ◽  
Thomas Lorson ◽  
Niklas Gangloff ◽  
Marius Kirsch ◽  
...  
Keyword(s):  
Triblock Copolymers ◽  
Side Chain ◽  
Side Chains ◽  
General Strategy ◽  
Loading Capacity ◽  
Hydrophobic Core ◽  
Polymer Micelles ◽  
Drug Solubilization ◽  
Solubilization Capacity ◽  
Insoluble Compounds

p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 11.0px Helvetica} <p>A known limitation of polymer micelles for the formulation of hydrophobic drugs is their low loading capacity, which rarely exceeds 20 wt.%. One general strategy to overcome this limitation is to increase the amphiphilic contrast, i.e. to make the hydrophobic core of the micelles more hydrophobic. However, we reported earlier that for poly(2-oxazoline) based amphiphilic triblock copolymers, a minimal amphiphilic contrast is beneficial, which was tentatively attributed to possible side chain crystallization. Here, we revisit this subject in more detail using more hydrophobic side chains that are either linear (nonyl) or branched (3-ethylheptyl), the latter of which should not crystallize. Moreover, we investigate two different backbones within the hydrophobic block, in particular poly(2-oxazoline) and poly(2-oxazine), for the solubilization and co-solubilization of the two highly water insoluble compounds curcumin and paclitaxel. Even though high loading capacities could be achieved for curcumin within poly(2-oxazine) based triblock copolymers, the solubilization capacity of all investigated polymers with longer side chains was significantly lower compared to poly(2-oxazoline)s and poly(2-oxazine)s with shorter side chains. Although the even lower loading capacity for paclitaxel could be somehow attenuated by co-formulating curcumin, this study corroborates that in the case of poly(2-oxazoline) and poly(2-oxazine) based polymer micelles, an increased amphiphilic contrast leads to less drug solubilization.</p>

Retrieval of resorptive human osteoclasts from temperature-responsive plastic

2016 ◽  
Author(s):  
Arjen Gebraad ◽  
Teuvo Hentunen ◽  
Tiina Laitala-Leinonen
Keyword(s):  
Temperature Responsive ◽  
Human Osteoclasts
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