scholarly journals A mitochondria-targeted nanoradiosensitizer activating reactive oxygen species burst for enhanced radiation therapy

2018 ◽  
Vol 9 (12) ◽  
pp. 3159-3164 ◽  
Author(s):  
Na Li ◽  
Longhai Yu ◽  
Jianbo Wang ◽  
Xiaonan Gao ◽  
Yuanyuan Chen ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Titanium Dioxide ◽  
Radiation Therapy ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Novel Strategy ◽  
Reactive Oxygen Species Burst

We developed a novel strategy for enhanced radiation therapy based on a mitochondria targeted titanium dioxide-gold nanoradiosensitizer.

scholarly journals Correction: A mitochondria-targeted nanoradiosensitizer activating reactive oxygen species burst for enhanced radiation therapy

2020 ◽  
Vol 11 (30) ◽  
pp. 8039-8039
Author(s):  
Na Li ◽  
Longhai Yu ◽  
Jianbo Wang ◽  
Xiaonan Gao ◽  
Yuanyuan Chen ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Radiation Therapy ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Reactive Oxygen Species Burst

Correction for ‘A mitochondria-targeted nanoradiosensitizer activating reactive oxygen species burst for enhanced radiation therapy’ by Na Li et al., Chem. Sci., 2018, 9, 3159–3164, DOI: 10.1039/C7SC04458E.

Endogenous reactive oxygen species burst induced and spatiotemporally controlled multiple drug release by traceable nanoparticles for enhancing antitumor efficacy

2021 ◽  
Author(s):  
Ning Wang ◽  
Chenyu Liu ◽  
Weihe Yao ◽  
Hengjun Zhou ◽  
Simiao Yu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Release ◽  
Reactive Oxygen ◽  
Combined Effect ◽  
Antitumor Efficacy ◽  
Multiple Drug ◽  
Oxygen Species ◽  
Anticancer Effects ◽  
Endogenous Reactive Oxygen Species ◽  
Reactive Oxygen Species Burst

Reactive oxygen species (ROS) are not only used as a therapeutic reagent in chemodynamic therapy (CDT), to stimulate the release of drugs, they can also be used to achieve a combined effect of CDT and chemotherapy to enhance anticancer effects.

scholarly journals Radiation therapy-induced reactive oxygen species specifically eliminates CD19+ IgA+ B cells in nasopharyngeal carcinoma

2019 ◽  
Vol Volume 11 ◽  
pp. 6299-6309 ◽  
Author(s):  
Weiwei Li ◽  
Luman Wang ◽  
Chunying Shen ◽  
Tingting Xu ◽  
Yiwei Chu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Radiation Therapy ◽  
B Cells ◽  
Nasopharyngeal Carcinoma ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Role of Natural Radiosensitizers and Cancer Cell Radioresistance: An Update

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Arif Malik ◽  
Misbah Sultana ◽  
Aamer Qazi ◽  
Mahmood Husain Qazi ◽  
Gulshan Parveen ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Radiation Therapy ◽  
Cancer Stem Cells ◽  
Ionizing Radiation ◽  
Malignant Tumors ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Ros Scavenging

Cancer originates from genetic mutations accumulation. Cancer stem cells have been depicted as tumorigenic cells that can differentiate and self-renew. Cancer stem cells are thought to be resistant to conventional therapy like chemotherapy and radiation therapy. Radiation therapy and chemotherapy damage carcinomic DNA cells. Because of the ability of cancer stem cells to self-renew and reproduce malignant tumors, they are the subject of intensive research. In this review, CSCs radioresistant mechanisms which include DNA damage response and natural radiosensitizers have been summed up. Reactive oxygen species play an important role in different physiological processes. ROS scavenging is responsible for regulation of reactive oxygen species generation. A researcher has proved that microRNAs regulate tumor radiation resistance. Ionizing radiation does not kill the cancer cells; rather, IR just slows down the signs and symptoms. Ionizing radiation damages DNA directly/indirectly. IR is given mostly in combination with other chemo/radiotherapies. We briefly described here the behavior of cancer stem cells and radioresistance therapies in cancer treatment. To overcome radioresistance in treatment of cancer, strategies like fractionation modification, treatment in combination, inflammation modification, and overcoming hypoxic tumor have been practiced. Natural radiosensitizers, for example, curcumin, genistein, and quercetin, are more beneficial than synthetic compounds.

Toxicity of Titanium Dioxide Nanoparticles Induced by Reactive Oxygen Species

2019 ◽  
Author(s):  
Di Zhou ◽  
Shuo Han ◽  
Tenglong Yan ◽  
Changmao Long ◽  
Jiayu Xu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Reactive Oxygen ◽  
Oxygen Species

Uniform zinc thioporphyrazine nanosphere by self-assembly and the photocatalytic performance

2018 ◽  
Vol 22 (09n10) ◽  
pp. 868-876 ◽  
Author(s):  
Changjun Yang ◽  
Lanchang Gao ◽  
Bingguang Zhang ◽  
Zehui Zhang ◽  
Kejian Deng
Keyword(s):  
Reactive Oxygen Species ◽  
Self Assembly ◽  
Photocatalytic Performance ◽  
Aqueous Media ◽  
Reactive Oxygen ◽  
Polymerization Reaction ◽  
Oxygen Species ◽  
Paramagnetic Resonance ◽  
Novel Strategy ◽  
Means Of Transmission

A novel strategy for the synthesis of zinc thioporphyrazine nanospheres is presented. The uniform spheres were fabricated through a polymerization reaction without using any template or emulsifier, which result from the covalent links between zinc tetra(2,3-bis(pentenylthio)porphyrazine (ZnPz) possessing eight long flexible chains in periphery and each with one terminal olefin group. A possible mechanism to explain the self-assembly of ZnPz nanospheres was also illuminated through monitoring nanosphere formation by means of transmission electron microscopy (TEM). More importantly, ZnPz nanospheres can effectively activate dioxygen in aqueous media under simulated sunlight irradiation, and showed significantly improved photocatalytic activity for the degradation of Rhodamine B (RhB) as compared to monomeric ZnPz. Furthermore, the reactive oxygen species derived from ZnPz nanospheres under light irradiation were determined by electron paramagnetic resonance (EPR) technology, indicating that singlet oxygen ([Formula: see text]O[Formula: see text] and hydroxyl radical (•OH) are the major reactive oxygen species. The facile synthetic methodology and the enhanced photocatalytic performance of the ZnPz nanospheres endow this novel material with the potential of being an efficient biomimetic photocatalyst for wastewater treatment.

Titanium Dioxide (P25) Produces Reactive Oxygen Species in Immortalized Brain Microglia (BV2):  Implications for Nanoparticle Neurotoxicity†

2006 ◽  
Vol 40 (14) ◽  
pp. 4346-4352 ◽  
Author(s):  
Thomas C. Long ◽  
Navid Saleh ◽  
Robert D. Tilton ◽  
Gregory V. Lowry ◽  
Bellina Veronesi
Keyword(s):  
Reactive Oxygen Species ◽  
Titanium Dioxide ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Herbivore-derived fatty-acid amides elicit reactive oxygen species burst in plants

2017 ◽  
Vol 69 (5) ◽  
pp. 1235-1245 ◽  
Author(s):  
Anna Block ◽  
Shawn A Christensen ◽  
Charles T Hunter ◽  
Hans T Alborn
Keyword(s):  
Reactive Oxygen Species ◽  
Fatty Acid ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Fatty Acid Amides ◽  
Reactive Oxygen Species Burst
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