Phenylboronic acid-incorporated elastin-like polypeptide nanoparticle drug delivery systems

2017 ◽  
Vol 8 (13) ◽  
pp. 2105-2114 ◽  
Author(s):  
Weizhi Chen ◽  
Shilu Ji ◽  
Xiaoping Qian ◽  
Yajun Zhang ◽  
Cheng Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Therapeutic Effect ◽  
Drug Delivery Systems ◽  
Phenylboronic Acid ◽  
Aqueous Solubility ◽  
Delivery Systems ◽  
Hydrophobic Drugs ◽  
Specific Accumulation ◽  
Nanoparticle Drug Delivery

Packaging hydrophobic drugs into nanoparticles can improve their aqueous solubility, tumor-specific accumulation and therapeutic effect.

scholarly journals A REVIEW ON CURRENT STATUS OF SELF-EMULSIFYING DRUG DELIVERY SYSTEMS

2019 ◽  
Vol 3 (7) ◽  
Author(s):  
R. Nagaraju ◽  
Damineni Saritha ◽  
P. Subhash Chandra Bose ◽  
G. Ravi ◽  
Valluru Ravi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Aqueous Solubility ◽  
Delivery Systems ◽  
Current Status ◽  
Hydrophobic Drugs ◽  
Related Information ◽  
Main Challenge ◽  
Drug Compounds ◽  
Gentle Agitation

The modern drug delivery system of hydrophobic drugs presents a main challenge because of the poor aqueous solubility of such compounds. Self emulsifying drug delivery systems (SEDDS) are usually used to enhance the bioavailability of hydrophobic drugs. SEDDS can be administered orally in soft or hard gelatin capsules and form fine relatively stable oil in water (o/w) emulsions upon aqueous dilution due to the gentle agitation of the gastrointestinal fluids. From time to time so many workers have claimed different rational applications of Self-emulsifying formulation for increcing bioavailability and site-specific targeting of highly lipophilic drugs. Significant improvement in the oral bioavailability of these drug compounds has been demonstrated for each case. The fact that almost 40% of the new drug compounds are hydrophobic in nature implies that studies with SEDDS will continue, and more drug compounds formulated as SEDDS will reach the pharmaceutical market in the future. The present article gives an overview of the Composition, mechanism, advantages, disadvantages, characterization, recent advancements, patents related information of SEEDS and commercial products approved for oral transmucosal administration.

Self-microemulsion Technology for Water-insoluble Drug Delivery

2019 ◽  
Vol 15 (6) ◽  
pp. 576-588 ◽  
Author(s):  
Beibei Yan ◽  
Yu Gu ◽  
Juan Zhao ◽  
Yangyang Liu ◽  
Lulu Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Aqueous Solubility ◽  
Delivery Systems ◽  
Poorly Soluble Drugs ◽  
New Chemical Entities ◽  
Poorly Soluble ◽  
Water Insoluble Drug ◽  
Semi Solid ◽  
Solidification Technology

: According to the drug discovery, approximately 40% of the new chemical entities show poor bioavailability due to their low aqueous solubility. In order to increase the solubility of the drugs, self-micro emulsifying drug delivery systems (SMEDDS) are considered as an ideal technology for enhancing the permeability of poorly soluble drugs in GI membranes. The SMEDDS are also generally used to enhance the oral bioavailability of the hydrophobic drugs. At present, most of the self-microemulsion drugs are liquid dosage forms, which could cause some disadvantages, such as the low bioavailability of the traditional liquid SMEDDS. Therefore, solid self-micro emulsifying drug delivery systems (S-SMEDDS) have emerged widely in recent years, which were prepared by solidifying a semi-solid or liquid self-emulsifying (SE) ingredient into a powder in order to improve stability, treatment and patient compliance. The article gives a comprehensive introduction of the study of SMEDDS which could effectively tackle the problem of the water-insoluble drug, especially the development of solidification technology of SMEDDS. Finally, the present challenges and the prospects in this field were also discussed.

