scholarly journals Micro-solvation of tyrosine-kinase inhibitor AG1478 explored with fluorescence spectroscopy and computational chemistry

RSC Advances ◽  
2017 ◽  
Vol 7 (50) ◽  
pp. 31725-31735 ◽  
Author(s):  
Muhammad Khattab ◽  
Feng Wang ◽  
Andrew H. A. Clayton
Keyword(s):  
Fluorescence Quenching ◽  
Fluorescence Spectroscopy ◽  
Protein Binding ◽  
Tyrosine Kinase Inhibitor ◽  
Computational Chemistry ◽  
Kinase Inhibitor ◽  
Water Molecules ◽  
Probe Drug ◽  
Explicit Water ◽  
Drug Protein Binding

Fluorescence quenching of the anticancer AG1478, by at least three explicit water molecules, can be exploited to probe drug–protein binding interactions.

Tyrosine kinase inhibitor (TKI) treatment outcome of stage IV-C thyroid differentiated cancer (analyzed by lesion evaluation)

2018 ◽  
Author(s):  
Hiroyuki Iwasaki ◽  
Haruhiko Yamazaki ◽  
Nobuyasu Suganuma ◽  
Yuko Sugawara ◽  
Naoki Gotoh ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Kinase Inhibitor ◽  
Stage Iv ◽  
Tki Treatment
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