scholarly journals Three novel transition metal complexes of 6-methyl-2-oxo-quinoline-3-carbaldehyde thiosemicarbazone: synthesis, crystal structure, cytotoxicity, and mechanism of action

RSC Advances ◽  
2017 ◽  
Vol 7 (29) ◽  
pp. 17923-17933 ◽  
Author(s):  
Bi-Qun Zou ◽  
Xing Lu ◽  
Qi-Pin Qin ◽  
Yu-Xia Bai ◽  
Ye Zhang ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Transition Metal ◽  
Metal Complexes ◽  
Mitochondrial Dysfunction ◽  
Tumor Cells ◽  
Transition Metal Complexes ◽  
Mechanism Of Action ◽  
Normal Cells

Complex 1 was more selective for MGC80-3 tumor cells versus normal cells (HL-7702). Importantly, 1 triggered MGC80-3 cells apoptosis via a mitochondrial dysfunction pathway.

scholarly journals Ru(II)-Dppz Derivatives and Their Interactions with DNA: Thirty Years and Counting

2021 ◽  
Vol 11 (7) ◽  
pp. 3038
Author(s):  
Maria Letizia Di Pietro ◽  
Giuseppina La Ganga ◽  
Francesco Nastasi ◽  
Fausto Puntoriero
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Small Molecules ◽  
Transition Metal Complexes ◽  
Mechanism Of Action ◽  
Spectroscopic Techniques ◽  
Biological Applications ◽  
Ancillary Ligands ◽  
Structural Modifications ◽  
Over Time

Transition metal complexes with dppz-type ligands (dppz = dipyrido[3,2-a:2′,3′-c]phenazine) are extensively studied and attract a considerable amount of attention, becoming, from the very beginning and increasingly over time, a powerful tool for investigating the structure of the DNA helix. In particular, [Ru(bpy)2(dppz)]2+ and [Ru(phen)2(dppz)]2+ and their derivatives were extensively investigated as DNA light-switches. The purpose of this mini-review, which is not and could not be exhaustive, was to first introduce DNA and its importance at a biological level and research in the field of small molecules that are capable of interacting with it, in all its forms. A brief overview is given of the results obtained on the Ru-dppz complexes that bind to DNA. The mechanism of the light-switch active in this type of species is also briefly introduced along with its effects on structural modifications on both the dppz ligand and the ancillary ligands. Finally, a brief mention is made of biological applications and the developments obtained due to new spectroscopic techniques, both for understanding the mechanism of action and for cellular imaging applications.

Transition metal complexes with monodeprotonated isoorotic and 2-thioisoorotic acids: Crystal structure, spectral and magnetic study, and antimicrobial activity

1993 ◽  
Vol 51 (3) ◽  
pp. 613-632 ◽  
Author(s):  
F. Hueso-Ureña ◽  
M.N. Moreno-Carretero ◽  
M.A. Romero-Molina ◽  
J.M. Salas-Peregrin ◽  
M.P. Sanchez-Sanchez ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Antimicrobial Activity ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Magnetic Study

Synthesis, crystal structure, hydrogen bonding and spectroscopy of transition-metal complexes with the ligand (N,N′-bis(2-pyridylmethyl)-1,3-propanediamine)

Polyhedron ◽  
2009 ◽  
Vol 28 (14) ◽  
pp. 2813-2820 ◽  
Author(s):  
Aminou Mohamadou ◽  
Gerard A. van Albada ◽  
Ilpo Mutikainen ◽  
Urho Turpeinen ◽  
Jérôme Marrot ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Hydrogen Bonding ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes
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