Sugar hydrazide imides: a new family of glycosidase inhibitors

2017 ◽  
Vol 15 (41) ◽  
pp. 8709-8712 ◽  
Author(s):  
Emil Lindbäck ◽  
Óscar Lopéz ◽  
Ådne Tobiesen ◽  
José G. Fernández-Bolaños ◽  
Magne O. Sydnes
Keyword(s):  
Glycosidase Inhibitors ◽  
New Family ◽  
New Type ◽  
Glycosidase Inhibitor ◽  
Micromolar Range

We present a new type of glycosidase inhibitor including a unique hydrazide imide moiety, which displays inhibition in the low micromolar range.

Synthesis of Selenium Analogues of the Naturally Occurring Glycosidase Inhibitor Salacinol and Their Evaluation as Glycosidase Inhibitors†

2002 ◽  
Vol 124 (28) ◽  
pp. 8245-8250 ◽  
Author(s):  
Blair D. Johnston ◽  
Ahmad Ghavami ◽  
Morten T. Jensen ◽  
Birte Svensson ◽  
B. Mario Pinto
Keyword(s):  
Glycosidase Inhibitors ◽  
Naturally Occurring ◽  
Glycosidase Inhibitor

scholarly journals The Metallophore Staphylopine Enables Staphylococcus aureus To Compete with the Host for Zinc and Overcome Nutritional Immunity

mBio ◽  
2017 ◽  
Vol 8 (5) ◽  
Author(s):  
Kyle P. Grim ◽  
Brian San Francisco ◽  
Jana N. Radin ◽  
Erin B. Brazel ◽  
Jessica L. Kelliher ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Host Defense ◽  
Iron Acquisition ◽  
Essential Metals ◽  
Immune Effector ◽  
Essential Metal ◽  
Zinc Availability ◽  
Nutritional Immunity ◽  
New Family ◽  
New Type

ABSTRACT During infection, the host sequesters essential nutrients, such as zinc, to combat invading microbes. Despite the ability of the immune effector protein calprotectin to bind zinc with subpicomolar affinity, Staphylococcus aureus is able to successfully compete with the host for zinc. However, the zinc importers expressed by S. aureus remain unknown. Our investigations have revealed that S. aureus possesses two importers, AdcABC and CntABCDF, which are induced in response to zinc limitation. While AdcABC is similar to known zinc importers in other bacteria, CntABCDF has not previously been associated with zinc acquisition. Concurrent loss of the two systems severely impairs the ability of S. aureus to obtain zinc and grow in zinc-limited environments. Further investigations revealed that the Cnt system is responsible for the ability of S. aureus to compete with calprotectin for zinc in culture and contributes to acquisition of zinc during infection. The cnt locus also enables S. aureus to produce the broad-spectrum metallophore staphylopine. Similarly to the Cnt transporter, loss of staphylopine severely impairs the ability of S. aureus to resist host-imposed zinc starvation, both in culture and during infection. Further investigations revealed that together staphylopine and the Cnt importer function analogously to siderophore-based iron acquisition systems in order to facilitate zinc acquisition by S. aureus. Analogous systems are found in a broad range of Gram-positive and Gram-negative bacterial pathogens, suggesting that this new type of zinc importer broadly contributes to the ability of bacteria to cause infection. IMPORTANCE A critical host defense against infection is the restriction of zinc availability. Despite the subpicomolar affinity of the immune effector calprotectin for zinc, Staphylococcus aureus can successfully compete for this essential metal. Here, we describe two zinc importers, AdcABC and CntABCDF, possessed by S. aureus, the latter of which has not previously been associated with zinc acquisition. The ability of S. aureus to compete with the host for zinc is dependent on CntABCDF and the metallophore staphylopine, both in culture and during infection. These results expand the mechanisms utilized by bacteria to obtain zinc, beyond Adc-like systems, and demonstrate that pathogens utilize strategies similar to siderophore-based iron acquisition to obtain other essential metals during infection. The staphylopine synthesis machinery is present in a diverse collection of bacteria, suggesting that this new family of zinc importers broadly contributes to the ability of numerous pathogens to cause infection. IMPORTANCE A critical host defense against infection is the restriction of zinc availability. Despite the subpicomolar affinity of the immune effector calprotectin for zinc, Staphylococcus aureus can successfully compete for this essential metal. Here, we describe two zinc importers, AdcABC and CntABCDF, possessed by S. aureus, the latter of which has not previously been associated with zinc acquisition. The ability of S. aureus to compete with the host for zinc is dependent on CntABCDF and the metallophore staphylopine, both in culture and during infection. These results expand the mechanisms utilized by bacteria to obtain zinc, beyond Adc-like systems, and demonstrate that pathogens utilize strategies similar to siderophore-based iron acquisition to obtain other essential metals during infection. The staphylopine synthesis machinery is present in a diverse collection of bacteria, suggesting that this new family of zinc importers broadly contributes to the ability of numerous pathogens to cause infection.

