scholarly journals Recent developments in chemical reactivity of N,N-dimethylenamino ketones as synthons for various heterocycles

RSC Advances ◽  
2017 ◽  
Vol 7 (24) ◽  
pp. 14562-14610 ◽  
Author(s):  
Hatem M. Gaber ◽  
Mark C. Bagley ◽  
Zeinab A. Muhammad ◽  
Sobhi M. Gomha
Keyword(s):  
Heterocyclic Compounds ◽  
Chemical Reactivity ◽  
Recent Developments

This review demonstrates the high number of synthetic applications of enaminones in the preparation of acyclic, carbocyclic, heterocyclic and fused heterocyclic compounds.

Recent advances of thiazole hybrids in biological applications

2019 ◽  
Vol 11 (15) ◽  
pp. 1979-1998 ◽  
Author(s):  
Mehmet Gümüş ◽  
Mehmet Yakan ◽  
İrfan Koca
Keyword(s):  
Biological Activity ◽  
Heterocyclic Compounds ◽  
Chemical Reactivity ◽  
Biological Properties ◽  
The Other ◽  
Hybrid Structures ◽  
Thiazole Ring ◽  
Biological Applications ◽  
Recent Advances ◽  
Recent Developments

Thiazoles have attracted much synthetic interest due to their wide variety of biological properties and are important members of heterocyclic compounds. In recent years, studies on the synthesis of thiazole compounds have been increasing because of the properties of this core. In particular, the hybrid structures in which the thiazole ring and the other nuclei are linked have gained popularity. Hybrid structures are formed by the combination of different groups of chemical reactivity and biological activity characteristics. In this review, we highlight recent developments related to hybrid structures containing a thiazole core, recently developed as anticancer, antibacterial, anti-inflammatory, analgesic, anti-tubercular, antialzheimer and antidiabetic compounds.

scholarly journals Recent advances in the electrochemical construction of heterocycles

2014 ◽  
Vol 10 ◽  
pp. 2858-2873 ◽  
Author(s):  
Robert Francke
Keyword(s):  
Heterocyclic Compounds ◽  
Elevated Temperatures ◽  
Ring Formation ◽  
Environmentally Benign ◽  
Heterocyclic Chemistry ◽  
Ambient Conditions ◽  
Recent Developments ◽  
Strong Acids ◽  
Selection Of ◽  
Made In

Due to the fact that the major portion of pharmaceuticals and agrochemicals contains heterocyclic units and since the overall number of commercially used heterocyclic compounds is steadily growing, heterocyclic chemistry remains in the focus of the synthetic community. Enormous efforts have been made in the last decades in order to render the production of such compounds more selective and efficient. However, most of the conventional methods for the construction of heterocyclic cores still involve the use of strong acids or bases, the operation at elevated temperatures and/or the use of expensive catalysts and reagents. In this regard, electrosynthesis can provide a milder and more environmentally benign alternative. In fact, numerous examples for the electrochemical construction of heterocycles have been reported in recent years. These cases demonstrate that ring formation can be achieved efficiently under ambient conditions without the use of additional reagents. In order to account for the recent developments in this field, a selection of representative reactions is presented and discussed in this review.

scholarly journals Recent Developments on 1,3-Dipolar Cycloaddition Reactions by Catalysis in Green Solvents

Catalysts ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 65 ◽  
Author(s):  
Loredana Maiuolo ◽  
Vincenzo Algieri ◽  
Fabrizio Olivito ◽  
Antonio De Nino
Keyword(s):  
Ionic Liquids ◽  
Heterocyclic Compounds ◽  
Deep Eutectic Solvents ◽  
Dipolar Cycloaddition ◽  
Cycloaddition Reactions ◽  
Important Class ◽  
Green Solvents ◽  
Dipolar Cycloadditions ◽  
Recent Developments ◽  
Selection Of

The use of eco-compatible synthetic procedures in organic reactions and, in particular, in 1,3-dipolar cycloaddition reactions, has recently received a great deal of attention and considerable progress has been achieved in this area in the last years. This review summarizes the approaches currently employed to synthesize heterocyclic compounds by catalyzed 1,3-dipolar cycloadditions in green solvents in the last six years. Our choice to do a selection of the literature from 2014 to 2019 was made considering the absence of a recent review about this period, to our knowledge. Several examples to construct heterocycles by 1,3-dipolar cycloadditions will be discussed in this work subdivided in function of the most important class of non-conventional and green solvents, i.e., ionic liquids (ILs), deep eutectic solvents (DES), and water.

scholarly journals Anticancer activity of benzoxazole derivative (2015 onwards): a review

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Tanay Ghoshal ◽  
Tarun M. Patel
Keyword(s):  
Anticancer Activity ◽  
Heterocyclic Compounds ◽  
Drug Research ◽  
World Health ◽  
Therapeutic Area ◽  
Design And Synthesis ◽  
The World ◽  
Recent Developments ◽  
Health Organization ◽  
Made In

Abstract Background According to the report published recently by the World Health Organization, the number of cancer cases in the world will increase to 22 million by 2030. So the anticancer drug research and development is taking place in the direction where the new entities are developed which are low in toxicity and are with improved activity. Benzoxazole and its derivative represent a very important class of heterocyclic compounds, which have a diverse therapeutic area. Recently, many active compounds synthesized are very effective; natural products isolated with benzoxazole moiety have also shown to be potent towards cancer. Main text In the last few years, many research groups have designed and developed many novel compounds with benzoxazole as their backbone and checked their anticancer activity. In the review article, the recent developments (mostly after 2015) made in the direction of design and synthesis of new scaffolds with very potent anticancer activity are briefly described. The effect of various heterocycles attached to the benzoxazole and their effect on the anticancer activity are thoroughly studied and recorded in the review. Conclusion These compiled data in the article will surely update the scientific community with the recent development in this area and will provide direction for further research in this area.

