scholarly journals SPIONs/DOX loaded polymer nanoparticles for MRI detection and efficient cell targeting drug delivery

RSC Advances ◽  
2017 ◽  
Vol 7 (75) ◽  
pp. 47715-47725 ◽  
Author(s):  
Le Shang ◽  
Qiu-yue Wang ◽  
Kang-long Chen ◽  
Jing Qu ◽  
Qing-han Zhou ◽  
...  

Reducible polydopamine coated magnetic nanoparticles (SPIONs@PDA) for both magnetic resonance imaging (MRI) detection and cell targeting drug delivery.

2018 ◽  
pp. 1424-1447
Author(s):  
Irshad Ahmad Wani

Magnetic nanoparticles due to their unique magnetic phenomenon, are gaining immense interest due to the utilization of these properties for a wide variety of applications in various arena especially in biomedical field. This book chapter, therefore, summarizes the synthesis of various types of magnetic nanoparticles using different approaches depending of their ability to generate either single core of multcore magnetic nanoparticles. The various biomedical applications of magnetic nanoparticles like Magnetic Resonance Imaging (MRI), drug delivery etc. along with possible limitations and challenges for their extended applications in medicine are also discussed.


Author(s):  
Irshad Ahmad Wani

Magnetic nanoparticles due to their unique magnetic phenomenon, are gaining immense interest due to the utilization of these properties for a wide variety of applications in various arena especially in biomedical field. This book chapter, therefore, summarizes the synthesis of various types of magnetic nanoparticles using different approaches depending of their ability to generate either single core of multcore magnetic nanoparticles. The various biomedical applications of magnetic nanoparticles like Magnetic Resonance Imaging (MRI), drug delivery etc. along with possible limitations and challenges for their extended applications in medicine are also discussed.


2020 ◽  
Vol 11 (2) ◽  
pp. 8654-8668

Superparamagnetic nanoparticles contain unique magnetic properties that differ from the bulk materials and are able to function at a cellular level due to their size, shape, and surface characteristics. These features make them attractive candidates for drug delivery systems, thermal mediators in hyperthermia, and magnetic resonance imaging (MRI) contrast agents. This review provides an up-to-date overview of the application of iron oxide nanoparticles in cancer diagnosis, drug delivery, treatment, and safety concerns related to these materials are considered, as well. Furthermore, the general principles and challenges of the magnetic behavior of nanoparticles in the field of oncology are also discussed. Firstly, the basic requirements for magnetic nanoparticles for biomedical applications are outlined. The close link between structure, shape, size, and magnetic characterization are described, which is considered essential for non-invasive imaging modality, innovative magnetic-driven nanocarriers, and treatment based on the overheating. In conclusion, investigation of the toxicity profile of novel nanoparticles is provided, as well. In the current review, the attention is focused on the role of magnetic nanoparticles, especially iron oxide nanoparticles in some bioapplications such as magnetic resonance imaging (MRI) contrast agents, targeted drug delivery, and magnetic hyperthermia systems.


2019 ◽  
Vol 5 (4) ◽  
pp. 55 ◽  
Author(s):  
Hosu ◽  
Tertis ◽  
Cristea

During the last few decades, magnetic nanoparticles have been evaluated as promising materials in the field of cancer detection, screening, and treatment. Early diagnosis and screening of cancer may be achieved using magnetic nanoparticles either within the magnetic resonance imaging technique and/or sensing systems. These sensors are designed to selectively detect specific biomarkers, compounds that can be related to the onset or evolution of cancer, during and after the treatment of this widespread disease. Some of the particular properties of magnetic nanoparticles are extensively exploited in cancer therapy as drug delivery agents to selectively target the envisaged location by tailored in vivo manipulation using an external magnetic field. Furthermore, individualized treatment with antineoplastic drugs may be combined with magnetic resonance imaging to achieve an efficient therapy. This review summarizes the studies about the implications of magnetic nanoparticles in cancer diagnosis, treatment and drug delivery as well as prospects for future development and challenges of magnetic nanoparticles in the field of oncology.


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