N-alkyl-3-decarboxy-3-hydroxymethylsiastatin B, a New Family of Glycosidase Inhibitors ofgem-diamine 1-n-iminosugars

2001 ◽  
Vol 15 (6) ◽  
pp. 371-375 ◽  
Author(s):  
Ken-Ichiro Kondo ◽  
Hayamitsu Adachi ◽  
Yoshio Nishimura ◽  
Tomio Takeuchi
Keyword(s):  
Glycosidase Inhibitors ◽  
New Family

ChemInform Abstract: A New Family of Five-Carbon Iminoalditols which are Potent Glycosidase Inhibitors.

ChemInform ◽  
2010 ◽  
Vol 22 (18) ◽  
pp. no-no
Author(s):  
R. C. BERNOTAS ◽  
G. PAPANDREOU ◽  
J. URBACH ◽  
B. GANEM
Keyword(s):  
Glycosidase Inhibitors ◽  
New Family

scholarly journals Calabozoidea, A New Suborder of Stygobiont Isopoda, Discovered in Venezuela

1983 ◽  
Vol 53 (1) ◽  
pp. 165-177 ◽  
Author(s):  
Sylvia E.N. van Lieshout
Keyword(s):  
Type Species ◽  
New Genus ◽  
New Family ◽  
Body Segmentation ◽  
New Type

A new type of stygobiont Isopoda has been collected from wells in the “Ilanos” of Venezuela, near Calabozo, and in the hyporheal of a river in the Aragua State. On account of its body segmentation, and structure of uropods and pleopods, it must be considered as representing a new suborder. A diagnosis of the new suborder, new family and new genus, and a description of the type-species, are provided. Finally, a morphologic comparison with some of the already known suborders is made.

scholarly journals Synthesis and Spectral Study of a New Family of 2,5-Diaryltriazoles Having Restricted Rotation of the 5-Aryl Substituent

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 480 ◽  
Author(s):  
Biligma Tsyrenova ◽  
Valentine Nenajdenko
Keyword(s):  
Heterocyclic System ◽  
Photophysical Properties ◽  
System Structure ◽  
Quantum Yields ◽  
Aryl Substituent ◽  
Light Emitting ◽  
New Family ◽  
Aryl Fragment ◽  
New Type ◽  
Condensed Heterocycles

Efficient synthesis of 2,5-diaryl substituted 4-azido-1,2,3-triazoles by the reaction of sodium azide with dichlorosubstituted diazadienes was demonstrated. The optical properties of the prepared azidotriazoles were studied to reveal a luminescence maximum in the 360–420 nm region. To improve the luminescence quantum yields a family of 4-azido-1,2,3-triazoles bearing ortho-propargyloxy substituents in the 5 position was prepared. Subsequent intramolecular thermal cyclization permits to construct additional triazole fragment and obtain unique benzoxazocine derivatives condensed with two triazole rings. This new family of condensed heterocycles has a flattened heterocyclic system structure to provide more conjugation of the 5-aryl fragment with the triazole core. As a result, a new type of UV/“blue light-emitting” materials with better photophysical properties was obtained.

scholarly journals Fluorous Iminoalditols: A New Family of Glycosidase Inhibitors and Pharmacological Chaperones

ChemBioChem ◽  
2010 ◽  
Vol 11 (14) ◽  
pp. 2026-2033 ◽  
Author(s):  
Georg Schitter ◽  
Andreas J. Steiner ◽  
Gerit Pototschnig ◽  
Elisabeth Scheucher ◽  
Martin Thonhofer ◽  
...  
Keyword(s):  
Glycosidase Inhibitors ◽  
Pharmacological Chaperones ◽  
New Family
Sign in / Sign up

Export Citation Format

Share Document