scholarly journals Chemometric modeling of larvicidal activity of plant derived compounds against zika virus vectorAedes aegypti: application of ETA indices

RSC Advances ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. 4662-4670 ◽  
Author(s):  
Priyanka De ◽  
Rahul B. Aher ◽  
Kunal Roy
Keyword(s):  
Public Health ◽  
Aedes Aegypti ◽  
Larvicidal Activity ◽  
Zika Virus ◽  
Qsar Model ◽  
Health Concerns

Dengue, zika and chikungunya have severe public health concerns in several countries. We have developed here a QSAR model for larvicidal activity of plant derived compounds against the vectorAedes aegypti.

scholarly journals LARVICIDAL ACTIVITY OF Caesalpinia ferrea MART. AND Lippia origanoides CHAM. AGAINST Aedes aegypti (LINNAEUS, 1762) (DIPTERA: CULICIDAE)

2020 ◽  
Vol 49 (1) ◽  
pp. 45-54
Author(s):  
Thiago Andre Santos de Andrade ◽  
Ivanise Maria de Santana ◽  
George Chaves Jimenez ◽  
Eulina Tereza Nery Farias ◽  
Lucia Oliveira de Macedo ◽  
...  
Keyword(s):  
Public Health ◽  
Aedes Aegypti ◽  
Larvicidal Activity ◽  
Ethanol Extract ◽  
Chemical Compounds ◽  
Botanical Insecticide ◽  
Plant Metabolites ◽  
Important Public Health ◽  
Public Health Challenges ◽  
Ethanol Extracts

The control of Aedes aegypti has been considered one of the most important public health challenges worldwide. Chemical compounds have long been used for this purpose, but resistance to these molecules has also increased. Therefore, over the last few years several studies have focused on the development of alternative tools, particularly those based on plant metabolites. The purpose of this study was to assess the larvicidal activity of Caesalpinia ferrea and Lippia origanoides against Ae. aegypti. Larvae (L3) of Ae. aegypti Liverpool and Rockefeller strains, as well as of the Recife population were exposed to different concentrations  of C. ferrea (ranging from 13.1 to 105 mg/mL) and L. origanoides (ranging from 16.3 to 130 mg/mL), and the mortality rate was evaluated up to 48 hours after the beginning of the experiment. All tested groups and  ontrol group were quadruplicated. For C. ferrea, mortality ranged from 42.5% to 100% for Ae. aegypti Liverpool strain,from 67% to 100% for Ae. aegypti Rockfeller strain, and 57% to 100% for Ae. aegypti Recife population after 48 hours of larval exposure. For L. origanoides, the larvicidal activity ranged from 75% to 100% for Ae. aegypti Liverpool strain, from 61.5% to 100% for Ae. aegypti Rockfeller strain, and from 60.5% to 100% for Ae.aegypti Recife population. The hydro ethanol extract of C. ferrea and L. origanoides presented larvicidal activity against Ae. aegypti.KEY WORDS: Aedes aegypti; hydro ethanol extracts; Caesalpinia ferrea; Lippia sidoides; botanical insecticide; mosquitoes.

Effects of climate change on the spread of zika virus: a public health threat

2018 ◽  
Vol 33 (1) ◽  
pp. 31-42 ◽  
Author(s):  
Hina Asad ◽  
David O. Carpenter
Keyword(s):  
Public Health ◽  
Climate Change ◽  
South America ◽  
Zika Virus ◽  
Human Disease ◽  
Human Population ◽  
Viral Disease ◽  
Health Concerns ◽  
Public Health Threat ◽  
Vector Borne

Abstract Zika is a vector-borne viral disease transmitted to humans primarily by Aedes aegypti mosquitoes. The increased climate instability has contributed to the emergence of infections carried by mosquitoes like dengue, chikungunya and zika. While infection with the zika virus is not new, the recent epidemic of microcephaly in Brazil and other countries in South America resulting from the infection of pregnant women with the zika virus raise a number of serious public health concerns. These include the question of how climate change affects the range of zika vectors, what can we do to shorten the length of mosquito season, how and why the symptoms of zika infection have changed and what can be done to reduce the burden of human disease from this infection? Another important question that needs to be answered is what are the factors that caused the zika virus to leave the non-human primates and/or other mammals and invade the human population?

