scholarly journals Regioselective synthesis of dipyrrolopyrazine (DPP) derivatives via metal free and metal catalyzed amination and investigation of their optical and thermal properties

RSC Advances ◽  
2017 ◽  
Vol 7 (29) ◽  
pp. 18120-18131 ◽  
Author(s):  
Puttavva Meti ◽  
Eun-Sil Lee ◽  
Jung-Won Yang ◽  
Young-Dae Gong
Keyword(s):  
Thermal Properties ◽  
Regioselective Synthesis ◽  
Optoelectronic Materials ◽  
Molecular Scaffold ◽  
Metal Free ◽  
Organic Optoelectronic ◽  
Metal Catalyzed

Pyrazine is an important molecular scaffold employed in organic optoelectronic materials.

scholarly journals Recent Advances in the Regioselective Synthesis of Indoles via C–H Activation/Functionalization

Synthesis ◽  
2018 ◽  
Vol 50 (14) ◽  
pp. 2655-2677 ◽  
Author(s):  
Upendra Sharma ◽  
Inder Kumar ◽  
Rakesh Kumar
Keyword(s):  
Natural Products ◽  
Regioselective Synthesis ◽  
Metal Free ◽  
Bioactive Natural Products ◽  
Recent Advances ◽  
Metal Catalyzed ◽  
Indole Synthesis

Indole is an important heterocyclic motif that occurs ubiquitously in bioactive natural products and pharmaceuticals. Immense efforts have been devoted to the synthesis of indoles starting from the Fisher indole synthesis to the recently developed C–H activation/functionalization-based methods. Herein, we have reviewed the progress made on the regioselective synthesis of functionalized indoles, including 2-substituted, 3-substituted and 2,3-disusbstituted indoles, since the year 2010.1 Introduction2 Metal-Catalyzed Synthesis of 2-Substituted Indoles3 Metal-Catalyzed Synthesis of 3-Substituted Indoles4 Metal-Free Synthesis of 3-Substituted Indoles5 Metal-Catalyzed 2,3-Disubstituted Indole Synthesis5.1 Metal-Catalyzed Intramolecular 2,3-Disubstituted Indole Synthesis5.2 Metal-Catalyzed Intermolecular 2,3-Disubstituted Indole Synthesis6 Metal-Free 2,3-Disubstituted Indole Synthesis6.1 N-Protected 2,3-Disubstituted Indole Synthesis6.2 N-Unprotected 2,3-Disubstituted Indole Synthesis7 Applications8 Summary and Outlook

scholarly journals Recent Advances in Transition-Metal-Free (4+3)-Annulations

Synthesis ◽  
2021 ◽  
Author(s):  
Heather Lam ◽  
Mark Lautens ◽  
Xavier Abel-Snape ◽  
Martin F. Köllen
Keyword(s):  
Transition Metal ◽  
Boronic Acid ◽  
Lewis Acids ◽  
Acid Catalysis ◽  
Heterocyclic Carbenes ◽  
Bronsted Acids ◽  
Metal Free ◽  
Previous Review ◽  
Dual Activation ◽  
Metal Catalyzed

Abstract(4+3)-Annulations are incredibly versatile reactions which combine a 4-atom synthon and a 3-atom synthon to form both 7-membered carbocycles as well as heterocycles. We have previously reviewed transition-metal-catalyzed (4+3)-annulations. In this review, we will cover examples involving bases, NHCs, phosphines, Lewis and Brønsted acids as well as some rare examples of boronic acid catalysis and photocatalysis. In analogy to our previous review, we exclude annulations involving cyclic dienes like furan, pyrrole, cyclohexadiene or cyclopentadiene, as Chiu, Harmata, Fernándes and others have recently published reviews encompassing such substrates. We will however discuss the recent additions (2010–2020) to the literature on (4+3)-annulations involving other types of 4-atom-synthons.1 Introduction2 Bases3 Annulations Using N-Heterocyclic Carbenes3.1 N-Heterocyclic Carbenes (NHCs)3.2 N-Heterocyclic Carbenes and Base Dual-Activation4 Phosphines5 Acids5.1 Lewis Acids5.2 Brønsted Acids6 Boronic Acid Catalysis and Photocatalysis7 Conclusion

