Two-photon graphene quantum dot modified Gd2O3 nanocomposites as a dual-mode MRI contrast agent and cell labelling agent

Nanoscale ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 5642-5649 ◽  
Author(s):  
F. H. Wang ◽  
K. Bae ◽  
Z. W. Huang ◽  
J. M. Xue
Keyword(s):  
Quantum Dot ◽  
Contrast Agent ◽  
Mri Contrast Agent ◽  
Cell Labelling ◽  
Mri Imaging ◽  
Dual Mode ◽  
Mri Contrast ◽  
Graphene Quantum Dot ◽  
Two Photon ◽  
Dual Functional

Dual-functional Gd2O3/GQD nanocomposites for both photoluminescence imaging and MRI imaging.

scholarly journals Biocompatibility of Bacterial Magnetosomes as MRI Contrast Agent: A Long-Term In Vivo Follow-Up Study

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1235
Author(s):  
Xiaohui Nan ◽  
Wenjia Lai ◽  
Dan Li ◽  
Jiesheng Tian ◽  
Zhiyuan Hu ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Magnetic Domain ◽  
Bilayer Membrane ◽  
The Body ◽  
Mri Contrast Agent ◽  
Mri Imaging ◽  
Mri Contrast

Derived from magnetotactic bacteria (MTB), magnetosomes consist of magnetite crystals enclosed within a lipid bilayer membrane and are known to possess advantages over artificially synthesized nanoparticles because of the narrow size distribution, uniform morphology, high purity and crystallinity, single magnetic domain, good biocompatibility, and easy surface modification. These unique properties have increasingly attracted researchers to apply bacterial magnetosomes (BMs) in the fields of biology and medicine as MRI imaging contrast agents. Due to the concern of biosafety, a long-term follow-up of the distribution and clearance of BMs after entering the body is necessary. In this study, we tracked changes of BMs in major organs of mice up to 135 days after intravenous injection using a combination of several techniques. We not only confirmed the liver as the well-known targeted organs of BMs, but also found that BMs accumulated in the spleen. Besides, two major elimination paths, as well as the approximate length of time for BMs to be cleared from the mice, were revealed. Together, the results not only confirm that BMs have high biocompatibility, but also provide a long-term in-vivo assessment which may further help to forward the clinical applications of BMs as an MRI contrast agent.

Modular design of nanobody–drug conjugates for targeted-delivery of platinum anticancer drugs with an MRI contrast agent

2019 ◽  
Vol 55 (35) ◽  
pp. 5175-5178 ◽  
Author(s):  
Hai Huang ◽  
Tiantian Wu ◽  
Hongdong Shi ◽  
Yun Wu ◽  
Hongyi Yang ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Anticancer Drugs ◽  
Targeted Delivery ◽  
Modular Design ◽  
Drug Distribution ◽  
Mri Contrast Agent ◽  
Mri Imaging ◽  
Mri Contrast ◽  
Drug Conjugates ◽  
Platinum Anticancer Drugs

A multifunctional nanobody–drug conjugate was designed for the targeted-delivery of the Pt(iv) prodrug. The drug distribution can be observed by MRI imaging.

An albumin-based gold nanocomposites as potential dual mode CT/MRI contrast agent

2018 ◽  
Vol 20 (2) ◽  
Author(s):  
Wenjing Zhao ◽  
Lina Chen ◽  
Zhiming Wang ◽  
Yuankui Huang ◽  
Nengqin Jia
Keyword(s):  
Contrast Agent ◽  
Mri Contrast Agent ◽  
Dual Mode ◽  
Mri Contrast ◽  
Gold Nanocomposites

A facile synthetic approach to a biodegradable polydisulfide MRI contrast agent

2014 ◽  
Vol 2 (32) ◽  
pp. 5295-5301 ◽  
Author(s):  
Weiren Cheng ◽  
Reshmi Rajendran ◽  
Wei Ren ◽  
Liuqun Gu ◽  
Yong Zhang ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Side Effects ◽  
Contrast Agent ◽  
Self Assembly ◽  
Mri Contrast Agent ◽  
Synthetic Approach ◽  
Mri Imaging ◽  
Mri Contrast ◽  
Low Cytotoxicity

A biodegradable novel polydisulfide MRI contrast agent forming self-assembly in aqueous solution with a low cytotoxicity and a higherr1is promising for producing better MRI imaging with fewer side effects.

An Ultrahigh‐Field‐Tailored T 1 – T 2 Dual‐Mode MRI Contrast Agent for High‐Performance Vascular Imaging

2020 ◽  
pp. 2004917
Author(s):  
Jin Wang ◽  
Yinhang Jia ◽  
Qiyue Wang ◽  
Zeyu Liang ◽  
Guangxu Han ◽  
...  
Keyword(s):  
Contrast Agent ◽  
High Performance ◽  
Vascular Imaging ◽  
Mri Contrast Agent ◽  
Dual Mode ◽  
Mri Contrast ◽  
Ultrahigh Field

Characterization of Fe3O4/SiO2/Gd2O(CO3)2 core/shell/shell nanoparticles as T1 and T2 dual mode MRI contrast agent

Talanta ◽  
2015 ◽  
Vol 131 ◽  
pp. 661-665 ◽  
Author(s):  
Meicheng Yang ◽  
Lipeng Gao ◽  
Kai Liu ◽  
Chunhua Luo ◽  
Yiting Wang ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Mri Contrast Agent ◽  
Core Shell ◽  
Dual Mode ◽  
Shell Nanoparticles ◽  
Mri Contrast ◽  
T1 And T2

scholarly journals Evaluation of non-targeting, C- or N-pH (low) insertion peptide modified superparamagnetic iron oxide nanoclusters for selective MRI of liver tumors and their potential toxicity in cirrhosis

RSC Advances ◽  
2019 ◽  
Vol 9 (25) ◽  
pp. 14051-14059
Author(s):  
Abdulrahman Ahmed Mahmood ◽  
Jianqi Zhang ◽  
Rufang Liao ◽  
Xiwei Pan ◽  
Dan Xu ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Liver Cancer ◽  
Contrast Agent ◽  
Cancer Diagnosis ◽  
Liver Tumors ◽  
Superparamagnetic Iron Oxide ◽  
Mri Contrast Agent ◽  
Potential Toxicity ◽  
Mri Contrast ◽  
Specific Enhancement

The acid-responsive pHLIP modified SPION as an MRI contrast agent for liver cancer diagnosis requires the validation of both the tumor-specific enhancement and a safe profile in cirrhosis.

Gd2O3 nanoparticles as a positive MRI contrast agent for cell uptake

2010 ◽  
Author(s):  
N. Riyahi-Alam ◽  
J. Behrouzkia ◽  
S. Haghgoo ◽  
A Seifalian ◽  
R Zohdi Aghdam. ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Mri Contrast Agent ◽  
Cell Uptake ◽  
Mri Contrast ◽  
Gd2o3 Nanoparticles
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