Iodine–NH4OAc mediated regioselective synthesis of 2-aroyl-3-arylimidazo[1,2-a]pyridines from 1,3-diaryl-prop-2-en-1-ones

2018 ◽  
Vol 16 (8) ◽  
pp. 1330-1336 ◽  
Author(s):  
Dilpreet Kour ◽  
Annah Gupta ◽  
Kamal K. Kapoor ◽  
Vivek K. Gupta ◽  
Rajnikant Rajnikant ◽  
...  
Keyword(s):  
Regioselective Synthesis ◽  
Metal Free

An efficient, metal-free regioselective synthesis of 2-aroyl-3-arylimidazo[1,2-a]pyridines from 1,3-diaryl-prop-2-en-1-ones has been developed by their reaction with 2-aminopyridine in the presence of I2/NH4OAc.

Iodine-mediated C–N and C–S bond formation: regioselective synthesis of benzo[4,5]imidazo[2,1-b]thiazoles

2017 ◽  
Vol 41 (1) ◽  
pp. 75-80 ◽  
Author(s):  
Sethurajan Ambethkar ◽  
Muthalu Vellimalai ◽  
Vediappen Padmini ◽  
Nattamai Bhuvanesh
Keyword(s):  
Reaction Time ◽  
Intramolecular Cyclization ◽  
Simple Procedure ◽  
Bond Formation ◽  
Molecular Iodine ◽  
Regioselective Synthesis ◽  
Thiazole Derivatives ◽  
Short Reaction Time ◽  
Metal Free

The regioselective synthesis of benzo[4,5]imidazo[2,1-b]thiazole derivatives via amination (C–N) and intramolecular cyclization (C–S) reactions in the presence of molecular iodine has been reported. This method is base and metal free and features inexpensive catalysts, with a simple procedure and a short reaction time.

ChemInform Abstract: Regioselective Synthesis of Phenoxathiin Derivatives under Transition-Metal-Free Conditions.

ChemInform ◽  
2013 ◽  
Vol 44 (30) ◽  
pp. no-no
Author(s):  
Fangdong Hu ◽  
Xin Zhao ◽  
Yanqiu Li ◽  
Lei Feng ◽  
Chen Ma
Keyword(s):  
Transition Metal ◽  
Regioselective Synthesis ◽  
Metal Free

A transition metal-free approach towards the regioselective synthesis of β-carboline tethered pyrroles and 2,3-dihydro-1H-pyrroles

2020 ◽  
Vol 44 (28) ◽  
pp. 12370-12383
Author(s):  
Manpreet Singh ◽  
Avijit Kumar Paul ◽  
Virender Singh
Keyword(s):  
Transition Metal ◽  
Regioselective Synthesis ◽  
One Pot ◽  
Sequential Approach ◽  
Metal Free

A transition metal-free one-pot sequential approach has been unfolded for the synthesis of β-carboline tethered pyrroles and 2,3-dihydro-1H-pyrroles by using highly diverse 1-formyl-9H-β-carbolines as a template.

Metal-free Decarboxylative Amination: An Alternative Approach Towards Regioselective Synthesis of β-CarbolineN-fused Imidazoles

2017 ◽  
Vol 359 (7) ◽  
pp. 1213-1226 ◽  
Author(s):  
Dharmender Singh ◽  
Vipin Kumar ◽  
Nisha Devi ◽  
Chandi C. Malakar ◽  
Ravi Shankar ◽  
...  
Keyword(s):  
Regioselective Synthesis ◽  
Metal Free ◽  
Alternative Approach

DABCO Promoted Regioselective Synthesis of New Diversely Functionalized 3-Hydroxy-2-Oxindole Scaffolds

2014 ◽  
Vol 67 (5) ◽  
pp. 768 ◽  
Author(s):  
Pramod B. Thakur ◽  
Jagdeesh B. Nanubolu ◽  
Harshadas M. Meshram
Keyword(s):  
Catalytic Amount ◽  
Regioselective Synthesis ◽  
Reaction Conditions ◽  
Metal Free ◽  
Structural Framework

An efficient and highly regioselective γ-addition of β-keto sulfones on isatins has been achieved in the presence of a catalytic amount of 1,4-diazabicyclo[2.2.2]octane (DABCO) to afford a γ-(3-hydroxy-2-oxindole)-β-keto sulfone structural framework. The scope of the method is tested by screening a series of isatin electrophiles as well as β-keto sulfones. The described method was found to be very handy and provides straightforward access for the diversely functionalized 3-β-keto sulfone substituted-3-hydroxy-2-oxindole structural scaffolds in very good yields from readily available starting materials under metal-free reaction conditions.

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