scholarly journals siRNA Design to Silence the 3′UTR Region of Zika Virus

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
María Perez-Mendez ◽  
Paola Zárate-Segura ◽  
Juan Salas-Benito ◽  
Fernando Bastida-González
Keyword(s):  
Public Health ◽  
Blood Transfusion ◽  
Aedes Aegypti ◽  
Cell Line ◽  
Birth Defects ◽  
Zika Virus ◽  
In Silico ◽  
Small Interfering Rnas ◽  
Medical Problems ◽  
Sirna Design

The disease caused by the Zika virus (ZIKV) has positioned itself as one of the main public health problems in Mexico. One of the main reasons is it causes microcephaly and other birth defects. The transmission of ZIKV is through Aedes aegypti and Ae. albopictus mosquitoes, which are found in a larger space of the national territory. In addition, it can also be transmitted via blood transfusion, sexual relations, and maternal-fetal route. So far, there are no vaccines or specific treatments to deal with this infection. Currently, some new therapeutics such as small interfering RNAs (siRNAs) are able to regulate or suppress transcription in viruses. Therefore, in this project, an in silico siRNA was designed for the 3′UTR region of ZIKV via bioinformatics tools. The designed siRNA was synthesized and transfected into the C6/36 cell line, previously infected with ZIKV in order to assess the ability of the siRNA to inhibit viral replication. The designed siRNA was able to inhibit significantly (p<0.05) ZIKV replication; this siRNA could be considered a potential therapeutic towards the disease that causes ZIKV and the medical problems generated.

scholarly journals Harmonisation of Zika virus research protocols to address key public health concerns

2016 ◽  
Vol 4 (12) ◽  
pp. e911-e912 ◽  
Author(s):  
Maria D Van Kerkhove ◽  
Ludovic Reveiz ◽  
Joao Paulo Souza ◽  
Thomas Jaenisch ◽  
Gail Carson ◽  
...  
Keyword(s):  
Public Health ◽  
Zika Virus ◽  
Health Concerns ◽  
Research Protocols ◽  
Virus Research

scholarly journals GESTÃO DOS PNEUS INSERVÍVEIS E SUA CONTRIBUIÇÃO PARA O PROGRAMA DE PREVENÇÃO À DENGUE, FEBRE CHIKUGUNYA E ZIKA VÍRUS NO MUNICÍPIO DE CHAPECÓ (SC)

2018 ◽  
Vol 7 (1) ◽  
pp. 129-143
Author(s):  
Junir Antônio Lutinski ◽  
Suiane Oliveira De Quadros ◽  
Jessica Tiburski ◽  
Cleia De Fátima Bedim
Keyword(s):  
Public Health ◽  
Health Promotion ◽  
Aedes Aegypti ◽  
Zika Virus ◽  
Health Surveillance ◽  
Chikungunya Fever ◽  
Breeding Sites ◽  
Waste Tires ◽  
Urban Solid Waste ◽  
The Relationship

O potencial dos pneus inservíveis como criadouros para o mosquito Aedes aegypti, vetor da Dengue, febre Chikungunya e Zika vírus, é amplamente conhecido. Este estudo teve como objetivos descrever a gestão dos pneus inservíveis no município de Chapecó e avaliar relação entre o número de pneus destinados à Reciclanip e o número de focos de A. aegypti registrados em pneus. A coleta de dados foi realizada no período de maio a agosto de 2016 e teve como base o período de 2010 a 2015. Dados foram obtidos no sitio eletrônico da DIVE/SC e junto ao setor de Vigilância em Saúde Ambiental do município de Chapecó. A quantidade de pneus inservíveis recebidos pelo ecoponto triplicou no período avaliado. A correlação entre a gestão ambientalmente correta dos pneus inservíveis e o número de focos de A. aegypti foi negativa (r = -0,79) e significativa (p0,05). Os resultados encontrados permitem inferir que a gestão ambientalmente correta dos pneus inservíveis contribui positivamente para a promoção da saúde pública, na prevenção da Dengue, febre Chikungunya e Zika vírus.Palavras-chave: Gestão de resíduos. Logística reserva. Promoção da saúde. Resíduos sólidos urbanos. ABSTRACT: The potential of waste tires as breeding sites for the Aedes aegypti mosquito, Dengue, Chikungunya fever and Zika virus vector, is widely known. The aim of this study was to describe the management of waste tires in the municipality of Chapecó and to evaluate the relationship between the number of tires destined for Reciclanip and the number of A. aegypti outbreaks recorded in tires. Data collection was performed from May to August 2016 and was based on the period from 2010 to 2015. Data were obtained from the DIVE/SC website and from the Environmental Health Surveillance sector of Chapecó municipality. The amount of waste tires received by the ecopoint tripled in the evaluated period. The correlation between the environmentally correct management of the waste tires and the number of A. aegypti outbreaks was negative (r = -0.79) and significant (p 0.05). The results found allow to infer that the environmentally correct management of waste tires contributes positively to the promotion of public health in the prevention of Dengue, Chikungunya fever and Zika virus.Keywords: Waste management. Reserve logistics. Health promotion. Urban solid waste.

