scholarly journals Poly(ethylene glycol) modified Mn2+ complexes as contrast agents with a prolonged observation window in rat MRA

RSC Advances ◽  
2017 ◽  
Vol 7 (86) ◽  
pp. 54603-54609 ◽  
Author(s):  
Changqiang Wu ◽  
Li Yang ◽  
Zhuzhong Chen ◽  
Houbing Zhang ◽  
Danyang Li ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Contrast Agents ◽  
Blood Circulation ◽  
Circulation Time ◽  
Poly Ethylene Glycol ◽  
Observation Window ◽  
Prolonged Observation ◽  
Poly Ethylene

PEGylated Mn2+ complexes show higher relaxivity and longer blood circulation time than free Mn2+ complexes.

A Study on PELGE Nanoparticles as Controlled Drug Delivery Systems for Intravenous

2005 ◽  
Vol 288-289 ◽  
pp. 163-166 ◽  
Author(s):  
You Rong Duan ◽  
W.S. Liu ◽  
J. Liu ◽  
Z.R. Zhang
Keyword(s):  
Ethylene Glycol ◽  
Blood Circulation ◽  
Controlled Drug Delivery ◽  
Drug Carriers ◽  
Circulation Time ◽  
Poly Ethylene Glycol ◽  
Systemic Blood ◽  
Model Drug ◽  
Poly Ethylene

The objective of this study was to evaluate the in vivo characteristics of poly (ethylene glycol)-poly (lacticacid-co-glycolicacid)-poly (ethylene- glycol) (PELGE) copolymers as drug carriers. In order to test this circulation time, mitoxantrone (DHAQ) was used as a model drug in this study. DHAQ nanoparticles (DHAQ-NP) were prepared, subsequently the DHAQ-NP were evaluated by measuring the drug concentration in plasma after intravenous administration via the tail vein of mice. The circulation time of the DHAQ-NP were tested. The results showed prolonged mitoxantrone (DHAQ) residence in systemic blood circulation.

CD47 Functionalization of Nanoparticles as a Poly(ethylene glycol) Alternative: A Novel Approach to Improve Drug Delivery

2021 ◽  
Vol 22 ◽  
Author(s):  
Noushin Rezaei Vandchali ◽  
Fatemeh Moadab ◽  
Eskandar Taghizadeh ◽  
Amir Tajbakhsh ◽  
Seyed Mohammad Gheibi-hayat
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Retention Time ◽  
Blood Circulation ◽  
Regulatory Protein ◽  
Reticuloendothelial System ◽  
Poly Ethylene Glycol ◽  
Drug Delivery Vehicles ◽  
Novel Approach ◽  
Poly Ethylene

Abstract: Bio-degradable nanoparticles (NPs) have several utilizations as the drug delivery vehicles due to their acceptable bio-availability, lower toxicity, potency for encapsulation and controlled release. Moreover, interaction of the NPs with the macrophages of reticuloendothelial system (RES) may decrease NPs efficacy for medical purposes. The surface of NPs is conventionally neutralized with the molecules such as poly(ethylene glycol) (PEG), as one of the most widely applied stealth polymers, in order to restrict the NPs clearance through the RES system. In fact, these molecules exhibit resistance to the RES clearance and proteins adsorption. It is unfortunate that modifying the PEG has some shortcomings like problems in the synthesis as well as correlation to the immune reaction. The CD47 receptor has been well known as a ‘don’t-eat-me’ molecule on the self-cells' surface. Therefore, the receptor will inhibit phagocytosis via binding to its ligand that is known as the signal regulatory protein α (SIRP-α). Moreover, the CD47 receptor, as one of the biomimetic substances, or its derivative peptides have been used recently on the surface of nanoparticles to inhibit phagocytosis and increase the NPs retention time in the blood circulation. Therefore, this review study examined the CD47 receptor and its role in the immune system as well as the use of the CD47 receptor in coating NPs to increase their retention time in the blood circulation.

scholarly journals X-Ray Imaging of Poly(Ethylene Glycol) Hydrogels Without Contrast Agents

2010 ◽  
Vol 16 (6) ◽  
pp. 1597-1600 ◽  
Author(s):  
Eric M. Brey ◽  
Alyssa Appel ◽  
Yu-Chieh Chiu ◽  
Zhong Zhong ◽  
Ming-Huei Cheng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Contrast Agents ◽  
Poly Ethylene Glycol ◽  
X Ray ◽  
X Ray Imaging ◽  
Poly Ethylene

scholarly journals The Importance of Poly(ethylene glycol) Alternatives for Overcoming PEG Immunogenicity in Drug Delivery and Bioconjugation

Polymers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 298 ◽  
Author(s):  
Thai Thanh Hoang Thi ◽  
Emily H. Pilkington ◽  
Dai Hai Nguyen ◽  
Jung Seok Lee ◽  
Ki Dong Park ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Blood Circulation ◽  
Drug Efficacy ◽  
Poly Ethylene Glycol ◽  
Life Threatening ◽  
Poly Ethylene ◽  
Interfering Rna ◽  
Accelerated Blood Clearance ◽  
Established Technique

Poly(ethylene glycol) (PEG) is widely used as a gold standard in bioconjugation and nanomedicine to prolong blood circulation time and improve drug efficacy. The conjugation of PEG to proteins, peptides, oligonucleotides (DNA, small interfering RNA (siRNA), microRNA (miRNA)) and nanoparticles is a well-established technique known as PEGylation, with PEGylated products have been using in clinics for the last few decades. However, it is increasingly recognized that treating patients with PEGylated drugs can lead to the formation of antibodies that specifically recognize and bind to PEG (i.e., anti-PEG antibodies). Anti-PEG antibodies are also found in patients who have never been treated with PEGylated drugs but have consumed products containing PEG. Consequently, treating patients who have acquired anti-PEG antibodies with PEGylated drugs results in accelerated blood clearance, low drug efficacy, hypersensitivity, and, in some cases, life-threatening side effects. In this succinct review, we collate recent literature to draw the attention of polymer chemists to the issue of PEG immunogenicity in drug delivery and bioconjugation, thereby highlighting the importance of developing alternative polymers to replace PEG. Several promising yet imperfect alternatives to PEG are also discussed. To achieve asatisfactory alternative, further joint efforts of polymer chemists and scientists in related fields are urgently needed to design, synthesize and evaluate new alternatives to PEG.

Synthesis of poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide) block copolymers with well-defined structures and their influence on in vivo circulation and biodistribution

2014 ◽  
Vol 5 (19) ◽  
pp. 5617-5627 ◽  
Author(s):  
Qingsong Yu ◽  
Chengyan Dong ◽  
Jiajing Zhang ◽  
Jiyun Shi ◽  
Bing Jia ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Circulation Time ◽  
Poly Ethylene Glycol ◽  
Hydroxypropyl Methacrylamide ◽  
Poly Ethylene

PEG-b-PHPMA block copolymers with a precisely controlled composition were synthesized and showed a good biodistribution pattern and long circulation time.

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