Nanoparticle Drug Delivery Systems: Recent Patents and Applications in Nanomedicine

2014 ◽  
Vol 3 (2) ◽  
pp. 105-118 ◽  
Author(s):  
Pedro Martins ◽  
Daniela Rosa ◽  
Alexandra Fernandes ◽  
Pedro V. Baptista
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Nanoparticle Drug Delivery

A Review on Formulation and Development of Solid Self-Nano Emulsifying Drug Delivery Systems

2021 ◽  
Vol 14 (4) ◽  
pp. 5519-5228
Author(s):  
Sunitha M Reddy ◽  
Sravani Baskarla
Keyword(s):  
Drug Delivery ◽  
Dissolution Rate ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Water Solubility ◽  
Drug Loading ◽  
Aqueous Solubility ◽  
Delivery Systems ◽  
Particle Size Reduction

This article describes current strategies to enhance aqueous solubility and dissolution rate of poor soluble drugs. Most drugs in the market are lipophilic with low or poor water solubility. There are various methods to enhance solubility: co-solvency, particle size reduction, salt formation and Self Nanoemulsifying drug delivery systems, SEDDS is a novel approach to enhance solubility, dissolution rate and bioavailability of drugs. The study involves formulation and evaluation of solid self-Nano emulsifying drug delivery system (S-SNEDDS) to enhance aqueous solubility and dissolution rate. Oral route is the most convenient route for non-invasive administration. S-SNEDDS has more advantages when compared to the liquid self-emulsifying drug delivery system. Excipients were selected depends upon the drug compatibility oils, surfactants and co surfactants were selected to formulate Liquid SNEDDS these formulated liquid self-nano emulsifying drug delivery system converted into solid by the help of porous carriers, Melted binder or with the help of drying process. Conversion process of liquid to solid involves various techniques; they are spray drying; freeze drying and fluid bed coating technique; extrusion, melting granulation technique. Liquid SNEDDS has a high ability to improve dissolution and solubility of drugs but it also has disadvantages like incompatibility, decreased drug loading, shorter shelf life, ease of manufacturing and ability to deliver peptides that are prone to enzymatic hydrolysis.  

scholarly journals Micro and nanoparticle drug delivery systems for preventing allotransplant rejection

2015 ◽  
Vol 160 (1) ◽  
pp. 24-35 ◽  
Author(s):  
James D. Fisher ◽  
Abhinav P. Acharya ◽  
Steven R. Little
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Nanoparticle Drug Delivery

Polymeric Drug Delivery Systems for Encapsulating Hydrophobic Drugs

2013 ◽  
pp. 151-197 ◽  
Author(s):  
Naveed Ahmed ◽  
C.E. Mora-Huertas ◽  
Chiraz Jaafar-Maalej ◽  
Hatem Fessi ◽  
Abdelhamid Elaissari
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Hydrophobic Drugs ◽  
Polymeric Drug Delivery ◽  
Polymeric Drug ◽  
Polymeric Drug Delivery Systems

Self-Emulsifying Drug Delivery Systems: A Strategy to Improve the Bioavailability of Hydrophobic Drugs

2021 ◽  
pp. 129-164
Author(s):  
Ankita Banerjee ◽  
Rajesh Kumar ◽  
Monica Gulati ◽  
Sachin Kumar Singh ◽  
Kamal Dua ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Hydrophobic Drugs

scholarly journals Rational design of drug delivery systems for potential programmable drug release and improved therapeutic effect

2019 ◽  
Vol 3 (6) ◽  
pp. 1159-1167 ◽  
Author(s):  
Yuxun Ding ◽  
Jinjian Liu ◽  
Xue Li ◽  
Linlin Xu ◽  
Chang Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Therapeutic Effect ◽  
Drug Delivery Systems ◽  
Rational Design ◽  
Delivery Systems ◽  
Dual Responsive ◽  
Ph Reduction

pH-Reduction dual responsive nanocarriers (DRNs) achieve programmable release of CA4 and CDDP in cancer therapy.

scholarly journals Phenylboronic acid-decorated polymeric nanomaterials for advanced bio-application

2019 ◽  
Vol 8 (1) ◽  
pp. 548-561
Author(s):  
Tianyu Lan ◽  
Qianqian Guo
Keyword(s):  
Drug Delivery ◽  
Sialic Acid ◽  
Drug Delivery Systems ◽  
Phenylboronic Acid ◽  
Delivery Systems ◽  
Therapeutic Applications ◽  
The Past ◽  
Recent Advances

Abstract The paradigm of using phenylboronic acid-decorated polymeric nanomaterials for advanced bio-application has been well established over the past decade. Phenylboronic acid and its derivatives are known to form reversible complexes with polyols, including sugar, diol and diphenol. This unique chemistry of phenylboronic acid has given many chances to be exploited for diagnostic and therapeutic applications. This review highlights the recent advances in fabrication of phenylboronic acid-decorated polymeric nanomaterials, especially focus on the interactions with glucose and sialic acid. Applications of these phenylboronic acid-decorated nanomaterials in drug delivery systems and biosensors are discussed.

Sign in / Sign up

Export Citation Format

Share Document