scholarly journals Zika virus in Brazil: an overview of public health policies

2020 ◽  
Vol 12 (10) ◽  
pp. e4597
Author(s):  
Heverton Valentim Colaço Da Silva ◽  
Almerinda Agrelli ◽  
Ana Sofia Lima Estevão De Oliveira ◽  
Ronald Rodrigues De Moura ◽  
Sergio Crovella ◽  
...  
Keyword(s):  
Public Health ◽  
Aedes Aegypti ◽  
Zika Virus ◽  
Clinical Symptoms ◽  
The State ◽  
Health Policies ◽  
Breeding Sites ◽  
Public Health Policies ◽  
Mosquito Breeding ◽  
Primary Focus

Objective: The purpose of this review was to discuss the effectiveness of public health policies in controlling Zika virus (ZIKV) in Brazil from 2015 to 2019 with an emphasis in the state of Pernambuco. Literature Review: Zika virus is an arbovirus primarily transmitted to humans by Aedes aegypti mosquitoes. Since 2015, the control of Aedes aegypti proliferation and diffusion has been a global subject of discussion due to its role in ZIKV transmission and the emergence of serious clinical symptoms resulting from this infection. In Brazil, the public policies established to control ZIKV outbreak were mostly based on vector control. Final Considerations: The coping model to manage the transmission vector of ZIKV is not showing to be effective.  Furthermore, until the social factors that favor the development and maintenance of mosquito breeding sites are eradicated, Brazil will continue to be susceptible to new outbreaks of mosquito-driven arboviruses. Here, we discussed the effectiveness of public health policies for the control of ZIKV in Brazil from 2015 to 2019, with a primary focus on the state of Pernambuco (PE).

scholarly journals Larvicidal activity of aqueous extracts of Ilex paraguariensis and Ilex theezans on Aedes aegypti (L.)

2020 ◽  
Vol 42 ◽  
pp. e3
Author(s):  
Ana Carla Knakiewicz ◽  
Junir Antonio Lutinski ◽  
Maria Assunta Busato ◽  
Walter Antônio Roman Junior ◽  
Daniel Albeny Simões
Keyword(s):  
Aedes Aegypti ◽  
Larvicidal Activity ◽  
Zika Virus ◽  
Ilex Paraguariensis ◽  
Mosquito Larvae ◽  
Yerba Mate ◽  
Aqueous Extracts ◽  
Plant Variation ◽  
Chikungunya Fever ◽  
Controlled Conditions

Aedes aegypti is the main vector of Dengue, Yellow Urban Fever, Chikungunya fever and Zika virus fever. The strategies for its control include synthetic products that cause damage to the environment and other organisms. This study evaluated the larvicidal activity of aqueous extracts of leaves and fruits of Ilex paraguariensis and Ilex theezans on Aedes aegypti mosquito larvae. The bioassays were conducted at the Ecological Entomology Laboratory, Unochapecó, under controlled conditions of temperature and photoperiod. The extracts of fresh and dried leaves of I. theezans showed greater larvicidal activity when compared to extracts of fruits of the same plant. Variation in larvicidal activity was also observed during exposure periods. The results suggest the use of extracts of these plants in the control of A. aegypti and the prospection of substances that can be used as an alternative to synthetic products. They point to the possibility of using yerba mate tissues that are not used commercially.

scholarly journals Environmental and cultured cyanobacteria as sources of Aedes aegypti larvicides

2019 ◽  
Vol 24 (3) ◽  
pp. 465-496
Author(s):  
Farja I Ayala ◽  
Laura M Becerra ◽  
Jairo Quintana ◽  
Lina M Bayona ◽  
Freddy A Ramos ◽  
...  
Keyword(s):  
Public Health ◽  
Aedes Aegypti ◽  
Bioactive Compounds ◽  
Larvicidal Activity ◽  
Artemia Salina ◽  
Acetylcholinesterase Inhibition ◽  
Effective Control ◽  
Benthic Cyanobacteria ◽  
Organic Extracts ◽  
Chemical Profiles

