Synthesis of 3-acylindoles by oxidative rearrangement of 2-aminochalcones using a hypervalent iodine reagent and cyclization sequence

2017 ◽  
Vol 15 (32) ◽  
pp. 6702-6705 ◽  
Author(s):  
Akira Nakamura ◽  
Satoshi Tanaka ◽  
Akira Imamiya ◽  
Reo Takane ◽  
Chiaki Ohta ◽  
...  
Keyword(s):  
Hypervalent Iodine ◽  
One Pot ◽  
Oxidative Rearrangement

An efficient one-pot 3-acylindole synthesis by oxidative rearrangement of 2-aminochalcones and sequential cyclization has been developed.

Hypervalent-Iodine Mediated One-Pot Synthesis of Isoxazolines and Isoxazoles bearing Difluoromethyl Phosphonate Moiety

2021 ◽  
Author(s):  
Romana Pajkert ◽  
Henryk Koroniak ◽  
Pawel Kafarski ◽  
Gerd Volker Roeschenthaler
Keyword(s):  
Nitrile Oxide ◽  
Dipolar Cycloaddition ◽  
Hypervalent Iodine ◽  
One Pot ◽  
One Pot Synthesis

A one-pot, regioselective 1,3-dipolar cycloaddition of in situ generated (diethoxyphosphoryl)difluoromethyl nitrile oxide toward selected alkenes and alkynes is reported. This protocol enables facile access to 3,5-disubstituted isoxazolines and isoxazoles bearing...

One-Pot Protocol for Synthesis of α-Organosulfonyloxy Ketones from Secondary Alcohols Using Hypervalent Iodine(V)–Mediated Oxidations

2009 ◽  
Vol 39 (17) ◽  
pp. 3101-3110 ◽  
Author(s):  
Swapnil S. Deshmukh ◽  
Sameerana N. Huddar ◽  
Krishnacharya G. Akamanchi
Keyword(s):  
Hypervalent Iodine ◽  
Secondary Alcohols ◽  
One Pot

Hypervalent Iodine Mediated One-Pot C-H Functionalization at 2α- or 3α-Position of Indole Derivatives

Heterocycles ◽  
2014 ◽  
Vol 89 (9) ◽  
pp. 2105 ◽  
Author(s):  
Kazuhiro Higuchi ◽  
Tomomi Kawasaki ◽  
Masato Inaba ◽  
Asuka Naganuma ◽  
Takako Ishizaki ◽  
...  
Keyword(s):  
Hypervalent Iodine ◽  
Indole Derivatives ◽  
One Pot

Stereoselective Oxidative Rearrangement of Disubstituted Unactivated Alkenes Using Hypervalent Iodine(III) Reagent

2020 ◽  
Vol 85 (15) ◽  
pp. 10175-10181
Author(s):  
Chandra Bhan Pandey ◽  
Tazeen Azaz ◽  
Ram Subhawan Verma ◽  
Monika Mishra ◽  
Jawahar L. Jat ◽  
...  
Keyword(s):  
Hypervalent Iodine ◽  
Oxidative Rearrangement

Novel One-Pot Preparation of 5-Methoxylated Indoline and Indole Derivatives Using a Hypervalent Iodine(III) Reagent

Heterocycles ◽  
1999 ◽  
Vol 51 (8) ◽  
pp. 1785 ◽  
Author(s):  
Yasuyuki Kita ◽  
Hirofumi Tohma ◽  
Hiroaki Watanabe ◽  
Shinobu Takizawa ◽  
Tomohiro Maegawa
Keyword(s):  
Hypervalent Iodine ◽  
Indole Derivatives ◽  
One Pot

scholarly journals Straightforward Strategies for the Preparation of NH-Sulfox­imines: A Serendipitous Story

Synlett ◽  
2017 ◽  
Vol 28 (19) ◽  
pp. 2525-2538 ◽  
Author(s):  
James Bull ◽  
Renzo Luisi ◽  
Leonardo Degennaro
Keyword(s):  
Transition Metal ◽  
Physicochemical Properties ◽  
Direct Synthesis ◽  
Transition Metal Catalysts ◽  
Hypervalent Iodine ◽  
Reaction Conditions ◽  
One Pot ◽  
Metal Free ◽  
Recent Developments ◽  
New Procedures

Sulfoximines are emerging as valuable new isosteres for use in medicinal chemistry, with the potential to modulate physicochemical properties. Recent developments in synthetic strategies have made the unprotected ‘free’ NH-sulfoximine group more readily available, facilitating further study. This account reviews approaches to NH-sulfoximines, with a focus on our contribution to the field. Starting from the development of catalytic strategies involving transition metals, more sustainable metal-free processes have been discovered. In particular, the use of hypervalent iodine reagents to mediate NH-transfer to sulfoxides is described, along with an assessment of the substrate scope. Furthermore, a one-pot strategy to convert sulfides directly into NH-sulfoximines is discussed, with N- and O-transfer occurring under the reaction conditions. Mechanistic evidence for the new procedures is included as well as relevant synthetic applications that further exemplify the potential of these approaches.1 Introduction2 Strategies to Form NH-Sulfoximines Involving Transition-Metal Catalysts3 Metal-Free Strategies to Prepare NH-Sulfoximines4 Mechanistic Evidence for the Direct Synthesis of NH-Sulfoximines from Sulfoxides and Sulfides5 Further Applications6 Conclusion

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