Synthesis of poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide) block copolymers with well-defined structures and their influence on in vivo circulation and biodistribution

2014 ◽  
Vol 5 (19) ◽  
pp. 5617-5627 ◽  
Author(s):  
Qingsong Yu ◽  
Chengyan Dong ◽  
Jiajing Zhang ◽  
Jiyun Shi ◽  
Bing Jia ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Circulation Time ◽  
Poly Ethylene Glycol ◽  
Hydroxypropyl Methacrylamide ◽  
Poly Ethylene

PEG-b-PHPMA block copolymers with a precisely controlled composition were synthesized and showed a good biodistribution pattern and long circulation time.

In vivo and in vitro degradation of poly(ether ester) block copolymers based on poly(ethylene glycol) and poly(butylene terephthalate)

Biomaterials ◽  
2004 ◽  
Vol 25 (2) ◽  
pp. 247-258 ◽  
Author(s):  
A.A. Deschamps ◽  
A.A. van Apeldoorn ◽  
H. Hayen ◽  
J.D. de Bruijn ◽  
U. Karst ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
In Vitro Degradation ◽  
Butylene Terephthalate ◽  
Poly Ethylene ◽  
Ether Ester

A Study on PELGE Nanoparticles as Controlled Drug Delivery Systems for Intravenous

2005 ◽  
Vol 288-289 ◽  
pp. 163-166 ◽  
Author(s):  
You Rong Duan ◽  
W.S. Liu ◽  
J. Liu ◽  
Z.R. Zhang
Keyword(s):  
Ethylene Glycol ◽  
Blood Circulation ◽  
Controlled Drug Delivery ◽  
Drug Carriers ◽  
Circulation Time ◽  
Poly Ethylene Glycol ◽  
Systemic Blood ◽  
Model Drug ◽  
Poly Ethylene

The objective of this study was to evaluate the in vivo characteristics of poly (ethylene glycol)-poly (lacticacid-co-glycolicacid)-poly (ethylene- glycol) (PELGE) copolymers as drug carriers. In order to test this circulation time, mitoxantrone (DHAQ) was used as a model drug in this study. DHAQ nanoparticles (DHAQ-NP) were prepared, subsequently the DHAQ-NP were evaluated by measuring the drug concentration in plasma after intravenous administration via the tail vein of mice. The circulation time of the DHAQ-NP were tested. The results showed prolonged mitoxantrone (DHAQ) residence in systemic blood circulation.

In vitro and in vivo complement activation and related anaphylactic effects associated with polyethylenimine and polyethylenimine-graft-poly(ethylene glycol) block copolymers

Biomaterials ◽  
2011 ◽  
Vol 32 (21) ◽  
pp. 4936-4942 ◽  
Author(s):  
Olivia M. Merkel ◽  
Rudolf Urbanics ◽  
Peter Bedőcs ◽  
Zoltán Rozsnyay ◽  
László Rosivall ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Complement Activation ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Insertion of poly(ethylene glycol) derivatized phospholipid into pre-formed liposomes results in prolonged in vivo circulation time

FEBS Letters ◽  
1996 ◽  
Vol 386 (2-3) ◽  
pp. 243-246 ◽  
Author(s):  
Paul S. Uster ◽  
Theresa M. Allen ◽  
Barbra E. Daniel ◽  
Cecilia J. Mendez ◽  
Mary S. Newman ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Circulation Time ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Amphiphilic Copolymers for Long-Acting Injectables: Synthesis, Non-Acylating Performance and In Vivo Degradation

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1438
Author(s):  
Silvio Curia ◽  
Feifei Ng ◽  
Marie-Emérentienne Cagnon ◽  
Victor Nicoulin ◽  
Adolfo Lopez-Noriega
Keyword(s):  
Ethylene Glycol ◽  
Ring Opening ◽  
Gel Chromatography ◽  
Amphiphilic Copolymers ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Long Acting ◽  
In Vivo Degradation

This article presents the evaluation of diblock and triblock poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) amphiphilic copolymers (PEG-PTMCs) as excipients for the formulation of long-acting injectables (LAIs). Copolymers were successfully synthesised through bulk ring-opening polymerisation. The concomitant formation of PTMC homopolymer could not be avoided irrespective of the catalyst amount, but the by-product could easily be removed by gel chromatography. Pure PEG-PTMCs undergo faster erosion in vivo than their corresponding homopolymer. Furthermore, these copolymers show outstanding stability compared to their polyester analogues when formulated with amine-containing reactive drugs, which makes them particularly suitable as LAIs for the sustained release of drugs susceptible to acylation.

scholarly journals Intracellular Trafficking of Polyamidoamine–Poly(ethylene glycol) Block Copolymers in DNA Delivery

2011 ◽  
Vol 22 (8) ◽  
pp. 1519-1525 ◽  
Author(s):  
Daniel K. Bonner ◽  
Cheuk Leung ◽  
Jane Chen-Liang ◽  
Loice Chingozha ◽  
Robert Langer ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Intracellular Trafficking ◽  
Dna Delivery ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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