gem-Diamine 1-N-Iminosugars, a New Family of Glycosidase Inhibitors: Synthesis and Biological Activity

ChemInform ◽  
2006 ◽  
Vol 37 (18) ◽  
Author(s):  
Yoshio Nishimura
Keyword(s):  
Biological Activity ◽  
Glycosidase Inhibitors ◽  
New Family

Flexible Synthesis and Biological Activity of Uronic Acid-Typegem-Diamine 1-N-Iminosugars:  A New Family of Glycosidase Inhibitors

2000 ◽  
Vol 65 (1) ◽  
pp. 2-11 ◽  
Author(s):  
Yoshio Nishimura ◽  
Eiki Shitara ◽  
Hayamitsu Adachi ◽  
Minako Toyoshima ◽  
Motowo Nakajima ◽  
...  
Keyword(s):  
Biological Activity ◽  
Uronic Acid ◽  
Glycosidase Inhibitors ◽  
New Family

From Bench to Bedside

2011 ◽  
pp. 118-124
Author(s):  
Yong Shen
Keyword(s):  
Biological Activity ◽  
Early Detection ◽  
Tau Protein ◽  
Gamma Secretase ◽  
Focus Attention ◽  
Amyloid Peptides ◽  
New Family ◽  
Amyloid Deposits ◽  
Key Enzyme ◽  
Proteolytic Activities

Alzheimer’s disease (AD) is a constantly progressive and highly complex neurodegenerative disease, and there are many ways to molecularly characterize the various stages. Morphologically, AD patients are characterized by neurofibrillar abnormalities associated with pathological hyperphosphorylation of tau protein, and deposits of ß– amyloid peptides (Aß). There is an overwhelming amount of information to support the hypothesis that generation, formation, and ß-amyloid deposits play key mechanistic roles in the early development of AD. It is known that the cause of early-onset familial AD (FAD) is due to mutations in three genes which cause an increase in the production of the toxic peptide, Aß42. The molecules that cause the proteolytic activities of beta and gamma secretase, two proteases that free the Aß-peptide by endoproteolyzing APP, have recently been discovered. Homologous to BACE1, BACE2 was also a recent discovery (Lin et al, 2000; Vassar et al, 1999; Yan et al, 1999), and together these two enzymes make up a new family of transmembrane aspartic proteases. The key enzyme, BACE1, initiates the formation of Aß, represents a candidate biomarker, as well as a drug target for AD, exhibit all the functional properties of ß–secretase. This chapter will review the biology of BACE1 and focus attention to BACE1 as a candidate biomarker for the early detection, prediction, and biological activity in AD.

scholarly journals Sphingofungins A,B,C, and d; a new family of antifungal agents. I. Fermentation, isolation, and biological activity.

1992 ◽  
Vol 45 (6) ◽  
pp. 861-867 ◽  
Author(s):  
FRANK VANMIDDLESWORTH ◽  
ROBERT A. GIACOBBE ◽  
MARIA LOPEZ ◽  
GEORGE GARRITY ◽  
JUDITH A. BLAND ◽  
...  
Keyword(s):  
Biological Activity ◽  
Antifungal Agents ◽  
New Family

ChemInform Abstract: Preparation and Biological Activity of Manno- and Galacto-Validamines, New 5a-Carba-glycosylamines as α-Glycosidase Inhibitors.

ChemInform ◽  
2010 ◽  
Vol 28 (39) ◽  
pp. no-no
Author(s):  
Y. KAMEDA ◽  
K. KAWASHIMA ◽  
M. TAKEUCHI ◽  
K. IKEDA ◽  
N. ASANO ◽  
...  
Keyword(s):  
Biological Activity ◽  
Glycosidase Inhibitors

Preparation and biological activity of manno- and galacto-validamines, new 5a-carba-glycosylamines as α-glycosidase inhibitors

1997 ◽  
Vol 300 (3) ◽  
pp. 259-264 ◽  
Author(s):  
Yukihiko Kameda ◽  
Kanae Kawashima ◽  
Masayoshi Takeuchi ◽  
Kyoko Ikeda ◽  
Naoki Asano ◽  
...  
Keyword(s):  
Biological Activity ◽  
Glycosidase Inhibitors
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