Synthesis of 4-substituted pyrazole-3,5-diamines via Suzuki–Miyaura coupling and iron-catalyzed reduction

2017 ◽  
Vol 15 (48) ◽  
pp. 10200-10211 ◽  
Author(s):  
Monika Tomanová ◽  
Lukáš Jedinák ◽  
Jan Košař ◽  
Lubomír Kvapil ◽  
Pavel Hradil ◽  
...  
Keyword(s):  
Efficient Synthesis ◽  
Substituted 1 ◽  
Styryl Group

A general and efficient synthesis of 4-substituted-1H-pyrazole-3,5-diamines was developed to access derivatives with an aryl, heteroaryl, or styryl group, which are otherwise relatively difficult to prepare.

Efficient synthesis of 2-substituted 1-phenylchromen[3,4-d]imidazol-4(1H)-ones with possible anti-inflammatory activity

ARKIVOC ◽  
2020 ◽  
Vol 2020 (6) ◽  
pp. 126-138
Author(s):  
Thomas D. Balalas ◽  
Asterios K. Theologis ◽  
Konstantina Mazaraki ◽  
Catherine Gabriel ◽  
Eleni Pontiki ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Efficient Synthesis ◽  
Anti Inflammatory ◽  
Substituted 1

ChemInform Abstract: New and Highly Efficient Synthesis of 3-Substituted 1-Hydroxybenz[g]isoquinoline-5,10-diones.

ChemInform ◽  
2009 ◽  
Vol 40 (23) ◽  
Author(s):  
Jan Jacobs ◽  
Sven Claessens ◽  
Blaise Mavinga Mbala ◽  
Kris Huygen ◽  
Norbert De Kimpe
Keyword(s):  
Efficient Synthesis ◽  
Highly Efficient ◽  
Substituted 1

The Efficient Synthesis of N4-Substituted 1-Methylcytosines

1991 ◽  
Vol 21 (14) ◽  
pp. 1489-1500 ◽  
Author(s):  
Lech Celewicz ◽  
Krzysztof Ciszewski ◽  
Krzysztof Golankiewicz
Keyword(s):  
Efficient Synthesis ◽  
Substituted 1

ChemInform Abstract: Simple and Efficient Synthesis of 5-Substituted 1-H-Tetrazoles Using Metal-Modified Clay Catalysts.

ChemInform ◽  
2011 ◽  
Vol 42 (27) ◽  
pp. no-no
Author(s):  
Alireza Najafi Chermahini ◽  
Abbas Teimouri ◽  
Ali Moaddeli
Keyword(s):  
Efficient Synthesis ◽  
Modified Clay ◽  
Substituted 1 ◽  
Clay Catalysts

ChemInform Abstract: The Efficient Synthesis of N4-Substituted 1-Methylcytosines.

ChemInform ◽  
2010 ◽  
Vol 23 (9) ◽  
pp. no-no
Author(s):  
L. CELEWICZ ◽  
K. CISZEWSKI ◽  
K. GOLANKIEWICZ
Keyword(s):  
Efficient Synthesis ◽  
Substituted 1

Expedient Entry to 1-Aminoadamantane Derivatives via Aza-Prins Cyclization of 7-Methylenebicyclo[3.3.1]nonan-3-one Oximes

Synthesis ◽  
2018 ◽  
Vol 50 (09) ◽  
pp. 1820-1826 ◽  
Author(s):  
Yoshiharu Iwabuchi ◽  
Tetsuya Kuga ◽  
Yusuke Sasano ◽  
Masaki Tomizawa ◽  
Masatoshi Shibuya
Keyword(s):  
Efficient Synthesis ◽  
Prins Cyclization ◽  
Grob Fragmentation ◽  
Substituted 1

An efficient synthesis of 1-aminoadamantane (amantadine) derivatives is described. This synthesis features acid-promoted aza-Prins cyclization of 7-methylenebicyclo[3.3.1]nonan-3-one oximes, which are readily prepared from 1,3-adamantanediol via a Grob fragmentation and the subsequent oximation, to give various 3-substituted 1-(alkoxyamino)adamantanes. After the reduction of alkoxyamines, not only 3-substituted 1-aminoadamantanes, but also chiral 2,5-disubstituted derivatives were obtained in good yields.

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