In tropical countries, the control of the mosquito Aedes aegypti is a public health priority due to its role as a vector of important viral diseases. Marine cyanobacteria are recognized as abundant sources of bioactive compounds, and they constitute a potential source of insecticides useful for controlling mosquito populations and preventing epidemic outbreaks. We collected 30 benthic cyanobacterial mats in Providencia and Rosario islands (in the Colombian Caribbean) belonging to the genera Phormidium, Symploca, Oscillatoria, Lyngbya, Pseudoanabaena, Leptolyngbya, Moorea, and Dapis. Fractions of organic extracts from the most abundant environmental samples were evaluated in three bioassays, assessing (i) larvicidal activity against A. aegypti, (ii) toxicity against the brine shrimp (Artemia salina) nauplii, and (iii) acetylcholinesterase inhibition. Non-polar fractions exhibited larvicidal activity. The polar fraction from one Dapis pleuosa extract showed larvicidal activity without being toxic against A. salina nauplii. Extracts from Moorea producens exhibited the greatest toxicity against A. aegypti larvae and A. salina nauplii. From 23 cultured cyanobacterial samples, only five grew under laboratory conditions and produced enough biomass to yield organic extracts. Of these, three extracts showed strong larvicidal activity, but only the extract from Phormidium tenue showed reduced toxicity against A. salina nauplii. We detected variation among the chemical profiles and larvicidal activity of cyanobacterial consortia depending on sites and dates of collection. Our findings suggest that despite variation in chemical profiles, extracts of marine benthic cyanobacteria can be further developed as effective control agents against insect vectors, in their larval stages. The culture of marine benthic cyanobacteria needs to be further explored to provide enough biomass leading to the identification of bioactive compounds with public health applications.

scholarly journals Zika virus (ZIKV) disease: past, present and future

2018 ◽  
Vol 8 (6-s) ◽  
pp. 320-327 ◽  
Author(s):  
Sweety Khatri ◽  
Chandni Dhanoriya ◽  
Deepak Kumar Jain
Keyword(s):  
Public Health ◽  
Aedes Aegypti ◽  
Zika Virus ◽  
Mosquito Control ◽  
Rna Virus ◽  
Clinical Manifestations ◽  
Autoimmune Disorder ◽  
Public Health Authority ◽  
Health Crisis ◽  
The World

The mosquito-borne arbovirus Zika virus (positive-stranded RNA virus, ZIKV, Flavivirus, Flaviviridae), has caused an outbreak imposing by its extent and quick spread. This became the focus of a current pandemic and public health crisis all around the world because of the incessant geographic growth of both the virus and its mosquito vectors; it is often misdiagnosed with other disease like yellow fever, west nile, dengue and chikungunya because of same clinical manifestation. After unprecedented huge scale outbreak of ZIKV in Pacific, Micronesian island of Yap in 2007, though ZIKV infections are in general sporadic cases or causing mild self-limiting illness, harsh symptoms have been explained including neurological disorders, autoimmune disorder, fetal anomalies, impaired central nervous system of the fetus, microcephaly in newborns, meningoencephalitis, myelitis and Guillain Barre´Syndrome supposed to be linked with ZIKV. The virus is transmitted mainly by a mosquito Aedes aegypti, whereas, other routes of viral broadcast includes monkey bite, coitus and body fluids such as semen, blood and saliva which needs further corroboration. The relationship between these conditions with ZIKV infection is still not established and is under assessment. Till now there is no vaccine or specific antiviral against ZIKV, therefore the public health authority focuses on preventing infection, mainly in pregnant women and virus transmitted area. WHO and other health officials are working on the expansion of new projects and mosquito control techniques to manage up with infection as there is very fewer literature present on the pathogenesis of the ZIKV to help understand the clinical disease spectrum and target treatments to decrease or stop infection. The future status of ZIKV dispersal to other parts of the world is still unknown. The present review emphasizes various features of ZIKV and its history, epidemiology, transmission, clinical manifestations, progress  and advances in developing effective diagnostics, vaccines and drugs/therapeutics along with accepting suitable avoidance and control strategies to undertake this deadly emerging disease. Keywords: Zika virus, Flavivirus, Aedes aegypti, Pregnancy, Transmission, Microcephaly, Africa

Sign in / Sign up

Export Citation Format

Share Document