A multicomponent macrocyclization strategy to natural product-like cyclic lipopeptides: synthesis and anticancer evaluation of surfactin and mycosubtilin analogues

2017 ◽  
Vol 15 (17) ◽  
pp. 3628-3637 ◽  
Author(s):  
Micjel C. Morejón ◽  
Annegret Laub ◽  
Goran N. Kaluđerović ◽  
Alfredo R. Puentes ◽  
Ali N. Hmedat ◽  
...  
Keyword(s):  
Natural Product ◽  
Multicomponent Reactions ◽  
Cyclic Lipopeptides ◽  
One Step

Two birds in one shot: oligopeptides can be cyclized and lipidated in one step with multicomponent reactions.

scholarly journals Cyclic Lipopeptides with Herbicidal and Insecticidal Activities Produced by Bacillus clausii DTM1

2015 ◽  
Vol 10 (12) ◽  
pp. 1934578X1501001 ◽  
Author(s):  
Da-Le Guo ◽  
Bo Wan ◽  
Shi-Ji Xiao ◽  
Sarah Allen ◽  
Yu-Cheng Gu ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Natural Product ◽  
Fermentation Broth ◽  
Cyclic Lipopeptides ◽  
Bacillus Clausii ◽  
Cyclic Lipopeptide ◽  
Lipopeptide Biosurfactants ◽  
First Time ◽  
Insecticidal Activities

Seven cyclic lipopeptide biosurfactants (1–7) were isolated for the first time from the fermentation broth of endophytic Bacillus clausii DTM1 and were identified as anteisoC13[Val7] surfactin-(L-Glu)-O-methyl-ester (1), anteisoC12[Val7] surfactin (2), anteisoC15[Val7] surfactin (3), isoC14[Leu7] surfactin (4), anteisoC12[Leu7] surfactin (5), nC13[Leu7] surfactin (6), and anteisoC14[Leu7] surfactin-(L-Glu)-O-methyl-ester (7); 1 has not been isolated before as a natural product from any source. Plate-based herbicide and insecticide bioassays showed that all compounds exhibited interesting insecticidal and herbicidal activities.

Natural Product Inspired meta/para’-Biaryl Ether Lactam Macrocycles by Double Ugi Multicomponent Reactions

Heterocycles ◽  
2007 ◽  
Vol 73 (1) ◽  
pp. 863 ◽  
Author(s):  
Ludger A. Wessjohann ◽  
Bernhard Westermann ◽  
Dirk Michalik ◽  
Angela Schaks ◽  
Oliver Kreye ◽  
...  
Keyword(s):  
Natural Product ◽  
Multicomponent Reactions ◽  
Biaryl Ether

TiCl 4 ‐Et 3 N‐mediated one‐step synthesis of γ‐alkylidenebutenolides from ketones: Application to natural product synthesis

2020 ◽  
Vol 57 (4) ◽  
pp. 2056-2062
Author(s):  
Xingyi Li ◽  
Yanhong Wang ◽  
Kai Fu ◽  
Zhiyong Hu ◽  
Zhichun Li ◽  
...  
Keyword(s):  
Natural Product ◽  
Natural Product Synthesis ◽  
One Step

scholarly journals Naturally Inspired Pyrimidines Analogues for Alzheimer’s Disease

2020 ◽  
Vol 19 (2) ◽  
pp. 136-151
Author(s):  
Shivani Singh ◽  
Meenakshi Dhanawat ◽  
Sumeet Gupta ◽  
Deepak Kumar ◽  
Saloni Kakkar ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Multicomponent Reactions ◽  
Neurodegenerative Disorder ◽  
The Body ◽  
New Drugs ◽  
Atom Economy ◽  
Step Process ◽  
One Step ◽  
Made In

: Alzheimer’s disease (AD) is a multifarious and developing neurodegenerative disorder. The treatment of AD is still a challenge and availability of drug therapy on the basis of symptoms is not up to the mark. In the context of existence, which is getting worse for the human brain, it is necessary to take care of all critical measures. The disease is caused due to multidirectional pathology of the body, which demands the multi-target-directed ligand (MTDL) approach. This gives hope for new drugs for AD, summarized here in with the pyrimidine based natural product inspired molecule as a lead. The review is sufficient in providing a list of chemical ingredients of the plant to cure AD and screen them against various potential targets of AD. The synthesis of a highly functionalized scaffold in one step in a single pot without isolating the intermediate is a challenging task. In few examples, we have highlighted the importance of this kind of reaction, generally known as multi-component reaction. Multi-component is a widely accepted technique by the drug discovery people due to its high atom economy. It reduces multi-step process to a one-step process, therefore the compounds library can be made in minimum time and cost. This review has highlighted the importance of multicomponent reactions by giving the example of active scaffolds of pyrimidine/fused pyrimidines. This would bring importance to the fast as well as smart synthesis of bio-relevant molecules.

scholarly journals Ultrasound-accelerated arylthiomethylation of indole via multicomponent reaction in water catalyzed by acetic acid

2017 ◽  
Vol 1 (T1) ◽  
pp. 80-85
Author(s):  
Thi Thi Xuan Luu ◽  
Vinh Quang Pham
Keyword(s):  
Acetic Acid ◽  
Multicomponent Reactions ◽  
Main Product ◽  
Step Process ◽  
Magnetic Stirring ◽  
One Step ◽  
Molecular Complexity ◽  
Activation Conditions ◽  
Reaction In Water ◽  
Moderate Yield

Multicomponent reactions (MCRs) play an important role to create the molecular complexity in a one-step process. Based on the mechanism and process of Mannich-type reactions in the synthesis of Grammin, arylthiomethylation reactions of indole were performed by using three components: indole, p-thiocresol and a solution of formaldehyde (36%) under two activation conditions, e.g. magnetic stirring and ultrasonic irradiation. The main product, 3-(p-tolylthiomethyl)-1H-indole, was obtained in a moderate yield (54%) under short irradiation (40 minutes) by probe sonicator.

In Vitro Packaging Mediated One-Step Targeted Cloning of Natural Product Pathway

2019 ◽  
Vol 8 (9) ◽  
pp. 1991-1997 ◽  
Author(s):  
Weixin Tao ◽  
Li Chen ◽  
Chunhua Zhao ◽  
Jing Wu ◽  
Dazhong Yan ◽  
...  
Keyword(s):  
Natural Product ◽  
One Step
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