Titanium Dioxide (P25) Produces Reactive Oxygen Species in Immortalized Brain Microglia (BV2):  Implications for Nanoparticle Neurotoxicity†

2006 ◽  
Vol 40 (14) ◽  
pp. 4346-4352 ◽  
Author(s):  
Thomas C. Long ◽  
Navid Saleh ◽  
Robert D. Tilton ◽  
Gregory V. Lowry ◽  
Bellina Veronesi
Keyword(s):  
Reactive Oxygen Species ◽  
Titanium Dioxide ◽  
Reactive Oxygen ◽  
Oxygen Species

Toxicity of Titanium Dioxide Nanoparticles Induced by Reactive Oxygen Species

2019 ◽  
Author(s):  
Di Zhou ◽  
Shuo Han ◽  
Tenglong Yan ◽  
Changmao Long ◽  
Jiayu Xu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Reactive Oxygen ◽  
Oxygen Species

Characterization by Electron Spin Resonance Spectroscopy of Reactive Oxygen Species Generated by Titanium Dioxide and Hydrogen Peroxide

2005 ◽  
Vol 84 (2) ◽  
pp. 178-182 ◽  
Author(s):  
M.-C. Lee ◽  
F. Yoshino ◽  
H. Shoji ◽  
S. Takahashi ◽  
K. Todoki ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Titanium Dioxide ◽  
Electron Spin Resonance ◽  
Electron Spin ◽  
Reactive Oxygen ◽  
Titanium Implants ◽  
Spin Adduct ◽  
Oxygen Species ◽  
Spin Concentration ◽  
Spin Resonance

The influence of reactive oxygen species (ROS) on the surface modification of titanium implants and osseointegration is unclear. The aim of this study was to evaluate the ability of titanium dioxide (TiO2) to generate ROS in the presence of H2O2 and to determine whether any ROS thus generated play a role in osseointegration, as measured by electron spin resonance (ESR) spin-trapping with 5,5-dimethyl-1-pyrolline- N-oxide (DMPO). We demonstrate that TiO2 together with H2O2 generated hydroxyl radicals (HO•), as shown by a time-dependent increase in the spin concentration of the ESR signal for the DMPO-OH spin adduct, indicating HO• generation. Interestingly, irradiated TiO2 with H2O2 generated the superoxide (O2•-), as shown by an increase in the spin concentration of the signal for the DMPO-OOH spin adduct, indicating O2•- generation during the period of irradiation (0–5 min). These results suggest that ROS generated from the TiO2 layer may be involved in creating appropriate conditions for the osseointegration of dental implants into alveolar bone tissues.

scholarly journals Nanosize Titanium Dioxide Stimulates Reactive Oxygen Species in Brain Microglia and Damages Neurons in Vitro

2007 ◽  
Vol 115 (11) ◽  
pp. 1631-1637 ◽  
Author(s):  
Thomas C. Long ◽  
Julianne Tajuba ◽  
Preethi Sama ◽  
Navid Saleh ◽  
Carol Swartz ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Titanium Dioxide ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Reactive oxygen species damage drives cardiac and mitochondrial dysfunction following acute nano-titanium dioxide inhalation exposure

2017 ◽  
Vol 12 (1) ◽  
pp. 32-48 ◽  
Author(s):  
Cody E. Nichols ◽  
Danielle L. Shepherd ◽  
Quincy A. Hathaway ◽  
Andrya J. Durr ◽  
Dharendra Thapa ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Titanium Dioxide ◽  
Mitochondrial Dysfunction ◽  
Inhalation Exposure ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Nano Titanium Dioxide

scholarly journals Titanium Dioxide Induces Apoptosis under UVA Irradiation via the Generation of Lysosomal Membrane Permeabilization-Dependent Reactive Oxygen Species in HaCat Cells

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1943
Author(s):  
In-Young Kim ◽  
Tae-Geol Lee ◽  
Vytas Reipa ◽  
Min-Beom Heo
Keyword(s):  
Reactive Oxygen Species ◽  
Titanium Dioxide ◽  
Reactive Oxygen ◽  
Membrane Permeabilization ◽  
Ros Generation ◽  
Hacat Cells ◽  
Oxygen Species ◽  
Tio2 Nps ◽  
Lysosomal Membrane Permeabilization ◽  
Uva Irradiation

Titanium dioxide nanoparticles (TiO2 NPs) have wide commercial applications, owing to their small size; however, the biosafety of TiO2 NPs should be evaluated further. In this study, we aimed to investigate the cytotoxicity of TiO2 NPs in the presence and absence of ultraviolet A (UVA) irradiation in human keratinocyte HaCaT cells. TiO2 NPs did not significantly affect cell viability in the absence of UVA irradiation. Nonetheless, UVA-irradiated TiO2 NPs induced caspase-dependent apoptosis of HaCaT cells. Exposure of HaCaT cells to TiO2 NPs and UVA resulted in reactive oxygen species (ROS) generation and lysosomal membrane permeabilization (LMP); both effects were not observed in the absence of UVA irradiation. An analysis of the relationship between LMP and ROS, using CA-074 as a cathepsin inhibitor or NAC as an antioxidant, showed that LMP stimulates ROS generation under these conditions. These results imply that LMP-dependent oxidative stress plays a critical role in the UVA phototoxicity of TiO2 NPs in HaCaT cells.

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