ChemInform Abstract: Some Recent Developments on the Synthesis, Chemical Reactivity, and Theoretical Studies of Tetroxanes

ChemInform ◽  
2013 ◽  
Vol 44 (37) ◽  
pp. no-no
Author(s):  
Nelly L. Jorge ◽  
Alfonso Hernandez-Laguna ◽  
Eduardo A. Castro
Keyword(s):  
Chemical Reactivity ◽  
Theoretical Studies ◽  
Recent Developments

Recent Developments in the Synthesis and Antimicrobial Activity of Indole and its Derivatives

2019 ◽  
Vol 16 (1) ◽  
pp. 17-37 ◽  
Author(s):  
Jaskirat Kaur ◽  
Divya Utreja ◽  
Ekta ◽  
Nisha Jain ◽  
Shivali Sharma
Keyword(s):  
Antimicrobial Activity ◽  
Microbial Activity ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Antimicrobial Properties ◽  
Biological Properties ◽  
Indole Derivatives ◽  
Antimicrobial Drugs ◽  
Wide Range ◽  
Recent Developments

Background:Heterocyclic compounds containing nitrogen have been known to possess a very important role in the field of medicinal chemistry. Indole and its derivatives displayed a wide range of biological properties such as anti-inflammatory, analgesic, anti-microbial, anti-convulsant, antidepressant, anti-diabetic, antihelmintic and anti-allergic activities etc. The diverse biological activities exhibited by compounds containing indole moiety has provided the impetus to explore its anti-microbial activity in order to save the valuable life of patients. </P><P> Objective: The review focuses on the advances in the synthesis of indole derivatives and antimicrobial properties exhibited by them.Conclusion:A great deal of work has been done in order to synthesize indole derivatives and to evaluate antimicrobial potential, as indicated by the review. The information provided in this article may be helpful for the researchers for the development of efficient antimicrobial drugs.

Invited Review. Combinatorial Synthesis: A Heterocyclic Chemist's Perspective

1998 ◽  
Vol 51 (10) ◽  
pp. 875 ◽  
Author(s):  
Wendy A. Loughlin
Keyword(s):  
Heterocyclic Compounds ◽  
Combinatorial Synthesis ◽  
Solution Phase ◽  
Recent Developments

An overview of the combinatorial synthesis of heterocyclic compounds is presented. Recent developments and innovations in the solid and solution phase combinatorial synthesis of heterocyclic compounds are discussed.

Some Recent Developments on the Synthesis, Chemical Reactivity, and Theoretical Studies of Tetroxanes

2013 ◽  
Vol 3 (1) ◽  
pp. 48-73
Author(s):  
Nelly L. Jorge ◽  
Alfonso Hernández-Laguna ◽  
Eduardo A. Castro
Keyword(s):  
Physical Chemistry ◽  
Triplet State ◽  
Critical Points ◽  
Ground State ◽  
Chemical Reactivity ◽  
Singlet Ground State ◽  
Theoretical Studies ◽  
Reaction Paths ◽  
Recent Developments

The authors present a review on some recent developments on the synthesis, chemical reactivity and theoretical studies of Tetroxanes analysing their main physical chemistry properties. The authors examine the critical points of the PES of different conformers, and reaction paths at singlet ground state and triplet state of the tetroxane, leader member of the cyclic diperoxide compound family.

Recent Developments Using Phosphorlts-Containing Diol as a Reactive Combustion Modifier for Rigid Polyltrethane Foams-Part Iii

1984 ◽  
Vol 2 (6) ◽  
pp. 439-453 ◽  
Author(s):  
F.T. Lee ◽  
J. Green ◽  
R.D. Gibilisco
Keyword(s):  
Chemical Reactivity ◽  
Cost Effective ◽  
Class Ii ◽  
Class I ◽  
High Chemical ◽  
Phosphorus Containing ◽  
Recent Developments ◽  
High Chemical Reactivity

FR-D, a new phosphorus-containing diol has, previously, been demonstrated to be an effective combustion modifier in producing pour-in-place rigid urethane foams meeting ASTM E-84 Class I and Class II requirements. Continued developmental efforts led to optimized Class I and Class II foams which contain significantly less amount of combustion modifiers and are thus more cost effective than those reported earlier. FR-D is also suitable for spray foam applications because of its high chemical reactivity and high hydroxy number (#OH = 460). In this paper, recently developed FR-D based Class I and Class II pour as well as spray formulations along with their processing characteristics, E-84 data and foam physicals are discussed.

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