Iodine-mediated C–N and C–S bond formation: regioselective synthesis of benzo[4,5]imidazo[2,1-b]thiazoles

2017 ◽  
Vol 41 (1) ◽  
pp. 75-80 ◽  
Author(s):  
Sethurajan Ambethkar ◽  
Muthalu Vellimalai ◽  
Vediappen Padmini ◽  
Nattamai Bhuvanesh
Keyword(s):  
Reaction Time ◽  
Intramolecular Cyclization ◽  
Simple Procedure ◽  
Bond Formation ◽  
Molecular Iodine ◽  
Regioselective Synthesis ◽  
Thiazole Derivatives ◽  
Short Reaction Time ◽  
Metal Free

The regioselective synthesis of benzo[4,5]imidazo[2,1-b]thiazole derivatives via amination (C–N) and intramolecular cyclization (C–S) reactions in the presence of molecular iodine has been reported. This method is base and metal free and features inexpensive catalysts, with a simple procedure and a short reaction time.

scholarly journals Oxidizing agents in metal-catalyzed and metal-free C-H functionalization of heteroarenes.

ARKIVOC ◽  
2021 ◽  
Vol 2021 (9) ◽  
Author(s):  
Irina Alexandrovna Utepova ◽  
Oleg Nikolaevich Chupakhin ◽  
Maria Alexandrovna Trestsova ◽  
Alexandra Alexandrovna Musikhina ◽  
Alexandr Alexandrovich Shchepochkin ◽  
...  
Keyword(s):  
Metal Free ◽  
Oxidizing Agents ◽  
Metal Catalyzed

Iodine–NH4OAc mediated regioselective synthesis of 2-aroyl-3-arylimidazo[1,2-a]pyridines from 1,3-diaryl-prop-2-en-1-ones

2018 ◽  
Vol 16 (8) ◽  
pp. 1330-1336 ◽  
Author(s):  
Dilpreet Kour ◽  
Annah Gupta ◽  
Kamal K. Kapoor ◽  
Vivek K. Gupta ◽  
Rajnikant Rajnikant ◽  
...  
Keyword(s):  
Regioselective Synthesis ◽  
Metal Free

An efficient, metal-free regioselective synthesis of 2-aroyl-3-arylimidazo[1,2-a]pyridines from 1,3-diaryl-prop-2-en-1-ones has been developed by their reaction with 2-aminopyridine in the presence of I2/NH4OAc.

Five-Membered Hetarene N-Oxides: Recent Advances in Synthesis and Reactivity

Synthesis ◽  
2021 ◽  
Author(s):  
Leonid Fershtat ◽  
Fedor Teslenko
Keyword(s):  
Transition Metal ◽  
Medicinal Chemistry ◽  
Materials Science ◽  
State Of The Art ◽  
Short Review ◽  
Advanced Materials ◽  
Metal Free ◽  
Recent Advances ◽  
Application Potential ◽  
Metal Catalyzed

Five-membered heterocyclic N-oxides attracted special attention due to their strong application potential in medicinal chemistry and advanced materials science. In this regard, novel methods for their synthesis and functionalization are constantly required. In this short review, recent state-of-the-art achievements in the chemistry of isoxazoline N-oxides, 1,2,3-triazole 1-oxides and 1,2,5-oxadiazole 2-oxides are briefly summarized. Main routes to transition-metal-catalyzed and metal-free functionalization protocols along with mechanistic considerations are outlined. Transformation patterns of the hetarene N-oxide rings as precursors to other nitrogen heterocyclic systems are also presented.

Recent advances in graphitic carbon nitride as catalyst for heterogeneous Fenton-like reaction

2021 ◽  
Author(s):  
Jia Fei ◽  
Xin Peng ◽  
Longbo Jiang ◽  
Xingzhong Yuan ◽  
Xiangyan Chen ◽  
...  
Keyword(s):  
Thermal Properties ◽  
Carbon Nitride ◽  
Graphitic Carbon ◽  
Graphitic Carbon Nitride ◽  
Heterogeneous Fenton ◽  
Metal Free ◽  
Recent Advances ◽  
Stable Chemical ◽  
Structural Regulation

Graphitic carbon nitride (g-C3N4), an appealing metal-free polymer has gained extensive research in heterogeneous Fenton-like reactions owing to its advantages of stable chemical and thermal properties, easy of structural regulation...

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